Search Results - "Murnane, J M"
-
1
Alterations in cathepsin H activity and protein patterns in human colorectal carcinomas
Published in British journal of cancer (01-04-2000)“…Our analyses of cathepsin H activity levels and protein forms in human colorectal cancers compared to matched control mucosa support the concept that altered…”
Get full text
Journal Article -
2
Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas
Published in International journal of cancer (21-08-1998)“…The metastatic potential of ras‐transfected cells has been attributed in part to significant ras induction of proteinase expression. To determine whether…”
Get full text
Journal Article -
3
Marked increases in cathepsin B and L activities distinguish papillary carcinoma of the thyroid from normal thyroid or thyroid with non‐neoplastic disease
Published in International journal of cancer (16-05-1996)“…Cathepsin B (CB) and cathepsin L (CL) are cysteine endopeptidases involved in the processing of thyroglobulin (Tg) in the normal thyroid. As thyroglobulin…”
Get full text
Journal Article -
4
Stage-specific increases in cathepsin B messenger RNA content in human colorectal carcinoma
Published in Cancer research (Chicago, Ill.) (15-02-1991)“…Cathepsin B mRNA levels and banding patterns were characterized in human colorectal mucosa and carcinoma tissues from patients with tumors of different Dukes'…”
Get full text
Journal Article -
5
Cysteine protease activities and tumor development in human colorectal carcinoma
Published in Cancer research (Chicago, Ill.) (15-07-1989)“…Many studies of malignant cells or tissues in culture have implicated cysteine proteases in the progression of malignancy. We have extended these observations…”
Get full text
Journal Article -
6
Cysteine endopeptidase activity levels in normal human tissues, colorectal adenomas and carcinomas
Published in International journal of cancer (30-09-1991)“…We have assayed cysteine endopeptidase activities in 17 types of normal human tissue and in matched sets of colorectal mucosa, adenoma and carcinoma samples…”
Get more information
Journal Article -
7
Cathepsin B activity and protein levels in thyroid carcinoma, Graves' disease, and multinodular goiters
Published in Thyroid (New York, N.Y.) (01-06-1999)“…Cathepsin B (CB) is involved in the hydrolysis of thyroglobulin (Tg) and thought to be regulated by thyroid stimulating hormone (TSH) in the normal thyroid…”
Get more information
Journal Article -
8
N‐ras protein: Frequent quantitative and qualitative changes occur in human colorectal carcinomas
Published in International journal of cancer (29-05-1997)“…Point mutation and overexpression are recognized mechanisms for ras activation in malignancy. However, little information is available on overexpression of…”
Get full text
Journal Article -
9
Embryonic--Fetal Erythroid Characteristics of a Human Leukemic Cell Line
Published in Proceedings of the National Academy of Sciences - PNAS (01-06-1980)“…We have studied a number of cell surface, enzyme, and protein markers in the human leukemic K562 cell line. We have confirmed previous observations that these…”
Get full text
Journal Article -
10
Human cathepsin B-encoding cDNAs: sequence variations in the 3'-untranslated region
Published in Gene (25-02-1994)“…We have isolated two cathepsin B (CTSB)-encoding cDNAs, hCBF1 and hCBF2, from a normal human embryonic fibroblast library. These clones demonstrate 98%…”
Get more information
Journal Article -
11
Expression and induction of cathepsins B and D in K562 cells
Published in Experimental hematology (01-01-1988)“…Three distinct lysosomal protease activities have been identified in the human leukemia cell line, K562. These include cathepsin D, the classic protease of the…”
Get more information
Journal Article -
12
Chloride transport properties of human leukemic cell lines K562 and HL60
Published in The American journal of physiology (01-07-1984)“…The Cl- transport characteristics of the human leukemic cell lines K562 and HL60, with erythroid and granulocytic phenotypic features, respectively, were…”
Get full text
Journal Article -
13
Studies of BFU-E in flask cultures of human peripheral and cord blood cells
Published in Proceedings of the Society for Experimental Biology and Medicine (01-11-1983)“…Early erythroid progenitors (the burst-forming units-erythroid or BFU-E) from human peripheral and cord blood mononuclear cells were maintained in flask…”
Get more information
Journal Article -
14
Glucoprivic feeding is impaired by lateral or fourth ventricular alloxan injection
Published in The American journal of physiology (01-09-1982)“…Feeding and blood glucose responses to insulin and 2-deoxy-D-glucose (2-DG) were examined in rats previously given lateral or fourth ventricular injections of…”
Get full text
Journal Article -
15
Tay-Sachs' and Sandhoff's Diseases: The Assignment of Genes for Hexosaminidase A and B to Individual Human Chromosomes
Published in Proceedings of the National Academy of Sciences - PNAS (01-01-1975)“…The techniques of somatic cell genetics have been used to establish the linkage relationships of loci coding for two forms (A and B) of hexosaminidase (EC…”
Get full text
Journal Article -
16
Intraventricular alloxan impairs feeding to both central and systemic glucoprivation
Published in Physiology & behavior (01-04-1985)“…Fourth ventricular alloxan injections impair the feeding response to systemically induced glucoprivation. However, the effect of alloxan on responses to…”
Get more information
Journal Article -
17
Elevations in Cathepsin B Protein Content and Enzyme Activity Occur Independently of Glycosylation during Colorectal Tumor Progression
Published in The Journal of biological chemistry (14-11-1997)“…Western blots, enzyme assays, protein glycosylation studies, and immunohistochemical staining were used to characterize cathepsin B expression at successive…”
Get full text
Journal Article -
18
Hemin Control of Heme Biosynthesis and Catabolism in a Human Leukemia Cell Line
Published in Blood (01-09-1980)“…Hemin treatment of the Philadelphia chromosome positive leukemia cell line, K562, accentuates a number of erythroid phenotypic characteristics. The nature of…”
Get full text
Journal Article -
19
Alloxan-induced glucoprivic feeding deficits are blocked by D-glucose and amygdalin
Published in Pharmacology, biochemistry and behavior (01-01-1985)“…Intracerebroventricular injection of alloxan, a pancreatic beta (B) cell cytotoxin, impairs glucoprivic feeding in rats. The goal of this experiment was to…”
Get more information
Journal Article -
20
Induction of Erythropoietic Colonies in a Human Chronic Myelogenous Leukemia Cell Line
Published in Blood (01-11-1979)“…The ability of cells derived from the K562 cell line to generate erythropoietic colonies was studied. The K562 cell line was derived from a patient with…”
Get full text
Journal Article