Search Results - "Murphy, D. L"

What's wrong with my mouse model? Advances and strategies in animal modeling of anxiety and depression by KALUEFF, A. V, WHEATON, M, MURPHY, D. L

“…Stress plays a key role in pathogenesis of anxiety and depression. Animal models of these disorders are widely used in behavioral neuroscience to explore…”
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Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531 by WENDLAND, J. R, MARTIN, B. J, KRUSE, M. R, LESCH, K.-P, MURPHY, D. L

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Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective by Bienvenu, O J, Samuels, J F, Wuyek, L A, Liang, K-Y, Wang, Y, Grados, M A, Cullen, B A, Riddle, M A, Greenberg, B D, Rasmussen, S A, Fyer, A J, Pinto, A, Rauch, S L, Pauls, D L, McCracken, J T, Piacentini, J, Murphy, D L, Knowles, J A, Nestadt, G

“…Experts have proposed removing obsessive-compulsive disorder (OCD) from the anxiety disorders section and grouping it with putatively related conditions in…”
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Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice by Wellman, C L, Izquierdo, A, Garrett, J E, Martin, K P, Carroll, J, Millstein, R, Lesch, K-P, Murphy, D L, Holmes, A

“…A lesser-expressing form of the human 5-HT transporter (5-HTT) gene has been associated with increased fear and anxiety and vulnerability to the effects of…”
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Accumulation of abasic sites induces genomic instability in normal human gastric epithelial cells during Helicobacter pylori infection by Kidane, D, Murphy, D L, Sweasy, J B

“…Helicobacter pylori infection of the human stomach is associated with inflammation that leads to the release of reactive oxygen and nitrogen species (RONs),…”
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Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype by OZAKI, N, GOLDMAN, D, KAYE, W. H, PLOTNICOV, K, GREENBERG, B. D, LAPPALAINEN, J, RUDNICK, G, MURPHY, D. L

“…Two common serotonin transporter (SERT) untranslated region gene variants have been intensively studied, but remain inconclusively linked to depression and…”
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Hypolocomotion, anxiety and serotonin syndrome‐like behavior contribute to the complex phenotype of serotonin transporter knockout mice by Kalueff, A. V., Fox, M. A., Gallagher, P. S., Murphy, D. L.

“…Although mice with a targeted disruption of the serotonin transporter (SERT) have been studied extensively using various tests, their complex behavioral…”
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Social approach in genetically engineered mouse lines relevant to autism by Moy, S. S., Nadler, J. J., Young, N. B., Nonneman, R. J., Grossman, A. W., Murphy, D. L., D’Ercole, A. J., Crawley, J. N., Magnuson, T. R., Lauder, J. M.

“…Profound impairment in social interaction is a core symptom of autism, a severe neurodevelopmental disorder. Deficits can include a lack of interest in social…”
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Abnormal anxiety‐related behavior in serotonin transporter null mutant mice: the influence of genetic background by Holmes, A., Li, Q., Murphy, D. L., Gold, E., Crawley, J. N.

“…Serotonin transporter (5‐HTT) null mutant mice provide a model system to study the role genetic variation in the 5‐HTT plays in the regulation of emotion…”
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Implementation Evaluation of a Complex Intervention to Improve Timeliness of Care for Veterans with Transient Ischemic Attack by Damush, T. M., Miech, E. J., Rattray, N. A., Homoya, B., Penney, Lauren S., Cheatham, A., Baird, S., Myers, J, Austin, C., Myers, L J, Perkins, A J, Zhang, Y., Giacherio, B., Kumar, M, Murphy, LD, Sico, J J., Bravata, D. M.

“…ABSTRACT Background The Protocol-guided Rapid Evaluation of Veterans Experiencing New Transient Neurologic Symptoms (PREVENT) program was designed to address…”
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Effects of MDMA on Extracellular Dopamine and Serotonin Levels in Mice Lacking Dopamine and/or Serotonin Transporters by Hagino, Y, Takamatsu, Y, Yamamoto, H, Iwamura, T, Murphy, D L, Uhl, G R, Sora, I, Ikeda, K

“…3,4-Methylendioxymethamphetamine (MDMA) has both stimulatory and hallucinogenic properties which make its psychoactive effects unique and different from those…”
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Altered Neocortical Cell Density and Layer Thickness in Serotonin Transporter Knockout Mice: A Quantitation Study by Altamura, C, Dell'Acqua, ML, Moessner, R, Murphy, DL, Lesch, KP, Persico, Antonio M.

