Search Results - "Murphy, GM"

Pharmacogenetics of Antidepressant Medication Intolerance by Murphy, Greer M., Kremer, Charlotte, Rodrigues, Heidi E., Schatzberg, Alan F.

“…OBJECTIVE: The authors sought to identify genetic markers for antidepressant medication intolerance. Genetic variation in drug metabolizing enzymes such as…”
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Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro by Lue, Lih-Fen, Rydel, Russell, Brigham, Elizabeth F., Yang, Li-Bang, Hampel, Harald, Murphy Jr, Greer M., Brachova, Libuse, Yan, Shi-Du, Walker, Douglas G., Shen, Yong, Rogers, Joseph

“…We have previously developed and characterized isolated microglia and astrocyte cultures from rapid (<4 h) brain autopsies of Alzheimer's disease (AD) and…”
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The effect of cannabidiol (CBD) on low-frequency activity and functional connectivity in the brain of adults with and without autism spectrum disorder (ASD) by Pretzsch, Charlotte M, Voinescu, Bogdan, Mendez, Maria A, Wichers, Robert, Ajram, Laura, Ivin, Glynis, Heasman, Martin, Williams, Steven, Murphy, Declan GM, Daly, Eileen, McAlonan, Gráinne M

“…Background: The potential benefits of cannabis and its major non-intoxicating component cannabidiol (CBD) are attracting attention, including as a potential…”
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Microglial overexpression of the M-CSF receptor augments phagocytosis of opsonized Aβ by Mitrasinovic, Olivera M., Murphy, Greer M.

“…The role of microglia in Alzheimer’s disease (AD) has come under intense scrutiny recently because microglia may clear amyloid beta (Aβ) by phagocytosis after…”
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Accelerated Phagocytosis of Amyloid-β by Mouse and Human Microglia Overexpressing the Macrophage Colony-stimulating Factor Receptor by Mitrasinovic, Olivera M., Murphy, Greer M.

“…Microglia surrounding Aβ plaques in Alzheimer's disease and in the APPV717F transgenic mouse model of Alzheimer's disease have enhanced immunoreactivity for…”
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Analysis of neuronal gene expression with laser capture microdissection by Vincent, Valerie A.M., DeVoss, Jason J., Ryan, Heather S., Murphy Jr, Greer M.

“…The brain is a heterogeneous tissue in which the numbers of neurons, glia, and other cell types vary among anatomic regions. Gene expression studies performed…”
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Adults with autism spectrum disorder and the criminal justice system: An investigation of prevalence of contact with the criminal justice system, risk factors and sex differences in a specialist assessment service by Blackmore, Charlotte E, Woodhouse, Emma L, Gillan, Nicola, Wilson, Ellie, Ashwood, Karen L, Stoencheva, Vladimira, Nolan, Alexandra, McAlonan, Grainne M, Robertson, Dene M, Whitwell, Susannah, Deeley, Quinton, Craig, Michael C, Zinkstok, Janneke, Wichers, Rob, Spain, Debbie, Roberts, Ged, Murphy, Declan GM, Murphy, Clodagh M, Daly, Eileen

“…The behavioural and cognitive difficulties of some adults with autism spectrum disorder (ASD) may increase their risk of contact with the criminal justice…”
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Proinflammatory effects of M-CSF and Aβ in hippocampal organotypic cultures by Vincent, Valerie A.M., Selwood, Simon P., Murphy, Greer M.

“…Macrophage colony stimulating factor (M-CSF) is a microglial activator expressed at increased levels in the brain in Alzheimer’s disease. In monotypic…”
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Public-Private Partnership: A New Engine for Translational Research in Neurosciences by Murphy, Declan G.M., Goldman, Michel, Loth, Eva, Spooren, Will

“…We have made little recent progress developing effective new treatments for neuropsychiatric and neurodevelopmental disorders. Novel molecular mechanisms have…”
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β-Amyloid Peptide Secretion by a Microglial Cell Line Is Induced by β-Amyloid-(25–35) and Lipopolysaccharide by Bitting, Louise, Naidu, Asha, Cordell, Barbara, Murphy, Greer M.

