Search Results - "Murphy, Anne N"

Review: Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis by Falconer, Jane, Murphy, Anne N., Young, Stephen P., Clark, Andrew R., Tiziani, Stefano, Guma, Monica, Buckley, Christopher D.

“…Metabolomic studies of body fluids show that immune‐mediated inflammatory diseases such as rheumatoid arthritis (RA) are associated with metabolic disruption…”
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Analysis and interpretation of microplate-based oxygen consumption and pH data by Divakaruni, Ajit S, Paradyse, Alexander, Ferrick, David A, Murphy, Anne N, Jastroch, Martin

“…Breakthrough technologies to measure cellular oxygen consumption and proton efflux are reigniting the study of cellular energetics by increasing the scope and…”
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Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis by Green, Courtney R, Wallace, Martina, Divakaruni, Ajit S, Phillips, Susan A, Murphy, Anne N, Ciaraldi, Theodore P, Metallo, Christian M

“…Stable-isotope tracing and metabolomics analysis comparing pre-adipocytes and differentiated adipocytes revealed a shift from glucose and glutamine utilization…”
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Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast‐like Synoviocytes by Garcia‐Carbonell, Ricard, Divakaruni, Ajit S., Lodi, Alessia, Vicente‐Suarez, Ildefonso, Saha, Arindam, Cheroutre, Hilde, Boss, Gerry R., Tiziani, Stefano, Murphy, Anne N., Guma, Monica

“…Objective Up‐regulation of glucose metabolism has been implicated not only in tumor cell growth but also in immune cells upon activation. However, little is…”
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Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier by Vacanti, Nathaniel M., Divakaruni, Ajit S., Green, Courtney R., Parker, Seth J., Henry, Robert R., Ciaraldi, Theodore P., Murphy, Anne N., Metallo, Christian M.

“…Pyruvate lies at a central biochemical node connecting carbohydrate, amino acid, and fatty acid metabolism, and the regulation of pyruvate flux into…”
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High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria by Rogers, George W, Brand, Martin D, Petrosyan, Susanna, Ashok, Deepthi, Elorza, Alvaro A, Ferrick, David A, Murphy, Anne N

“…Recently developed technologies have enabled multi-well measurement of O(2) consumption, facilitating the rate of mitochondrial research, particularly…”
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Parkin Protein Deficiency Exacerbates Cardiac Injury and Reduces Survival following Myocardial Infarction by Kubli, Dieter A., Zhang, Xiaoxue, Lee, Youngil, Hanna, Rita A., Quinsay, Melissa N., Nguyen, Christine K., Jimenez, Rebecca, Petrosyan, Susanna, Murphy, Anne N., Gustafsson, Åsa B.

“…It is known that loss-of-function mutations in the gene encoding Parkin lead to development of Parkinson disease. Recently, Parkin was found to play an…”
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Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury by Cordes, Thekla, Lucas, Alfredo, Divakaruni, Ajit S., Murphy, Anne N., Cabrales, Pedro, Metallo, Christian M.

“…Cerebral ischemia/reperfusion (IR) drives oxidative stress and injurious metabolic processes that lead to redox imbalance, inflammation, and tissue damage…”
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Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions by Zhang, Hui, Badur, Mehmet G., Divakaruni, Ajit S., Parker, Seth J., Jäger, Christian, Hiller, Karsten, Murphy, Anne N., Metallo, Christian M.

“…Recent studies have suggested that human pluripotent stem cells (hPSCs) depend primarily on glycolysis and only increase oxidative metabolism during…”
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Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death by Ding, Boxiao, Parmigiani, Anita, Divakaruni, Ajit S., Archer, Kellie, Murphy, Anne N., Budanov, Andrei V.

“…Sestrin2 is a member of a family of stress responsive proteins, which controls cell viability via antioxidant activity and regulation of the mammalian target…”
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ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function by Darshi, Manjula, Mendiola, Vincent L., Mackey, Mason R., Murphy, Anne N., Koller, Antonius, Perkins, Guy A., Ellisman, Mark H., Taylor, Susan S.