“…The neurotransmitter serotonin (5-HT) plays morphogenetic roles during development, and their alteration could contribute to autism pathogenesis in humans. To…”
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Whole-genome association analysis of treatment response in obsessive-compulsive disorder by Qin, H, Samuels, J F, Wang, Y, Zhu, Y, Grados, M A, Riddle, M A, Greenberg, B D, Knowles, J A, Fyer, A J, McCracken, J T, Murphy, D L, Rasmussen, S A, Cullen, B A, Piacentini, J, Geller, D, Stewart, S E, Pauls, D, Bienvenu, O J, Goes, F S, Maher, B, Pulver, A E, Valle, D, Lange, C, Mattheisen, M, McLaughlin, N C, Liang, K-Y, Nurmi, E L, Askland, K D, Nestadt, G, Shugart, Y Y

“…Up to 30% of patients with obsessive-compulsive disorder (OCD) exhibit an inadequate response to serotonin reuptake inhibitors (SRIs). To date, genetic…”
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Neuroimaging of neuronal circuits involved in tic generation in patients with Tourette syndrome by LERNER, A, BAGIC, A, SATO, S, MURPHY, D. L, HALLETT, M, BOUDREAU, E. A, HANAKAWA, T, PAGAN, F, MARI, Z, BARA-JIMENEZ, W, AKSU, M, GARRAUX, G, SIMMONS, J. M

“…To identify brain regions generating tics in patients with Tourette syndrome using sleep as a baseline. We used [15O]H2O PET to study nine patients with…”
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Obsessive-compulsive disorder: subclassification based on co-morbidity by Nestadt, G, Di, C Z, Riddle, M A, Grados, M A, Greenberg, B D, Fyer, A J, McCracken, J T, Rauch, S L, Murphy, D L, Rasmussen, S A, Cullen, B, Pinto, A, Knowles, J A, Piacentini, J, Pauls, D L, Bienvenu, O J, Wang, Y, Liang, K Y, Samuels, J F, Roche, K Bandeen

“…Obsessive-compulsive disorder (OCD) is probably an etiologically heterogeneous condition. Many patients manifest other psychiatric syndromes. This study…”
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Multiple rare SAPAP3 missense variants in trichotillomania and OCD by Züchner, S, Wendland, J R, Ashley-Koch, A E, Collins, A L, Tran-Viet, K N, Quinn, K, Timpano, K C, Cuccaro, M L, Pericak-Vance, M A, Steffens, D C, Krishnan, K R, Feng, G, Murphy, D L

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A family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder in 378 families by Shugart, Y.Y., Wang, Y., Samuels, J.F., Grados, M.A., Greenberg, B.D., Knowles, J.A., McCracken, J.T., Rauch, S.L., Murphy, D.L., Rasmussen, S.A., Cullen, B., Hoehn-Saric, R., Pinto, A., Fyer, A.J., Piacentini, J., Pauls, D.L., Bienvenu, O.J., Riddle, M.A., Liang, K.Y., Nestadt, G.

“…SLC1A encodes the neuronal and epithelial glutamate transporter and was previously tested as a candidate for obsessive–compulsive disorder (OCD) by several…”
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Association of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study by Voyiaziakis, E, Evgrafov, O, Li, D, Yoon, H-J, Tabares, P, Samuels, J, Wang, Y, Riddle, M A, Grados, M A, Bienvenu, O J, Shugart, Y Y, Liang, K-Y, Greenberg, B D, Rasmussen, S A, Murphy, D L, Wendland, J R, McCracken, J T, Piacentini, J, Rauch, S L, Pauls, D L, Nestadt, G, Fyer, A J, Knowles, J A

“…Genetic association studies of SLC6A4 ( SERT ) and obsessive-compulsive disorder (OCD) have been equivocal. We genotyped 1241 individuals in 278 pedigrees from…”
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Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q by SHUGART, Y. Y, SAMUELS, J, PINTO, A, FYER, A. J, PIACENTINI, J, PAULS, D. L, CULLEN, B, PAGE, J, RASMUSSEN, S. A, BIENVENU, O. J, HOEHN-SARIC, R, VALLE, D, WILLOUR, V. L, LIANG, K.-Y, RIDDLE, M. A, NESTADT, G, GRADOS, M. A, GREENBERG, B. D, KNOWLES, J. A, MCCRACKEN, J. T, RAUCH, S. L, MURPHY, D. L, WANG, Y

“…Obsessive-compulsive disorder (OCD) is the tenth most disabling medical condition worldwide. Twin and family studies implicate a genetic etiology for this…”
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Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking by Benjamin, Jonathan, Li, Lin, Patterson, Chavis, Greenberg, Benjamin D, Murphy, Dennis L, Hamer, Dean H

“…Twin and adoption studies suggest that 30 to 60% of the variance in many personality traits is due to inherited factors. However, there is little knowledge of…”
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