Search Results - "Murillo, Miguel M."

Requirement for Interaction of PI3-Kinase p110α with RAS in Lung Tumor Maintenance by Castellano, Esther, Sheridan, Clare, Thin, May Zaw, Nye, Emma, Spencer-Dene, Bradley, Diefenbacher, Markus E., Moore, Christopher, Kumar, Madhu S., Murillo, Miguel M., Grönroos, Eva, Lassailly, Francois, Stamp, Gordon, Downward, Julian

“…RAS proteins directly activate PI3-kinases. Mice bearing a germline mutation in the RAS binding domain of the p110α subunit of PI3-kinse are resistant to the…”
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Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer by Murillo, Miguel M., Rana, Sareena, Spencer-Dene, Bradley, Nye, Emma, Stamp, Gordon, Downward, Julian

“…RAS family GTPases contribute directly to the regulation of type I phosphoinositide 3-kinases (PI3Ks) via RAS-binding domains in the PI3K catalytic p110…”
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Loss of the Tumor Suppressor Gene NF2, Encoding Merlin, Constitutively Activates Integrin-Dependent mTORC1 Signaling by López-Lago, Miguel A., Okada, Tomoyo, Murillo, Miguel M., Socci, Nick, Giancotti, Filippo G.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Involvement of EGF receptor and c-Src in the survival signals induced by TGF-β1 in hepatocytes by MURILLO, Miguel M, DEL CASTILLO, Gaelle, SANCHEZ, Aranzazu, FERNANDEZ, Margarita, FABREGAT, Isabel

“…Transforming growth factor beta1 (TGF-β1) belongs to a family of polypeptide factors, whose cytostatic and apoptotic functions help restrain the growth of…”
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Snail1 suppresses TGF-β-induced apoptosis and is sufficient to trigger EMT in hepatocytes by Franco, D. Lorena, Mainez, Jèssica, Vega, Sonia, Sancho, Patricia, Murillo, Miguel M, de Frutos, Cristina A, del Castillo, Gaelle, López-Blau, Cristina, Fabregat, Isabel, Nieto, M. Angela

“…Although TGF-β suppresses early stages of tumour development, it later contributes to tumour progression when cells become resistant to its suppressive…”
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The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-β-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms by Sancho, Patricia, Bertran, Esther, Caja, Laia, Carmona-Cuenca, Irene, Murillo, Miguel M., Fabregat, Isabel

“…Transforming growth factor-beta (TGF-β) induces apoptosis in hepatocytes, through a mechanism mediated by reactive oxygen species (ROS) production. Numerous…”
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Role of CXCR4/SDF-1α in the migratory phenotype of hepatoma cells that have undergone epithelial–mesenchymal transition in response to the transforming growth factor-β by Bertran, Esther, Caja, Laia, Navarro, Estanis, Sancho, Patricia, Mainez, Jèssica, Murillo, Miguel M., Vinyals, Antonia, Fabra, Àngels, Fabregat, Isabel

“…Treatment of FaO rat hepatoma cells with TGF-β selects cells that survive to its apoptotic effect and undergo epithelial–mesenchymal transitions (EMT). We have…”
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RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance by Lionarons, Daniël A., Hancock, David C., Rana, Sareena, East, Philip, Moore, Christopher, Murillo, Miguel M., Carvalho, Joana, Spencer-Dene, Bradley, Herbert, Eleanor, Stamp, Gordon, Damry, Djamil, Calado, Dinis P., Rosewell, Ian, Fritsch, Ralph, Neubig, Richard R., Molina-Arcas, Miriam, Downward, Julian

“…RAC1 P29 is the third most commonly mutated codon in human cutaneous melanoma, after BRAF V600 and NRAS Q61. Here, we study the role of RAC1P29S in melanoma…”
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Activation of NADPH oxidase by transforming growth factor-β in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-κB-dependent mechanism by Murillo, Miguel M., Carmona-Cuenca, Irene, del Castillo, Gaelle, Ortiz, Conrad, Roncero, César, Sánchez, Aránzazu, Fernández, Margarita, Fabregat, Isabel

“…The TGF-β (transforming growth factor-β) induces survival signals in foetal rat hepatocytes through transactivation of EGFR (epidermal growth factor receptor)…”
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Autocrine production of TGF-β confers resistance to apoptosis after an epithelial–mesenchymal transition process in hepatocytes: Role of EGF receptor ligands by del Castillo, Gaelle, Murillo, Miguel M., Álvarez-Barrientos, Alberto, Bertran, Esther, Fernández, Margarita, Sánchez, Aránzazu, Fabregat, Isabel

