Search Results - "Muro, A F"

New insights into form and function of fibronectin splice variants by White, ES, Baralle, FE, Muro, AF

“…The extracellular matrix (ECM) is a highly dynamic structure that not only provides a physical framework for cells within connective tissues, but also imparts…”
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The fibronectin gene as a model for splicing and transcription studies by Kornblihtt, A R, Pesce, C G, Alonso, C R, Cramer, P, Srebrow, A, Werbajh, S, Muro, A F

“…The fibronectin (FN) gene has become paradigmatic to illustrate genome evolution by exon shuffling, generation of protein diversity by alternative mRNA…”
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Repeated AAV-mediated gene transfer by serotype switching enables long-lasting therapeutic levels of hUgt1a1 enzyme in a mouse model of Crigler–Najjar Syndrome Type I by Bočkor, L, Bortolussi, G, Iaconcig, A, Chiaruttini, G, Tiribelli, C, Giacca, M, Benvenuti, F, Zentilin, L, Muro, A F

“…Adeno-associated virus (AAV) -mediated gene therapy is a promising strategy to treat liver-based monogenic diseases. However, two major obstacles limit its…”
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Impairment of enzymatic antioxidant defenses is associated with bilirubin-induced neuronal cell death in the cerebellum of Ugt1 KO mice by Bortolussi, G, Codarin, E, Antoniali, G, Vascotto, C, Vodret, S, Arena, S, Cesaratto, L, Scaloni, A, Tell, G, Muro, A F

“…Severe hyperbilirubinemia is toxic during central nervous system development. Prolonged and uncontrolled high levels of unconjugated bilirubin lead to…”
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Mild spherocytic hereditary elliptocytosis and altered levels of α- and γ-adducins in β-adducin-deficient mice by MURO, A. F, MARRO, M. L, GAJOVIC, S, PORRO, F, LUZZATTO, L, BARALLE, F. E

“…The membrane skeleton, a dynamic network of proteins associated with the plasma membrane, determines the shape and mechanical properties of erythrocytes…”
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Regulation of the fibronectin EDA exon alternative splicing. Cooperative role of the exonic enhancer element and the 5′ splicing site by Muro, A.F., Iaconcig, A., Baralle, F.E.

“…Alternatively spliced exons generally contain weak splicing sites, and exonic and/or intronic regulatory elements recognised by trans-acting auxiliary splicing…”
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β‐adducin (Add2) KO mice show synaptic plasticity, motor coordination and behavioral deficits accompanied by changes in the expression and phosphorylation levels of the α‐ and γ‐adducin subunits by Porro, F., Rosato‐Siri, M., Leone, E., Costessi, L., Iaconcig, A., Tongiorgi, E., Muro, A. F.

“…Adducins are a family of proteins found in cytoskeleton junctional complexes, which bind and regulate actin filaments and actin‐spectrin complexes. In brain,…”
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Regulated Splicing of the Fibronectin EDA Exon Is Essential for Proper Skin Wound Healing and Normal Lifespan by Muro, Andrés F., Chauhan, Anil K., Gajovic, Srecko, Iaconcig, Alessandra, Porro, Fabiola, Stanta, Giorgio, Baralle, Francisco E.

“…Fibronectins (FNs) are multifunctional high molecular weight glycoproteins present in the blood plasma and in the ECMs of tissues. The FN primary transcript…”
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Interaction of the -170 cyclic AMP response element with the adjacent CCAAT box in the human fibronectin gene promoter by MURO, A. F, BERNATH, V. A, KORNBLIHTT, A. R

“…In the fibronectin gene promoter the cAMP response element (CRE) and the CCAAT box are separated by only 20 base pairs (bp), i.e. two turns of double helix…”
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Coupling of Transcription with Alternative Splicing: RNA Pol II Promoters Modulate SF2/ASF and 9G8 Effects on an Exonic Splicing Enhancer by Cramer, Paula, Cáceres, Javier F, Cazalla, Demián, Kadener, Sebastián, Muro, Andrés F, Baralle, Francisco E, Kornblihtt, Alberto R

