Search Results - "Muroyama, Ryosuke"

The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels by Shibata, Chikako, Ohno, Motoko, Otsuka, Motoyuki, Kishikawa, Takahiro, Goto, Kaku, Muroyama, Ryosuke, Kato, Naoya, Yoshikawa, Takeshi, Takata, Akemi, Koike, Kazuhiko

“…Abstract Despite recent progress in the development of direct-acting antivirals against hepatitis C virus (HCV), chronic HCV infection remains an important…”
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Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma by Kumar, Vinod, Kato, Naoya, Urabe, Yuji, Takahashi, Atsushi, Muroyama, Ryosuke, Hosono, Naoya, Otsuka, Motoyuki, Tateishi, Ryosuke, Omata, Masao, Nakagawa, Hidewaki, Koike, Kazuhiko, Kamatani, Naoyuki, Kubo, Michiaki, Nakamura, Yusuke, Matsuda, Koichi

“…Koichi Matsuda and colleagues report a genome-wide association study for hepatitis C virus–induced hepatocellular carcinoma. They identify a susceptibility…”
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The impact of FGF19/FGFR4 signaling inhibition in antitumor activity of multi-kinase inhibitors in hepatocellular carcinoma by Kanzaki, Hiroaki, Chiba, Tetsuhiro, Ao, Junjie, Koroki, Keisuke, Kanayama, Kengo, Maruta, Susumu, Maeda, Takahiro, Kusakabe, Yuko, Kobayashi, Kazufumi, Kanogawa, Naoya, Kiyono, Soichiro, Nakamura, Masato, Kondo, Takayuki, Saito, Tomoko, Nakagawa, Ryo, Ogasawara, Sadahisa, Suzuki, Eiichiro, Ooka, Yoshihiko, Muroyama, Ryosuke, Nakamoto, Shingo, Yasui, Shin, Tawada, Akinobu, Arai, Makoto, Kanda, Tatsuo, Maruyama, Hitoshi, Mimura, Naoya, Kato, Jun, Zen, Yoh, Ohtsuka, Masayuki, Iwama, Atsushi, Kato, Naoya

“…FGF19/FGFR4 autocrine signaling is one of the main targets for multi-kinase inhibitors (MKIs). However, the molecular mechanisms underlying FGF19/FGFR4…”
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EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma by Kusakabe, Yuko, Chiba, Tetsuhiro, Oshima, Motohiko, Koide, Shuhei, Rizq, Ola, Aoyama, Kazumasa, Ao, Junjie, Kaneko, Tatsuya, Kanzaki, Hiroaki, Kanayama, Kengo, Maeda, Takahiro, Saito, Tomoko, Nakagawa, Ryo, Kobayashi, Kazufumi, Kiyono, Soichiro, Nakamura, Masato, Ogasawara, Sadahisa, Suzuki, Eiichiro, Nakamoto, Shingo, Yasui, Shin, Mikata, Rintaro, Muroyama, Ryosuke, Kanda, Tatsuo, Maruyama, Hitoshi, Kato, Jun, Mimura, Naoya, Ma, Anqi, Jin, Jian, Zen, Yoh, Otsuka, Masayuki, Kaneda, Atsushi, Iwama, Atsushi, Kato, Naoya

“…Both EZH2 and its homolog EZH1 function as histone H3 Lysine 27 (H3K27) methyltransferases and repress the transcription of target genes. Dysregulation of…”
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Leukotriene receptor antagonists enhance HCC treatment efficacy by inhibiting ADAMs and suppressing MICA shedding by Arai, Jun, Goto, Kaku, Otoyama, Yumi, Nakajima, Yoko, Sugiura, Ikuya, Kajiwara, Atsushi, Tojo, Masayuki, Ichikawa, Yuki, Uozumi, Shojiro, Shimozuma, Yuu, Uchikoshi, Manabu, Sakaki, Masashi, Nozawa, Hisako, Nakagawa, Ryo, Muroyama, Ryosuke, Kato, Naoya, Yoshida, Hitoshi

