Search Results - "Murphy, Gregory J."

PPAR-γ agonists: therapeutic role in diabetes, inflammation and cancer by Murphy, Gregory J, Holder, Julie C

“…The recent development of a novel class of insulin-sensitizing drugs, the thiazolidinediones (TZDs), represents a significant advance in antidiabetic therapy…”
Get full text

Skeletal Muscle of Stroke-Prone Spontaneously Hypertensive Rats Exhibits Reduced Insulin-Stimulated Glucose Transport and Elevated Levels of Caveolin and Flotillin by JAMES, Declan J, CAIRNS, Fiona, SALT, Ian P, MURPHY, Gregory J, DOMINICZAK, Anna F, CONNELL, John M. C, GOULD, Gwyn W

“…Skeletal Muscle of Stroke-Prone Spontaneously Hypertensive Rats Exhibits Reduced Insulin-Stimulated Glucose Transport and Elevated Levels of Caveolin and…”
Get full text

Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3β on a muscle-specific promoter by Pearce, Nigel J., Arch, Jonathan R.S., Clapham, John C., Coghlan, Matthew P., Corcoran, Stacey L., Lister, Carolyn A., Llano, Andrea, Moore, Gary B., Murphy, Gregory J., Smith, Stephen A., Taylor, Colleen M., Yates, John W., Morrison, Alastair D., Harper, Alexander J., Roxbee-Cox, Lynne, Abuin, Alejandro, Wargent, Ed, Holder, Julie C.

“…Glycogen synthase kinase-3 (GSK-3) protein levels and activity are elevated in skeletal muscle in type 2 diabetes, and inversely correlated with both glycogen…”
Get full text

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription by Coghlan, Matthew P, Culbert, Ainsley A, Cross, Darren AE, Corcoran, Stacey L, Yates, John W, Pearce, Nigel J, Rausch, Oliver L, Murphy, Gregory J, Carter, Paul S, Roxbee Cox, Lynne, Mills, David, Brown, Murray J, Haigh, David, Ward, Robert W, Smith, David G, Murray, Kenneth J, Reith, Alastair D, Holder, Julie C

“…Background: Glycogen synthase kinase-3 (GSK-3) is a serine/threonine protein kinase, the activity of which is inhibited by a variety of extracellular stimuli…”
Get full text

Activation of two signal-transduction systems in hepatocytes by glucagon by Wakelam, Michael J. O, Murphy, Gregory J, Hruby, Victor J, Houslay, Miles D

“…The ability of glucagon to stimulate glycogen breakdown in liver played a key part in the classic identification of cyclic AMP and hormonally stimulated…”
Get full text

Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases by Jowsey, I R, Thomson, A M, Flanagan, J U, Murdock, P R, Moore, G B, Meyer, D J, Murphy, G J, Smith, S A, Hayes, J D

“…GSH-dependent prostaglandin D(2) synthase (PGDS) enzymes represent the only vertebrate members of class Sigma glutathione S-transferases (GSTs) identified to…”
Get full text

Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma by Young, P W, Buckle, D R, Cantello, B C, Chapman, H, Clapham, J C, Coyle, P J, Haigh, D, Hindley, R M, Holder, J C, Kallender, H, Latter, A J, Lawrie, K W, Mossakowska, D, Murphy, G J, Roxbee Cox, L, Smith, S A

“…A radioiodinated ligand, [125I]SB-236636 [(S)-(-)3-[4-[2-[N-(2-benzoxazolyl)-N-methylamino]ethoxy]3-[125I]i odo phenyl]2-ethoxy propanoic acid], which is…”
Get more information

Evidence-Based Adequacy Model for School Funding: Success Rates in Illinois Schools that Meet Targets by Murphy, Gregory J

“…This quantitative study explores the 2010 recommendation of the Educational Funding Advisory Board to consider the Evidence-Based Adequacy model of school…”
Get full text

Prostaglandin D2 synthase enzymes and PPARγ are co-expressed in mouse 3T3-L1 adipocytes and human tissues by Jowsey, Ian R., Murdock, Paul R., Moore, Gary B.T., Murphy, Gregory J., Smith, Stephen A., Hayes, John D.

Get full text

Prostaglandin D 2 synthase enzymes and PPARγ are co-expressed in mouse 3T3-L1 adipocytes and human tissues by Jowsey, Ian R., Murdock, Paul R., Moore, Gary B.T., Murphy, Gregory J., Smith, Stephen A., Hayes, John D.