“…β-Amyloid protein (βAP) deposition is a neuropathologic hallmark of Alzheimer's disease (AD). Yet, the source of cerebral βAP in AD is controversial. We…”
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P3 beta-amyloid peptide has a unique and potentially pathogenic immunohistochemical profile in Alzheimer's disease brain by Higgins, LS, Murphy, GM, Jr, Forno, LS, Catalano, R, Cordell, B

“…The presence of beta-amyloid in brain tissue is characteristic of Alzheimer's disease (AD). A naturally occurring derivative of the beta-amyloid peptide, p3,…”
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The Women's Health Initiative Memory Study: findings and implications for treatment by Craig, Michael C, Maki, Pauline M, Murphy, Declan G M

“…The population of the developed world is ageing; consequently there is an increasing prevalence of age-related neuropsychiatric disorders, such as dementia of…”
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Inhibition of β‐Amyloid Formation by Haloperidol: A Possible Mechanism for Reduced Frequency of Alzheimer's Disease Pathology in Schizophrenia by Higaki, Jeffrey, Murphy, Greer M., Cordell, Barbara

“…: Several reports have suggested that the frequency of Alzheimer's disease (AD) neuropathology is significantly reduced in elderly individuals with…”
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A population-based study of skin cancer incidence and prevalence in renal transplant recipients by Moloney, F.J., Comber, H., O'Lorcain, P., O'Kelly, P., Conlon, P.J., Murphy, G.M.

“…Summary Background  Cancers occurring following solid organ transplantation are a rapidly growing public health concern. Defining the extent of the problem has…”
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Antibodies to presenilin proteins detect neurofibrillary tangles in Alzheimer's disease by Murphy, GM, Jr, Forno, LS, Ellis, WG, Nochlin, D, Levy-Lahad, E, Poorkaj, P, Bird, TD, Jiang, Z, Cordell, B

“…Mutations in the presenilin (PS)-1 and PS-2 genes have been shown to be linked with the development of Alzheimer's disease (AD). We examined Alzheimer's brain…”
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Pharmacogenetics of Psychotropic Drug Response by Malhotra, Anil K., Murphy, Greer M., Kennedy, James L.

“…OBJECTIVE: Molecular genetic approaches provide a novel method of dissecting the heterogeneity of psychotropic drug response. These pharmacogenetic strategies…”
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Low-dose ultraviolet-B irradiation depletes human epidermal Langerhans cells by Murphy, G M, Norris, P G, Young, A R, Corbett, M F, Hawk, J L

“…We have examined the effects of low-dose monochromatic UVB irradiation (295 +/- 5 nm), biologically equivalent to that generally incident on the skin during a…”
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Aberrant gene expression with deficient apoptotic keratinocyte clearance may predispose to polymorphic light eruption by Lembo, S., Hawk, J.L.M., Murphy, G.M., Kaneko, K., Young, A.R., McGregor, J.M., Walker, S.L., Palmer, R.A.

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Development of a monoclonal antibody specific for the COOH-terminal of beta-amyloid 1-42 and its immunohistochemical reactivity in Alzheimer's disease and related disorders by Murphy, GM, Jr, Forno, LS, Higgins, L, Scardina, JM, Eng, LF, Cordell, B

“…The beta-amyloid peptide (beta AP) has been characterized by protein sequencing techniques as a 39-43 amino acid protein with heterogeneous COOH-termini…”
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Exposure to and Content of Marijuana Product Reviews by Cavazos-Rehg, Patricia A., Krauss, Melissa J., Sowles, Shaina J., Murphy, Gabrielle M., Bierut, Laura J.

“…Many individuals now seek out product reviews in order to make an informed decision prior to making a purchase. In this study, we investigate consumers’…”
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