“…In our previous genome-wide association study, we demonstrated the association between MHC class I-related chain A (MICA) and hepatocellular carcinoma (HCC)…”
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Enzymatic inhibition of MICA sheddase ADAM17 by lomofungin in hepatocellular carcinoma cells by Arai, Jun, Goto, Kaku, Tanoue, Yasushi, Ito, Sayaka, Muroyama, Ryosuke, Matsubara, Yasuo, Nakagawa, Ryo, Kaise, Yoshimi, Lim, Lay Ahyoung, Yoshida, Hitoshi, Kato, Naoya

“…In our previous study on hepatocellular carcinoma (HCC) susceptibility genes in chronic hepatitis patients, we identified the MHC class I polypeptide‐related…”
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Serum fibroblast growth factor 19 serves as a potential novel biomarker for hepatocellular carcinoma by Maeda, Takahiro, Kanzaki, Hiroaki, Chiba, Tetsuhiro, Ao, Junjie, Kanayama, Kengo, Maruta, Susumu, Kusakabe, Yuko, Saito, Tomoko, Kobayashi, Kazufumi, Kiyono, Soichiro, Nakamura, Masato, Ogasawara, Sadahisa, Suzuki, Eiichiro, Ooka, Yoshihiko, Nakamoto, Shingo, Nakagawa, Ryo, Muroyama, Ryosuke, Kanda, Tatsuo, Maruyama, Hitoshi, Kato, Naoya

“…Abnormal autocrine fibroblast growth factor 19 (FGF19) production has been observed in several types of cancers, including hepatocellular carcinoma (HCC). In…”
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The RNA-Binding Protein ELAVL1 Regulates Hepatitis B Virus Replication and Growth of Hepatocellular Carcinoma Cells by Kanzaki, Hiroaki, Chiba, Tetsuhiro, Kaneko, Tatsuya, Ao, Junjie, Kan, Motoyasu, Muroyama, Ryosuke, Nakamoto, Shingo, Kanda, Tatsuo, Maruyama, Hitoshi, Kato, Jun, Zen, Yoh, Kotani, Ai, Sekiba, Kazuma, Otsuka, Motoyuki, Ohtsuka, Masayuki, Kato, Naoya

“…Previous RNA immunoprecipitation followed by proteomic approaches successfully demonstrated that Embryonic Lethal, Abnormal Vision, Drosophila-Like 1 (ELAVL1)…”
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Predominance of regorafenib over sorafenib: Restoration of membrane‐bound MICA in hepatocellular carcinoma cells by Arai, Jun, Goto, Kaku, Stephanou, Anthony, Tanoue, Yasushi, Ito, Sayaka, Muroyama, Ryosuke, Matsubara, Yasuo, Nakagawa, Ryo, Morimoto, Sayuri, Kaise, Yoshimi, Lim, Lay Ahyoung, Yoshida, Hitoshi, Kato, Naoya

“…Background and Aim The multi‐kinase inhibitor regorafenib (REG) was recently demonstrated to be effective in patients with sorafenib (SOR)‐resistant…”
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Liver biopsy technique in the era of genomic cancer therapies: a single-center retrospective analysis by Ozeki, Yusuke, Kanogawa, Naoya, Ogasawara, Sadahisa, Ogawa, Keita, Ishino, Takamasa, Nakagawa, Miyuki, Fujiwara, Kisako, Unozawa, Hidemi, Iwanaga, Terunao, Sakuma, Takafumi, Fujita, Naoto, Kojima, Ryuta, Kanzaki, Hiroaki, Koroki, Keisuke, Kobayashi, Kazufumi, Nakamura, Masato, Kiyono, Soichiro, Kondo, Takayuki, Saito, Tomoko, Nakagawa, Ryo, Suzuki, Eiichiro, Ooka, Yoshihiko, Nakamoto, Shingo, Muroyama, Ryosuke, Tawada, Akinobu, Chiba, Tetsuhiro, Arai, Makoto, Kato, Jun, Ikeda, Jun-ichiro, Takiguchi, Yuichi, Kato, Naoya

