Modulation of rat serum lipid profile and nephrotic indices following oral exposure to the extracts of chilli pepper

Modulation of rat serum lipid profile and nephrotic indices following oral exposure to the extracts of chilli pepper

Background: The increasing application of plants for medicinal purposes necessitates safety/toxicity profiling. Objective: In the present study, we evaluated the toxicological effects of the ethanolic extracts of the leaves (CAL), root (CAR) and stem (CAS) of Capsicum annuum in rats. Methods: Male W...

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Published in:Eurasian journal of biosciences Vol. 13; no. 2; pp. 2321 - 2326
Main Authors: Sulaiman, F A, Yusuf, B O, Omar, S A, Muritala, H T, Adisa, M J, Olopade, A A, Babajamu, F I, Jimba, A T, Babatunde, A L, Adeniyi, B A, Opaleye, B R, Maimako, R F, Otohinoyi, D A, Bello, O K, Rotimi, D, Olaolu, T D, Nwonuma, C O, Alejolowo, O O, Batiha, G E, Osemwegie, O O, Adeyemi, O S
Format: Journal Article
Language:English
Published: Izmir Foundation for Environmental Protection and Research, Çevre Koruma ve Araştırma Vakfı (ÇEVKOR) 01-01-2019
Subjects:
Albumin
Bilirubin
Biochemistry
Capsicum annuum
Creatinine
Fruits
Heart
Hepatotoxicity
Herbal medicine
Laboratory animals
Liver
Medicinal plants
Oral administration
Phosphatase
Plant extracts
Rodents
Toxicity
Tropical diseases
Urea
Variance analysis
United Kingdom > UK
Nigeria
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Summary:Background: The increasing application of plants for medicinal purposes necessitates safety/toxicity profiling. Objective: In the present study, we evaluated the toxicological effects of the ethanolic extracts of the leaves (CAL), root (CAR) and stem (CAS) of Capsicum annuum in rats. Methods: Male Wistar rats were randomly assigned groups and given oral administration of the extracts or distilled water for 28 days. Results: Data showed that administration of ethanolic extracts of CAL, CAR and CAS did alter the liver function indices but not in a clear-cut manner to suggest hepatotoxicity. The CAR and CAS extracts decreased (p<0.05) the rat serum albumin levels compared with the control. In contrast, CAL extracts raised (p<0.05) the rat serum albumin level relative to the control. The plant extract administration raised rat serum bilirubin level compared with the control. Further, the extracts caused reduction (p<0.05) in rat serum TAG levels compared with the control. The CAL, CAR and CAS extracts did not significantly affect the rat serum creatinine level, but caused significant elevation of rat serum urea compared with the control. Conclusion: Taken together, findings do not only support the cardio-protective potential of C. annuum extracts, but implicate the nephrotoxic tendency of the plant extracts.
ISSN:1307-9867