“…Peroxisome proliferator-activated receptor γ (PPARγ) is a critical regulator of adipocyte differentiation. Whilst 15-deoxy-Δ 12,14-prostaglandin J 2 (15-d-PGJ…”
Get full text

v- and t-SNARE protein expression in models of insulin resistance: normalization of glycemia by rosiglitazone treatment corrects overexpression of cellubrevin, vesicle-associated membrane protein-2, and syntaxin 4 in skeletal muscle of Zucker diabetic fatty rats by Maier, V H, Melvin, D R, Lister, C A, Chapman, H, Gould, G W, Murphy, G J

“…v- and t-SNARE protein expression in models of insulin resistance: normalization of glycemia by rosiglitazone treatment corrects overexpression of cellubrevin,…”
Get full text

Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter by Pearce, Nigel J, Arch, Jonathan R S, Clapham, John C, Coghlan, Matthew P, Corcoran, Stacey L, Lister, Carolyn A, Llano, Andrea, Moore, Gary B, Murphy, Gregory J, Smith, Stephen A, Taylor, Colleen M, Yates, John W, Morrison, Alastair D, Harper, Alexander J, Roxbee-Cox, Lynne, Abuin, Alejandro, Wargent, Ed, Holder, Julie C

“…Glycogen synthase kinase-3 (GSK-3) protein levels and activity are elevated in skeletal muscle in type 2 diabetes, and inversely correlated with both glycogen…”
Get full text

Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases by JOWSEY, Ian R., THOMSON, Anne M., FLANAGAN, Jack U., MURDOCK, Paul R., MOORE, Gary B. T., MEYER, David J., MURPHY, Gregory J., SMITH, Stephen A., HAYES, John D.

“…GSH-dependent prostaglandin D2 synthase (PGDS) enzymes represent the only vertebrate members of class Sigma glutathione S-transferases (GSTs) identified to…”
Get full text

Agonist potency at the cloned human beta-3 adrenoceptor depends on receptor expression level and nature of assay by Wilson, S, Chambers, J K, Park, J E, Ladurner, A, Cronk, D W, Chapman, C G, Kallender, H, Browne, M J, Murphy, G J, Young, P W

“…The cloned human beta-3 adrenoceptor was expressed in Chinese hamster ovary cells at three different levels (130, 400 and 3000 fmol/mg). The potency and…”
Get more information

Prostaglandin D2 synthase enzymes and PPARgamma are co-expressed in mouse 3T3-L1 adipocytes and human tissues by Jowsey, Ian R, Murdock, Paul R, Moore, Gary B T, Murphy, Gregory J, Smith, Stephen A, Hayes, John D

“…Peroxisome proliferator-activated receptor gamma (PPARgamma) is a critical regulator of adipocyte differentiation. Whilst 15-deoxy-delta(12,14)-prostaglandin…”
Get full text

v- and t-SNARE Protein Expression in Models of Insulin Resistance by Maier, Valerie H, Melvin, Derek R, Lister, Carolyn A, Chapman, Helen, Gould, Gwyn W, Murphy, Gregory J

Get full text

Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein Gi by Pyne, Nigel J., Murphy, Gregory J., Milligan, Graeme, Houslay, Miles D.

“…The antiserum AS7 can specifically immunoprecipitate α‐Gi from membrane extracts as well as from a mixture of purified α‐Gi and α‐Go. as ascertained using…”
Get full text

Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein G i by Pyne, Nigel J., Murphy, Gregory J., Milligan, Graeme, Houslay, Miles D.

“…The antiserum AS7 can specifically immunoprecipitate α-G i from membrane extracts as well as from a mixture of purified α-G i and α-G o. as ascertained using […”
Get full text

Assessment of Gi function in an animal model of non-insulin dependent diabetes by Murphy, G J, Kirkham, D M, Cawthorne, M A, Young, P

Get more information

Renal actions of atrial natriuretic factor: modulation of effect by changes in sodium status and aldosterone by Yates, N A, Coghlan, J P, Murphy, G J, Scoggins, B A, McDougall, J G

“…To examine the effect of changes in Na status on the renal response to atrial natriuretic factor (ANF), human ANF-(99-126) was infused into the renal artery of…”
Get full text