“…Background With the evolution of personalized medicine in the field of oncology, which includes optimal treatment selection using next-generation…”
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Baseline soluble MICA levels act as a predictive biomarker for the efficacy of regorafenib treatment in colorectal cancer by Arai, Jun, Otoyama, Yumi, Fujita, Ken-Ichi, Goto, Kaku, Tojo, Masayuki, Katagiri, Atsushi, Nozawa, Hisako, Kubota, Yutaro, Takahashi, Takehiro, Ishida, Hiroo, Tsunoda, Takuya, Matsumoto, Natsumi, Ogawa, Keita, Nakagawa, Ryo, Muroyama, Ryosuke, Kato, Naoya, Yoshida, Hitoshi

“…To evaluate the effect of regorafenib on soluble MHC class I polypeptide-related sequence A (MICA) (sMICA) level in vitro. In addition, we clinically examined…”
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Retinoids Decrease Soluble MICA Concentration by Inhibiting the Enzymatic Activity of ADAM9 and ADAM10 by Otoyama, Yumi, Arai, Jun, Goto, Kaku, Nozawa, Hisako, Nakagawa, Ryo, Muroyama, Ryosuke, Sugiura, Ikuya, Nakajima, Yoko, Kajiwara, Atsushi, Tojo, Masayuki, Ichikawa, Yuki, Uozumi, Shojiro, Shimozuma, Yuu, Uchikoshi, Manabu, Sakaki, Masashi, Kato, Naoya, Yoshida, Hitoshi

“…The association between MHC class I polypeptide-related sequence A (MICA) and hepatocellular carcinoma (HCC) development was identified in our previous…”
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The characteristic changes in hepatitis B virus x region for hepatocellular carcinoma: a comprehensive analysis based on global data by Li, Wenwen, Goto, Kaku, Matsubara, Yasuo, Ito, Sayaka, Muroyama, Ryosuke, Li, Qiang, Kato, Naoya

“…Mutations in hepatitis B virus (HBV) X region (HBx) play important roles in hepatocarcinogenesis while the results remain controversial. We sought to clarify…”
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Alteration of the tumor microenvironment by pharmacological inhibition of EZH2 in hepatocellular carcinoma by Qiang, Na, Ao, Junjie, Nakamura, Masato, Chiba, Tetsuhiro, Kusakabe, Yuko, Kaneko, Tatsuya, Kurosugi, Akane, Kogure, Tadayoshi, Ma, Yaojia, Zhang, Jiaqi, Ogawa, Keita, Kan, Motoyasu, Iwanaga, Terunao, Sakuma, Takafumi, Kanayama, Kengo, Kanzaki, Hiroaki, Kojima, Ryuta, Nakagawa, Ryo, Kondo, Takayuki, Nakamoto, Shingo, Muroyama, Ryosuke, Kato, Jun, Mimura, Naoya, Ma, Anqi, Jin, Jian, Kato, Naoya

“…•Pharmacological inhibition of EZH2 results in increasing MDSCs and attenuating CD8+ T cells in the tumor microenvironment of HCC.•Depletion of MDSCs by…”
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Antiviral Compounds Screening Targeting HBx Protein of the Hepatitis B Virus by Ma, Yaojia, Nakamoto, Shingo, Ao, Junjie, Qiang, Na, Kogure, Tadayoshi, Ogawa, Keita, Nakagawa, Miyuki, Fujiwara, Kisako, Iwanaga, Terunao, Kojima, Ryuta, Kanzaki, Hiroaki, Koroki, Keisuke, Kobayashi, Kazufumi, Kanogawa, Naoya, Kiyono, Soichiro, Nakamura, Masato, Kondo, Takayuki, Nakagawa, Ryo, Ogasawara, Sadahisa, Muroyama, Ryosuke, Chiba, Tetsuhiro, Kato, Jun, Kato, Naoya