“…The mitochondrial inner membrane (IM) serves as the site for ATP production by hosting the oxidative phosphorylation complex machinery most notably on the…”
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IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism by GRASSIAN, Alexandra R, PARKER, Seth J, JOUD-CALDWELL, Carol, CHUNG, Franklin, HONG YIN, HANDLY, Erika D, STRAUB, Christopher, GROWNEY, Joseph D, HEIDEN, Matthew G. Vander, MURPHY, Anne N, PAGLIARINI, Raymond, METALLO, Christian M, DAVIDSON, Shawn M, DIVAKARUNI, Ajit S, GREEN, Courtney R, XIAMEI ZHANG, SLOCUM, Kelly L, MINYING PU, LIN, Fallon, VICKERS, Chad

“…Oncogenic mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in several types of cancer, but the metabolic consequences of these genetic changes are…”
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Sub-nanowatt microfluidic single-cell calorimetry by Hong, Sahngki, Dechaumphai, Edward, Green, Courtney R., Lal, Ratneshwar, Murphy, Anne N., Metallo, Christian M., Chen, Renkun

“…Non-invasive and label-free calorimetry could become a disruptive technique to study single cell metabolic heat production without altering the cell behavior,…”
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Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier by Divakaruni, Ajit S., Wiley, Sandra E., Rogers, George W., Andreyev, Alexander Y., Petrosyan, Susanna, Loviscach, Mattias, Wall, Estelle A., Yadava, Nagendra, Heuck, Alejandro P., Ferrick, David A., Henry, Robert R., McDonald, William G., Colca, Jerry R., Simon, Melvin I., Ciaraldi, Theodore P., Murphy, Anne N.

“…Facilitated pyruvate transport across the mitochondrial inner membrane is a critical step in carbohydrate, amino acid, and lipid metabolism. We report that…”
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NaCT/SLC13A5 facilitates citrate import and metabolism under nutrient-limited conditions by Kumar, Avi, Cordes, Thekla, Thalacker-Mercer, Anna E., Pajor, Ana M., Murphy, Anne N., Metallo, Christian M.

“…Citrate lies at a critical node of metabolism, linking tricarboxylic acid metabolism and lipogenesis via acetyl-coenzyme A. Recent studies have observed that…”
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Mitochondrial Phosphatase PTPMT1 Is Essential for Cardiolipin Biosynthesis by Zhang, Ji, Guan, Ziqiang, Murphy, Anne N., Wiley, Sandra E., Perkins, Guy A., Worby, Carolyn A., Engel, James L., Heacock, Philip, Nguyen, Oanh Kim, Wang, Jonathan H., Raetz, Christian R.H., Dowhan, William, Dixon, Jack E.

“…PTPMT1 was the first protein tyrosine phosphatase found localized to the mitochondria, but its biological function was unknown. Herein, we demonstrate…”
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Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells by Wu, Xingyu, Yeerna, Huwate, Goto, Yusuke, Ando, Toshinori, Wu, Victoria H, Zhang, Xuefeng, Wang, Zhiyong, Amornphimoltham, Panomwat, Murphy, Anne N, Tamayo, Pablo, Chen, Qianming, Lippman, Scott M, Gutkind, J Silvio

“…Metformin may reduce the progression of head and neck squamous cell carcinoma (HNSCC); however, whether metformin acts by altering the host metabolism or…”
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HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders by Fields, Jerel Adam, Serger, Elisabeth, Campos, Sofia, Divakaruni, Ajit S, Kim, Changyoun, Smith, Kendall, Trejo, Margarita, Adame, Anthony, Spencer, Brian, Rockenstein, Edward, Murphy, Anne N, Ellis, Ronald J, Letendre, Scott, Grant, Igor, Masliah, Eliezer

“…Abstract HIV-associated neurocognitive disorders (HAND) still occur in approximately 50% of HIV patients, and therapies to combat HAND progression are urgently…”
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Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state by Kushnareva, Yulia, Murphy, Anne N, Andreyev, Alexander

“…Several lines of evidence indicate that mitochondrial reactive oxygen species (ROS) generation is the major source of oxidative stress in the cell. It has been…”
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Elevated PGC-1α Activity Sustains Mitochondrial Biogenesis and Muscle Function without Extending Survival in a Mouse Model of Inherited ALS by Da Cruz, Sandrine, Parone, Philippe A., Lopes, Vanda S., Lillo, Concepción, McAlonis-Downes, Melissa, Lee, Sandra K., Vetto, Anne P., Petrosyan, Susanna, Marsala, Martin, Murphy, Anne N., Williams, David S., Spiegelman, Bruce M., Cleveland, Don W.

“…The transcriptional coactivator PGC-1α induces multiple effects on muscle, including increased mitochondrial mass and activity. Amyotrophic lateral sclerosis…”
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