Search Results - "Murphy, Connor T"

γPNA FRET Pair Miniprobes for Quantitative Fluorescent In Situ Hybridization to Telomeric DNA in Cells and Tissue by Orenstein, Alexander, Berlyoung, April S, Rastede, Elizabeth E, Pham, Ha H, Fouquerel, Elise, Murphy, Connor T, Leibowitz, Brian J, Yu, Jian, Srivastava, Tumul, Armitage, Bruce A, Opresko, Patricia L

“…Measurement of telomere length by fluorescent in situ hybridization is widely used for biomedical and epidemiological research, but there has been relatively…”
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Loop and Backbone Modifications of Peptide Nucleic Acid Improve G-Quadruplex Binding Selectivity by Lusvarghi, Sabrina, Murphy, Connor T, Roy, Subhadeep, Tanious, Farial A, Sacui, Iulia, Wilson, W. David, Ly, Danith H, Armitage, Bruce A

“…Targeting guanine (G) quadruplex structures is an exciting new strategy with potential for controlling gene expression and designing anticancer agents…”
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Polymeric cGAMP microparticles affect the immunogenicity of a broadly active influenza mRNA lipid nanoparticle vaccine by Hendy, Dylan A., Ma, Yutian, Dixon, Timothy A., Murphy, Connor T., Pena, Erik S., Carlock, Michael A., Ross, Ted M., Bachelder, Eric M., Ainslie, Kristy M., Fenton, Owen S.

“…Influenza outbreaks are a major burden worldwide annually. While seasonal vaccines do provide protection against infection, they are limited in that they need…”
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Telomeres are partly shielded from ultraviolet-induced damage and proficient for nucleotide excision repair of photoproducts by Parikh, Dhvani, Fouquerel, Elise, Murphy, Connor T., Wang, Hong, Opresko, Patricia L.

“…Ultraviolet light induces cyclobutane pyrimidine dimers (CPD) and pyrimidine(6–4)pyrimidone photoproducts, which interfere with DNA replication and…”
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Hybridization of G‑Quadruplex-Forming Peptide Nucleic Acids to Guanine-Rich DNA Templates Inhibits DNA Polymerase η Extension by Murphy, Connor T, Gupta, Anisha, Armitage, Bruce A, Opresko, Patricia L

“…The guanine quadruplex (G-quadruplex) is a highly stable secondary structure that forms in G-rich repeats of DNA, which can interfere with DNA processes,…”
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DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation by Lormand, Justin D, Buncher, Noah, Murphy, Connor T, Kaur, Parminder, Lee, Marietta Y, Burgers, Peter, Wang, Hong, Kunkel, Thomas A, Opresko, Patricia L

“…Previous evidence indicates that telomeres resemble common fragile sites and present a challenge for DNA replication. The precise impediments to replication…”
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Cooperative hybridization of γPNA miniprobes to a repeating sequence motif and application to telomere analysis by Pham, Ha H, Murphy, Connor T, Sureshkumar, Gopalsamy, Ly, Danith H, Opresko, Patricia L, Armitage, Bruce A

“…GammaPNA oligomers having one or two repeats of the sequence AATCCC were designed to hybridize to DNA having one or more repeats of the complementary TTAGGG…”
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Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes by Roy, Subhadeep, Zanotti, Kimberly J, Murphy, Connor T, Tanious, Farial A, Wilson, W David, Ly, Danith H, Armitage, Bruce A

“…Guanine-rich peptide nucleic acid probes hybridize to DNA G quadruplex targets with high affinity, forming PNA-DNA heteroquadruplexes. We report a surprising…”
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Loop and Backbone Modifications of PNA Improve G-Quadruplex Binding Selectivity by Lusvarghi, Sabrina, Murphy, Connor T., Roy, Subhadeep, Tanious, Farial A., Sacui, Iulia, Wilson, W. David, Ly, Danith H., Armitage, Bruce A.

“…Targeting guanine (G) quadruplex structures is an exciting new strategy with potential for controlling gene expression and designing anticancer agents…”
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Optimization of Guanine Quadruplex-targeted Peptide Nucleic Acids by Murphy, Connor T

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Optimization of Guanine Quadruplex-targeted Peptide Nucleic Acids by Murphy, Connor T

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