“…A functional cure of hepatitis B virus (HBV) infection or HB antigen loss is rarely achieved by nucleos(t)ide analogs which target viral polymerase. HBx…”
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Successful Identification of a Novel Therapeutic Compound for Hepatocellular Carcinoma Through Screening of ADAM9 Inhibitors by Ogawa, Keita, Chiba, Tetsuhiro, Nakamura, Masato, Arai, Jun, Zhang, Jiaqi, Ma, Yaojia, Qiang, N A, Ao, Junjie, Yumita, Sae, Ishino, Takamasa, Kan, Motoyasu, Iwanaga, Terunao, Nakagawa, Miyuki, Fujiwara, Kisako, Sakuma, Takafumi, Kanzaki, Hiroaki, Koroki, Keisuke, Kusakabe, Yuko, Kobayashi, Kazufumi, Kanogawa, Naoya, Kiyono, Soichiro, Kondo, Takayuki, Nakagawa, Ryo, Ogasawara, Sadahisa, Muroyama, Ryosuke, Nakamoto, Shingo, Kanda, Tatsuo, Maruyama, Hitoshi, Kato, Jun, Matsumoto, Shoji, Arai, Takayoshi, Motohashi, Shinichiro, Kato, Naoya

“…MHC-class I-related chain A (MICA) functions as a ligand for natural killer group D, an activating receptor on natural killer (NK) cells, and its expression…”
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Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma by Kumar, Vinod, Yi Lo, Paulisally Hau, Sawai, Hiromi, Kato, Naoya, Takahashi, Atsushi, Deng, Zhenzhong, Urabe, Yuji, Mbarek, Hamdi, Tokunaga, Katsushi, Tanaka, Yasuhito, Sugiyama, Masaya, Mizokami, Masashi, Muroyama, Ryosuke, Tateishi, Ryosuke, Omata, Masao, Koike, Kazuhiko, Tanikawa, Chizu, Kamatani, Naoyuki, Kubo, Michiaki, Nakamura, Yusuke, Matsuda, Koichi

“…MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection and various types of stress. We recently reported that a…”
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Novel chemoimmunotherapeutic strategy for hepatocellular carcinoma based on a genome-wide association study by Goto, Kaku, Annan, Dorcas A., Morita, Tomoko, Li, Wenwen, Muroyama, Ryosuke, Matsubara, Yasuo, Ito, Sayaka, Nakagawa, Ryo, Tanoue, Yasushi, Jinushi, Masahisa, Kato, Naoya

“…Pharmacotherapeutic options are limited for hepatocellular carcinoma (HCC). Recently, we identified the anti-tumor ligand MHC class I polypeptide-related…”
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Characteristic mutations in hepatitis C virus core gene related to the occurrence of hepatocellular carcinoma by Hu, Zhongjie, Muroyama, Ryosuke, Kowatari, Norie, Chang, Jinhai, Omata, Masao, Kato, Naoya

“…Chronic hepatitis C virus (HCV) infection often results in hepatocellular carcinoma (HCC). Previous studies have shown that there might be some characteristic…”
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A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region by Urabe, Yuji, Ochi, Hidenori, Kato, Naoya, Kumar, Vinod, Takahashi, Atsushi, Muroyama, Ryosuke, Hosono, Naoya, Otsuka, Motoyuki, Tateishi, Ryosuke, Lo, Paulisally Hau Yi, Tanikawa, Chizu, Omata, Masao, Koike, Kazuhiko, Miki, Daiki, Abe, Hiromi, Kamatani, Naoyuki, Toyota, Joji, Kumada, Hiromitsu, Kubo, Michiaki, Chayama, Kazuaki, Nakamura, Yusuke, Matsuda, Koichi

“…Background & Aims We performed a genome-wide association study (GWAS) of hepatitis C virus (HCV)-induced liver cirrhosis (LC) to identify predictive biomarkers…”
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