Search Results - "Murley, Alexander G"

Neurochemistry-enriched dynamic causal models of magnetoencephalography, using magnetic resonance spectroscopy by Jafarian, Amirhossein, Hughes, Laura E, Adams, Natalie E, Lanskey, Juliette H, Naessens, Michelle, Rouse, Matthew A, Murley, Alexander G, Friston, Karl J, Rowe, James B

“…•We developed neurochemistry-enriched dynamic causal model of resting-state MEG data using MRS measurements of neurotransmitter…”
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Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes by Hezemans, Frank H, Wolpe, Noham, O'Callaghan, Claire, Ye, Rong, Rua, Catarina, Jones, P Simon, Murley, Alexander G, Holland, Negin, Regenthal, Ralf, Tsvetanov, Kamen A, Barker, Roger A, Williams-Gray, Caroline H, Robbins, Trevor W, Passamonti, Luca, Rowe, James B

“…Apathy is a debilitating feature of many neuropsychiatric diseases, that is typically described as a reduction of goal-directed behaviour. Despite its…”
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Syndromes associated with frontotemporal lobar degeneration change response patterns on visual analogue scales by Williams, Rebecca S., Adams, Natalie E., Hughes, Laura E., Rouse, Matthew A., Murley, Alexander G., Naessens, Michelle, Street, Duncan, Holland, Negin, Rowe, James B.

“…Self-report scales are widely used in cognitive neuroscience and psychology. However, they rest on the central assumption that respondents engage meaningfully…”
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Characterizing cerebral metabolite profiles in anorexia and bulimia nervosa and their associations with habitual behavior by Westwater, Margaret L., Murley, Alexander G., Diederen, Kelly M. J., Carpenter, T. Adrian, Ziauddeen, Hisham, Fletcher, Paul C.

“…Anorexia nervosa (AN) and bulimia nervosa (BN) are associated with altered brain structure and function, as well as increased habitual behavior. This…”
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Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity by Kaalund, Sanne Simone, Passamonti, Luca, Allinson, Kieren S J, Murley, Alexander G, Robbins, Trevor W, Spillantini, Maria Grazia, Rowe, James B

“…The locus coeruleus is the major source of noradrenaline to the brain and contributes to a wide range of physiological and cognitive functions including…”
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Frontotemporal lobar degeneration changes neuronal beta-frequency dynamics during the mismatch negativity response by Perry, Alistair, Hughes, Laura E., Adams, Natalie E., Naessens, Michelle, Kloosterman, Niels A., Rouse, Matthew A., Murley, Alexander G., Street, Duncan, Jones, P. Simon, Rowe, James B.

“…•We confirmed a unique role for the R IFG during the roving oddball paradigm.•R IFG showed increased beta1 power change to unexpected deviant…”
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The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration by Perry, Alistair, Hughes, Laura E., Adams, Natalie, Naessens, Michelle, Murley, Alexander G., Rouse, Matthew A., Street, Duncan, Jones, P. Simon, Cope, Thomas E., Kocagoncu, Ece, Rowe, James B.

“…There is a pressing need to accelerate therapeutic strategies against the syndromes caused by frontotemporal lobar degeneration, including symptomatic…”
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7T MRI detects widespread brain iron deposition in neuroferritinopathy by Murley, Alexander G., Rua, Catarina, Biggs, Heather, Rodgers, Christopher T., Matys, Tomasz, Ameele, Jelle, Horvath, Rita, Chinnery, Patrick F.

“…Neuroferritinopathy is a disorder of neurodegeneration with brain iron accumulation that has no proven disease‐modifying treatments. Clinical trials require…”
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Neurotransmitter deficits from frontotemporal lobar degeneration by Murley, Alexander G, Rowe, James B

“…Murley and Rowe review the neurochemical changes arising from frontotemporal lobar degeneration, including the syndromes frontotemporal dementia, progressive…”
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Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes by Murley, Alexander G, Coyle-Gilchrist, Ian, Rouse, Matthew A, Jones, P Simon, Li, Win, Wiggins, Julie, Lansdall, Claire, Rodríguez, Patricia Vázquez, Wilcox, Alicia, Tsvetanov, Kamen A, Patterson, Karalyn, Lambon Ralph, Matthew A, Rowe, James B

“…The syndromes caused by frontotemporal lobar degeneration have highly heterogeneous and overlapping clinical features. There has been great progress in the…”
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Reduced Glutamate Turnover in the Putamen Is Linked With Automatic Habits in Human Cocaine Addiction by Ersche, Karen D., Lim, Tsen Vei, Murley, Alexander G., Rua, Catarina, Vaghi, Matilde M., White, Tara L., Williams, Guy B., Robbins, Trevor W.

