Search Results - "Murnane, John P"

Telomere Loss as a Mechanism for Chromosome Instability in Human Cancer by MURNANE, John P

“…Cancer cells commonly have a high rate of telomere loss, even when expressing telomerase, contributing to chromosome instability and tumor cell progression…”
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DNA-damage response during mitosis induces whole-chromosome missegregation by Bakhoum, Samuel F, Kabeche, Lilian, Murnane, John P, Zaki, Bassem I, Compton, Duane A

“…Many cancers display both structural (s-CIN) and numerical (w-CIN) chromosomal instabilities. Defective chromosome segregation during mitosis has been shown to…”
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The DNA damage response at dysfunctional telomeres, and at interstitial and subtelomeric DNA double-strand breaks by Muraki, Keiko, Murnane, John P.

“…In mammals, DNA double-strand breaks (DSBs) are primarily repaired by classical non-homologous end joining (C-NHEJ), although homologous recombination repair…”
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The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line by Muraki, Keiko, Han, Limei, Miller, Douglas, Murnane, John P

“…Telomeres distinguish chromosome ends from double-strand breaks (DSBs) and prevent chromosome fusion. However, telomeres can also interfere with DNA repair, as…”
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Mechanisms of telomere loss and their consequences for chromosome instability by Muraki, Keiko, Nyhan, Kristine, Han, Limei, Murnane, John P

“…The ends of chromosomes in mammals, called telomeres, are composed of a 6-bp repeat sequence, TTAGGG, which is added on by the enzyme telomerase. In…”
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Numerical chromosomal instability mediates susceptibility to radiation treatment by Bakhoum, Samuel F., Kabeche, Lilian, Wood, Matthew D., Laucius, Christopher D., Qu, Dian, Laughney, Ashley M., Reynolds, Gloria E., Louie, Raymond J., Phillips, Joanna, Chan, Denise A., Zaki, Bassem I., Murnane, John P., Petritsch, Claudia, Compton, Duane A.

“…The exquisite sensitivity of mitotic cancer cells to ionizing radiation (IR) underlies an important rationale for the widely used fractionated radiation…”
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Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks by Muraki, Keiko, Han, Limei, Miller, Douglas, Murnane, John P

“…The caps on the ends of chromosomes, called telomeres, keep the ends of chromosomes from appearing as DNA double-strand breaks (DSBs) and prevent chromosome…”
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Telomeric Double Strand Breaks in G1 Human Cells Facilitate Formation of 5' C-Rich Overhangs and Recruitment of TERRA by Nelson, Christopher B, Alturki, Taghreed M, Luxton, Jared J, Taylor, Lynn E, Maranon, David G, Muraki, Keiko, Murnane, John P, Bailey, Susan M

“…Telomeres, repetitive nucleoprotein complexes that protect chromosomal termini and prevent them from activating inappropriate DNA damage responses (DDRs),…”
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Effect of Telomere Proximity on Telomere Position Effect, Chromosome Healing, and Sensitivity to DNA Double-Strand Breaks in a Human Tumor Cell Line by Kulkarni, Avanti, Zschenker, Oliver, Reynolds, Gloria, Miller, Douglas, Murnane, John. P.

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Differences in the recruitment of DNA repair proteins at subtelomeric and interstitial I-SceI endonuclease-induced DNA double-strand breaks by Alcaraz Silva, Bárbara, Jones, Trevor J., Murnane, John P.

“…•Nonhomologous end-joining protein Ku70 is similar at interstitial and subtelomeric DSBs.•Repair proteins RAD51, BRCA1 and CtIP are greatly increased at…”
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The Loss of a Single Telomere Can Result in Instability of Multiple Chromosomes in a Human Tumor Cell Line by Sabatier, Laure, Ricoul, Michelle, Pottier, Géraldine, Murnane, John P

“…Spontaneous telomere loss has been proposed as an important mechanism for initiating the chromosome instability commonly found in cancer cells. We have…”
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Replication Stress and Telomere Dysfunction Are Present in Cultured Human Embryonic Stem Cells by Janson, Christine, Nyhan, Kristine, Murnane, John P

“…Replication stress causes DNA damage at fragile sites in the genome. DNA damage at telomeres can initiate breakage-fusion-bridge cycles and chromosome…”
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Subtelomeric regions in mammalian cells are deficient in DNA double-strand break repair by Miller, Douglas, Reynolds, Gloria E., Mejia, Ricardo, Stark, Jeremy M., Murnane, John P.

“…We have previously demonstrated that double-strand breaks (DSBs) in regions near telomeres are much more likely to result in large deletions, gross chromosome…”
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Telomere Position Effect and Silencing of Transgenes near Telomeres in the Mouse by Pedram, Mehrdad, Sprung, Carl N., Gao, Qing, Lo, Anthony W. I., Reynolds, Gloria E., Murnane, John P.

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Telomere dysfunction and chromosome instability by Murnane, John P

“…The ends of chromosomes are composed of a short repeat sequence and associated proteins that together form a cap, called a telomere, that keeps the ends from…”
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Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell line by Zschenker, Oliver, Kulkarni, Avanti, Miller, Douglas, Reynolds, Gloria. E., Granger-Locatelli, Marine, Pottier, Géraldine, Sabatier, Laure, Murnane, John. P.

“…We previously reported that a single DNA double-strand break (DSB) near a telomere in mouse embryonic stem cells can result in chromosome instability. We have…”
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Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein by BAI, Yongli, MURNANE, John P

“…Werner Syndrome (WS) is an autosomal recessive disease characterized by premature aging and chromosome instability. The protein involved in WS, WRN, is a…”
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PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells by Reynolds, Gloria E., Gao, Qing, Miller, Douglas, Snow, Bryan E., Harrington, Lea A., Murnane, John. P.

“…Telomerase serves to maintain telomeric repeat sequences at the ends of chromosomes. However, telomerase can also add telomeric repeat sequences at DNA…”
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Telomeres and chromosome instability by Murnane, John P.

“…Genomic instability has been proposed to play an important role in cancer by accelerating the accumulation of genetic changes responsible for cancer cell…”
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Chromosome Instability as a Result of Double-Strand Breaks near Telomeres in Mouse Embryonic Stem Cells by Lo, Anthony W. I., Sprung, Carl N., Fouladi, Bijan, Pedram, Mehrdad, Sabatier, Laure, Ricoul, Michelle, Reynolds, Gloria E., Murnane, John P.

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