“…Transforming growth factor-beta (TGF-β) induces apoptosis in fetal rat hepatocytes. However, a subpopulation of these cells survives, concomitant with changes…”
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Differential intracellular signalling induced by TGF-β in rat adult hepatocytes and hepatoma cells: Implications in liver carcinogenesis by Caja, Laia, Ortiz, Conrad, Bertran, Esther, Murillo, Miguel M., Miró-Obradors, M. Jesús, Palacios, Evangelina, Fabregat, Isabel

“…The transforming growth factor-beta (TGF-β) regulates hepatocyte growth, inhibiting proliferation and inducing apoptosis. Indeed, escaping from the…”
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Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-β in fetal rat hepatocytes by Herrera, Blanca, Murillo, Miguel M, Álvarez-Barrientos, Alberto, Beltrán, Jesús, Fernández, Margarita, Fabregat, Isabel

“…Transforming growth factor-β (TGF-β) induces an oxidative stress process in hepatocytes that mediates its apoptotic activity. To determine the cellular source…”
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Transforming growth factor-beta activates both pro-apoptotic and survival signals in fetal rat hepatocytes by Valdés, Francisco, Murillo, Miguel M, Valverde, Ángela M, Herrera, Blanca, Sánchez, Aránzazu, Benito, Manuel, Fernández, Margarita, Fabregat, Isabel

“…Transforming growth factor-beta (TGF-β) induces apoptosis in fetal rat hepatocytes. However, a subpopulation of these cells survives concomitant with changes…”
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TGF-beta dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells by Proell, Verena, Carmona-Cuenca, Irene, Murillo, Miguel M, Huber, Heidemarie, Fabregat, Isabel, Mikulits, Wolfgang

“…The activation of hepatic stellate cells (HSCs) plays a pivotal role during liver injury because the resulting myofibroblasts (MFBs) are mainly responsible for…”
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Autocrine production of TGF-[beta] confers resistance to apoptosis after an epithelial-mesenchymal transition process in hepatocytes: Role of EGF receptor ligands by Gaelle del Castillo, Murillo, Miguel M, Álvarez-Barrientos, Alberto, Bertran, Esther, Fernández, Margarita, Sánchez, Aránzazu, Fabregat, Isabel

“…Transforming growth factor-beta (TGF-[beta]) induces apoptosis in fetal rat hepatocytes. However, a subpopulation of these cells survives, concomitant with…”
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Abstract A169: The role of the RAS-PI3K interaction in tumor maintenance and metastasis by Murillo, Miguel M., Tilley, Frances, Lassailly, Francois, Downward, Julian

“…Abstract RAS is the most frequently activated dominant oncogene in human cancer. The importance of the RAS-PI3K connection in physiological and pathological…”
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RAC1 P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance by Lionarons, Daniël A, Hancock, David C, Rana, Sareena, East, Philip, Moore, Christopher, Murillo, Miguel M, Carvalho, Joana, Spencer-Dene, Bradley, Herbert, Eleanor, Stamp, Gordon, Damry, Djamil, Calado, Dinis P, Rosewell, Ian, Fritsch, Ralph, Neubig, Richard R, Molina-Arcas, Miriam, Downward, Julian

“…RAC1 P29 is the third most commonly mutated codon in human cutaneous melanoma, after BRAF V600 and NRAS Q61. Here, we study the role of RAC1 in melanoma…”
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Role of CXCR4/SDF-1a in the migratory phenotype of hepatoma cells that have undergone epithelial- mesenchymal transition in response to the transforming growth factor-b by Bertran, Esther, Caja, Laia, Navarro, Estanis, Sancho, Patricia, Mainez, Jessica, Murillo, Miguel M, Vinyals, Antonia, Fabra, Angels, Fabregat, Isabel

“…Treatment of FaO rat hepatoma cells with TGF-b selects cells that survive to its apoptotic effect and undergo epithelial-mesenchymal transitions (EMT). We have…”
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Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nucler factor-kappa B-dependent mechanism by Murillo, Miguel M, Carmona-Cuenca, Irene, del Castillo, Gaelle, Ortiz, Conrad, Roncero, César, Sánchez, Aránzazu, Fernández, Margarita, Fabregat, Isabel

“…The transforming growth factor-beta (TGF-β) induces survival signals in foetal rat hepatocytes through transactivation of the epidermal growth factor receptor…”
Get full text

Involvement of EGF receptor and c-Src in the survival signals induced by TGF-beta1 in hepatocytes by Murillo, Miguel M, del Castillo, Gaelle, Sánchez, Aránzazu, Fernández, Margarita, Fabregat, Isabel

“…Transforming growth factor beta1 (TGF-beta1) belongs to a family of polypeptide factors, whose cytostatic and apoptotic functions help restrain the growth of…”
Get full text