Search Results - "Murphy, Bruce"

Under Arrest: The Embryo in Diapause by Murphy, Bruce D.

“…Embryonic diapause is the reversible arrest in development of mammalian embryos at the blastocyst stage. In this issue of Developmental Cell, Hussein et al…”
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The Orphan Nuclear Receptors Steroidogenic Factor-1 and Liver Receptor Homolog-1: Structure, Regulation, and Essential Roles in Mammalian Reproduction by Meinsohn, Marie-Charlotte, Smith, Olivia E, Bertolin, Kalyne, Murphy, Bruce D

“…Nuclear receptors are intracellular proteins that act as transcription factors. Proteins with classic nuclear receptor domain structure lacking identified…”
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Elucidating evolutionarily conserved mechanisms of diapause regulation using an in silico approach by Ajit, Kamal, Murphy, Bruce D., Banerjee, Arnab

“…Embryonic diapause is an enigmatic phenomenon that appears in diverse species. Although regulatory mechanisms have been established, there is much to be…”
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Nuclear receptors: Key regulators of somatic cell functions in the ovulatory process by Hughes, Camilla H.K., Murphy, Bruce D.

“…The development of the ovarian follicle to its culmination by ovulation is an essential element of fertility. The final stages of ovarian follicular growth are…”
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Embryonic diapause: development on hold by Fenelon, Jane C, Banerjee, Arnab, Murphy, Bruce D

“…Embryonic diapause, the temporary suspension of development of the embryo, is a fascinating reproductive strategy that has been frequently exploited across the…”
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Inhibition of polyamine synthesis causes entry of the mouse blastocyst into embryonic diapause by Fenelon, Jane C, Murphy, Bruce D

“…Embryonic diapause is a common reproductive strategy amongst mammals, requiring an intimate cross-talk between the endometrium and the blastocyst. To date, the…”
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Orphan nuclear receptors in angiogenesis and follicular development by Guzmán, Adrian, Hughes, Camilla H K, Murphy, Bruce D

“…Orphan nuclear receptors (ONRs) are a subset of the nuclear receptor family that lacks known endogenous ligands. Among 48 nuclear receptors identified in…”
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The Orphan Nuclear Receptor Nr5a2 Is Essential for Luteinization in the Female Mouse Ovary by Bertolin, Kalyne, Gossen, Jan, Schoonjans, Kristina, Murphy, Bruce D

“…In the ovary, the follicular granulosa cells express the nuclear receptor Nr5a2 (nuclear receptor subfamily 5 group A member 2), also known as liver receptor…”
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Collagen fibre-mediated mechanical damage increases calcification of bovine pericardium for use in bioprosthetic heart valves by Whelan, Alix, Williams, Elizabeth, Fitzpatrick, Emma, Murphy, Bruce P., Gunning, Paul S., O'Reilly, David, Lally, Caitríona

“…In cases of aortic stenosis, bioprosthetic heart valves (BHVs), with glutaraldehyde-fixed bovine pericardium leaflets (GLBP), are often implanted to replace…”
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Liver receptor homolog 1 (LRH-1) regulates follicle vasculature during ovulation in mice by Guzmán, Adrian, Hughes, Camilla H K, Murphy, Bruce D

“…In brief It is well-established that liver receptor homolog 1 (LRH-1/NR5A2) regulates the ovarian function and is required for ovulation and luteinization in…”
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Determination of the tensile mechanical properties of the segmented mitral valve annulus by Gunning, Gillian M, Murphy, Bruce P

“…Abstract The mitral valve annulus is a complex and irregular component of the mitral valve apparatus, serving both a structural and sphincteric role. We have…”
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Applications of mesenchymal stem cell technology in bovine species by Hill, Amanda Baracho Trindade, Bressan, Fabiana Fernandes, Murphy, Bruce D, Garcia, Joaquim Mansano

“…Mesenchymal stem cells (MSCs) have received a great deal of attention over the past 20 years mainly because of the results that showed regeneration potential…”
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Steroidogenic factor 1 (SF-1; Nr5a1 ) regulates the formation of the ovarian reserve by Hughes, Camilla H K, Smith, Olivia E, Meinsohn, Marie-Charlotte, Brunelle, Mylène, Gévry, Nicolas, Murphy, Bruce D

“…The ovarian follicle reserve, formed pre- or perinatally, comprises all oocytes for lifetime reproduction. Depletion of this reserve results in infertility…”
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The role of steroidogenic factor 1 (SF-1) in steroidogenic cell function of the testes and ovaries of mature mice by Smith, Olivia E, Morin, Fanny, Roussel, Vickie, Bertucci, Micka C, Boyer, Alexandre, Murphy, Bruce D

“…In brief The nuclear receptor steroidogenic factor 1 (SF-1) is essential for mature mouse gonad steroidogenic gene expression, for Leydig and Sertoli cell…”
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Liver receptor homolog-1 is essential for pregnancy by Zhang, Cong, Large, Michael J, Duggavathi, Raj, DeMayo, Francesco J, Lydon, John P, Schoonjans, Kristina, Kovanci, Ertug, Murphy, Bruce D

“…Liver receptor homolog-1 is an orphan nuclear receptor. Murphy and colleagues now show that this protein is crucial for different phases of pregnancy,…”
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Nanomedicines for advanced cancer treatments: Transitioning towards responsive systems by van Elk, Merel, Murphy, Bruce P., Eufrásio-da-Silva, Tatiane, O’Reilly, Daniel P., Vermonden, Tina, Hennink, Wim E., Duffy, Garry P., Ruiz-Hernández, Eduardo

“…[Display omitted] The development of nanomedicines for the treatment of cancer focuses on the local targeted delivery of chemotherapeutic drugs to enhance drug…”
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Adiponectin action from head to toe by Brochu-Gaudreau, Karine, Rehfeldt, Charlotte, Blouin, Richard, Bordignon, V., Murphy, Bruce D., Palin, Marie-France

“…Adiponectin, the most abundant protein secreted by white adipose tissue, is known for its involvement in obesity-related disorders such as insulin resistance,…”
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Steroidogenic Factor 1 Regulation of the Hypothalamic-Pituitary-Ovarian Axis of Adult Female Mice by Smith, Olivia E, Roussel, Vickie, Morin, Fanny, Ongaro, Luisina, Zhou, Xiang, Bertucci, Micka C, Bernard, Daniel J, Murphy, Bruce D

“…The orphan nuclear receptor steroidogenic factor-1 (SF-1 or NR5A1) is an indispensable regulator of adrenal and gonadal formation, playing roles in sex…”
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Polyamines on the Reproductive Landscape by Lefèvre, Pavine L. C, Palin, Marie-France, Murphy, Bruce D

“…The polyamines are ubiquitous polycationic compounds. Over the past 40 yr, investigation has shown that some of these, namely spermine, spermidine, and…”
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A role for orphan nuclear receptor liver receptor homolog-1 (LRH-1, NR5A2) in primordial follicle activation by Meinsohn, Marie-Charlotte, Hughes, Camilla H. K., Estienne, Anthony, Saatcioglu, Hatice D., Pépin, David, Duggavathi, Raj, Murphy, Bruce D.

“…Liver receptor homolog-1 (NR5A2) is expressed specifically in granulosa cells of developing ovarian follicles where it regulates the late stages of follicle…”
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