“…Alternative mRNA splicing of the fibronectin EDI exon is controlled by a purine-rich exonic splicing enhancer (ESE), postulated as a binding site for SR…”
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Cyclic AMP inhibits fibronectin gene expression in a newly developed granulosa cell line by a mechanism that suppresses cAMP-responsive element-dependent transcriptional activation by Bernath, V A, Muro, A F, Vitullo, A D, Bley, M A, Barañao, J L, Kornblihtt, A R

“…The main role of the ovarian granulosa cells is to nurse the oocyte and to produce estradiol and progesterone upon stimulation by gonadotropins. In fact,…”
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Expression of RGD minus fibronectin that does not form extracellular matrix fibrils is sufficient to decrease tumor metastasis by Urtreger, Alejandro, Porro, Fabiola, Puricelli, Lydia, Werbajh, Santiago, Baralle, Francisco E., Bal de Kier Joffé, Elisa, Kornblihtt, Alberto R., Muro, Andrés F.

“…Fibronectin (FN) is a plasma and extracellular matrix (ECM) glycoprotein, the expression of which may modulate the invasive and metastatic abilities of cancer…”
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Regulation of the human apolipoprotein AIV gene expression in transgenic mice by Baralle, M, Vergnes, L, Muro, A.F, Zakin, M.M, Baralle, F.E, Ochoa, A

“…The apolipoprotein (Apo) AI-CIII-AIV gene cluster has a complex pattern of gene expression that is modulated by both gene- and cluster-specific cis-acting…”
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Regulation of Fibronectin EDA Exon Alternative Splicing: Possible Role of RNA Secondary Structure for Enhancer Display by Muro, Andrés F., Caputi, Massimo, Pariyarath, Rajalakshmi, Pagani, Franco, Buratti, Emanuele, Baralle, Francisco E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter by Srebrow, Anabella, Muro, Andres F., Werbajh, Santiago, Sharp, Phillip A., Kornblihtt, Alberto R.

“…The cAMP response element (CRE) and the CCAAT box of the fibronectin gene promoter are separated by only twenty base pairs. A specific factor that binds the…”
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Alternative splicing of fibronectin: a mouse model demonstrates the identity of in vitro and in vivo systems and the processing autonomy of regulated exons in adult mice by Chauhan, Anil K., Iaconcig, Alessandra, Baralle, Francisco E., Muro, Andrés F.

“…We have designed a novel approach using genetically engineered mice to make a systematic study of the EDA exon regulation of the fibronectin gene during…”
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Impaired motor coordination in mice lacking the EDA exon of the fibronectin gene by Chauhan, Anil Kumar, Moretti, Federico Andrea, Iaconcig, Alessandra, Baralle, Francisco Ernesto, Muro, Andrés Fernando

“…The extracellular matrix (ECM) plays an important role in the central nervous system (CNS) by modulating the migration of cells, axons and dendrites of…”
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Binding of nuclear factors to a satellite DNA of retroviral origin with marked differences in copy number among species of the rodent Ctenomys by Pesce, C. Gustavo, Rossi, Marfa S., Muro, Andrés F., Reig, Osvaldo A., Zorzópulos, Jorge, Komblihtt, Alberto R.

“…The major satellite DNA of the subterranean rodent Ctenomys, named RPCS, contains several consensus sequences characteristic of the U3 region of retroviral…”
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Involvement of fibronectin in the regulation of urokinase production and binding in murine mammary tumor cells by Urtreger, Alejandro J., Aguirre Ghiso, Julio A., Werbajh, Santiago E., Puricelli, Lydia I., Muro, Andrés F., Bal de Kier Joffé, Elisa

“…Tumor invasion and metastasis development is a multistep process involving adhesion molecules as well as tumor proteases. It has been reported that tumor cells…”
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Hypertension in β-Adducin–Deficient Mice by Marro, Martín L, Scremin, Oscar U, Jordan, Maria C, Huynh, Ly, Porro, Fabiola, Roos, Kenneth P, Gajović, Srećko, Baralle, Francisco E, Muro, Andrés F

“…Polymorphic variants of the cytoskeletal protein adducin have been associated with hypertension in humans and rats. However, the direct role of this protein in…”
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