“…The balance between goal-directed behavior and habits has been hypothesized to be biased toward the latter in individuals with cocaine use disorder (CUD),…”
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Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson's disease by O'Callaghan, Claire, Hezemans, Frank H, Ye, Rong, Rua, Catarina, Jones, P Simon, Murley, Alexander G, Holland, Negin, Regenthal, Ralf, Tsvetanov, Kamen A, Wolpe, Noham, Barker, Roger A, Williams-Gray, Caroline H, Robbins, Trevor W, Passamonti, Luca, Rowe, James B

“…Cognitive decline is a common feature of Parkinson's disease, and many of these cognitive deficits fail to respond to dopaminergic therapy. Therefore,…”
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GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition by Murley, Alexander G, Rouse, Matthew A, Jones, P Simon, Ye, Rong, Hezemans, Frank H, O'Callaghan, Claire, Frangou, Polytimi, Kourtzi, Zoe, Rua, Catarina, Carpenter, T Adrian, Rodgers, Christopher T, Rowe, James B

“…Behavioural disinhibition is a common feature of the syndromes associated with frontotemporal lobar degeneration (FTLD). It is associated with high morbidity…”
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GABAergic cortical network physiology in frontotemporal lobar degeneration by Adams, Natalie E, Hughes, Laura E, Rouse, Matthew A, Phillips, Holly N, Shaw, Alexander D, Murley, Alexander G, Cope, Thomas E, Bevan-Jones, W Richard, Passamonti, Luca, Street, Duncan, Holland, Negin, Nesbitt, David, Friston, Karl, Rowe, James B

“…The clinical syndromes caused by frontotemporal lobar degeneration are heterogeneous, including the behavioural variant frontotemporal dementia (bvFTD) and…”
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Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes by Murley, Alexander G., Tsvetanov, Kamen A., Rouse, Matthew A., Jones, P. Simon, Sværke, Katrine, Li, Win, Carpenter, Adrian, Rowe, James B.

“…•We report MR-spectroscopy in syndromes linked to frontotemporal lobar degeneration (FTLD).•NAA and glutamate concentrations in the frontal lobe are reduced by…”
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Peripheral innate immunophenotype in neurodegenerative disease: blood-based profiles and links to survival by Strauss, Alexandra, Swann, Peter, Kigar, Stacey L, Christou, Rafailia, Savinykh Yarkoni, Natalia, Turner, Lorinda, Murley, Alexander G, Chouliaras, Leonidas, Shapiro, Noah, Ashton, Nicholas J, Savulich, George, Bevan-Jones, W Richard, Surendranthan, Ajenthan, Blennow, Kaj, Zetterberg, Henrik, O'Brien, John T, Rowe, James B, Malpetti, Maura

“…The innate immune system plays an integral role in the progression of many neurodegenerative diseases. In addition to central innate immune cells (e.g.,…”
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Locus Coeruleus Integrity Is Linked to Response Inhibition Deficits in Parkinson's Disease and Progressive Supranuclear Palsy by Ye, Rong, Hezemans, Frank H, O'Callaghan, Claire, Tsvetanov, Kamen A, Rua, Catarina, Jones, P Simon, Holland, Negin, Malpetti, Maura, Murley, Alexander G, Barker, Roger A, Williams-Gray, Caroline H, Robbins, Trevor W, Passamonti, Luca, Rowe, James B

“…Parkinson's disease (PD) and progressive supranuclear palsy (PSP) both impair response inhibition, exacerbating impulsivity. Inhibitory control deficits vary…”
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Predicting loss of independence and mortality in frontotemporal lobar degeneration syndromes by Murley, Alexander G, Rouse, Matthew A, Coyle-Gilchrist, Ian T S, Jones, P Simon, Li, Win, Wiggins, Julie, Lansdall, Claire, Vázquez Rodríguez, Patricia, Wilcox, Alicia, Patterson, Karalyn, Rowe, James B

“…ObjectiveTo test the hypothesis that in syndromes associated with frontotemporal lobar degeneration, behavioural impairment predicts loss of functional…”
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GABA-ergic Dynamics in Human Frontotemporal Networks Confirmed by Pharmaco-Magnetoencephalography by Adams, Natalie E, Hughes, Laura E, Phillips, Holly N, Shaw, Alexander D, Murley, Alexander G, Nesbitt, David, Cope, Thomas E, Bevan-Jones, W Richard, Passamonti, Luca, Rowe, James B

“…To bridge the gap between preclinical cellular models of disease and imaging of human cognitive network dynamics, there is a pressing need for informative…”
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Neurophysiological consequences of synapse loss in progressive supranuclear palsy by Adams, Natalie E, Jafarian, Amirhossein, Perry, Alistair, Rouse, Matthew A, Shaw, Alexander D, Murley, Alexander G, Cope, Thomas E, Bevan-Jones, W Richard, Passamonti, Luca, Street, Duncan, Holland, Negin, Nesbitt, David, Hughes, Laura E, Friston, Karl J, Rowe, James B

“…Abstract Synaptic loss occurs early in many neurodegenerative diseases and contributes to cognitive impairment even in the absence of gross atrophy. Currently,…”
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