Search Results - "Murgolo, N J"

X-Ray Structure of Trypanothione Reductase from Crithidia fasciculata at 2.4-Å Resolution by Kuriyan, John, Kong, Xiang-Peng, Krishna, T. S. R., Sweet, Robert M., Murgolo, Nicholas J., Field, Helen, Cerami, Anthony, Henderson, Graeme B.

“…Trypanosomes and related protozoan parasites lack glutathione reductase and possess instead a closely related enzyme that serves as the reductant of a…”
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Engineering the Substrate Specificity of Glutathione Reductase Toward that of Trypanothione Reduction by Henderson, Graeme B., Murgolo, Nicholas J., Kuriyan, John, Osapay, Klara, Kominos, Dorothea, Berry, Alan, Scrutton, Nigel S., Hinchliffe, Nigel W., Perham, Richard N., Cerami, Anthony

“…Glutathione reductase (EC 1.6.4.2; CAS registry number 9001-48-3) and trypanothione reductase (CAS registry number 102210-35-5), which are related flavoprotein…”
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The neurokinin-1 and neurokinin-2 receptor binding sites of MDL103,392 differ by GREENFEDER, S, CHEEWATRAKOOLPONG, B, BILLAH, M, EGAN, R. W, KEENE, E, MURGOLO, N. J, ANTHES, J. C

“…Several small molecule non-peptide antagonists of the NK-1 and NK-2 receptors have been developed. Mutational analysis of the receptor protein sequence has led…”
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Pulmonary Biology Of Anti-interleukin 5 Antibodies by Egan, R.W, Athwahl, D, Chou, C-C, Chapman, R.W, Emtage, S, Jenh, C-H, Kung, T.T, Mauser, P.J, Murgolo, N.J, Bodmer, M.W

“…Interleukin 5 (IL-5) is a critical cytokine for the maturation of eosinophil precursors to eosinophils in the bone marrow and those eosinophils then accumulate…”
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A homology model of human interferon alpha-2 by Murgolo, N J, Windsor, W T, Hruza, A, Reichert, P, Tsarbopoulos, A, Baldwin, S, Huang, E, Pramanik, B, Ealick, S, Trotta, P P

“…An atomic coordinate five alpha-helix three-dimensional model is presented for human interferon alpha-2 (HuIFN alpha 2). The HuIFN alpha 2 structure was…”
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The Differential Sensitivity of Human and Rhesus Macaque CCR5 to Small-Molecule Inhibitors of Human Immunodeficiency Virus Type 1 Entry Is Explained by a Single Amino Acid Difference and Suggests a Mechanism of Action for These Inhibitors by BILLICK, Erika, SEIBERT, Christoph, SAKMAR, Thomas P, MOORE, John P, KUHMANN, Shawn E, PUGACH, Pavel, KETAS, Tom, TRKOLA, Alexandra, ENDRES, Michael J, MURGOLO, Nicholas J, COATES, Elizabeth, REYES, Gregory R, BAROUDY, Bahige M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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EmtA, a rRNA methyltransferase conferring high‐level evernimicin resistance by Mann, Paul A., Xiong, Liqun, Mankin, Alexander S., Chau, Andrew S., Mendrick, Cara A., Najarian, David J., Cramer, Christina A., Loebenberg, David, Coates, Elizabeth, Murgolo, Nicholas J., Aarestrup, Frank M., Goering, Richard V., Black, Todd A., Hare, Roberta S., McNicholas, Paul M.

“…Enterococcus faecium strain 9631355 was isolated from animal sources on the basis of its resistance to the growth promotant avilamycin. The strain also…”
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Structural and Biological Stability of the Human Interleukin 10 Homodimer by Syto, Rosalinda, Murgolo, Nicholas J, Braswell, Emory H, Mui, Philip, Huang, Eric, Windsor, William T

“…Human interleukin 10 (huIL-10) is a cytokine that regulates the synthesis of type 1 helper T cell derived cytokines such as γ-interferon, interleukin 2, and…”
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Mapping and characterization of the epitope(s) of Sch 55700, a humanized mAb, that inhibits human IL-5 by Zhang, Ji, Kuvelkar, Reshma, Murgolo, Nicholas J., Taremi, S. Shane, Chou, Chuan-Chu, Wang, Peng, Billah, Motasim M., Egan, Robert W.

“…mAb against human IL-5 inhibit pulmonary eosinophilia, tissue damage and airway hyper-reactivity in allergic animal models. Sch 55700 is a humanized,…”
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Inhibition of pulmonary eosinophilia and hyperreactivity by antibodies to interleukin-5 by Egan, R W, Athwahl, D, Chou, C C, Emtage, S, Jehn, C H, Kung, T T, Mauser, P J, Murgolo, N J, Bodmer, M W

“…Eosinophils infiltrate into the lungs during asthma and may cause the damage associated with pulmonary inflammation. In allergic animal models, antibodies to…”
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Two related neurokinin-1 receptor antagonists have overlapping but different binding sites by Greenfeder, Scott, Cheewatrakoolpong, Boonlert, Anthes, John, Billah, Motasim, Egan, Robert W, Brown, Joan E, Murgolo, Nicholas J

“…The neuropeptide substance P binds to the G protein-coupled neurokinin-1 (NK-1) receptor and elicits cellular responses thought to be involved in pain,…”
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Presenilin mutations in Alzheimer's disease: molecular models suggest a potential functional locus by Murgolo, Nicholas J., Brown, Joan E., Bayne, Marvin L., Strader, Catherine D.

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The three-dimensional solution structure of the SRC homology domain-2 of the growth factor receptor-bound protein-2 by Senior, M M, Frederick, A F, Black, S, Murgolo, N J, Perkins, L M, Wilson, O, Snow, M E, Wang, Y S

“…A set of high-resolution three-dimensional solution structures of the Src homology region-2 (SH2) domain of the growth factor receptor-bound protein-2 was…”
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Structure and humanization of a rat monoclonal Fab to human interleukin-5 by Cook, William J., Walter, Leigh J., Murgolo, Nicholas J., Chou, Chuan-Chu, Petro, Mary, Zavodny, Paul J., Narula, Satwant K., Ramanathan, Lata, Trotta, Paul P., Nagabhushan, Tattanahalli L.

“…The X-ray crystal structure of a rat monoclonal Fab JES1-39D10, raised against recombinant human interleukin-5, has been determined with the use of molecular…”
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Crystallization and preliminary X-ray investigation of recombinant human interleukin 10 by Cook, W J, Windsor, W T, Murgolo, N J, Tindall, S H, Nagabhushan, T L, Walter, M R

“…Crystals of recombinant human interleukin 10 have been grown from solutions of ammonium sulfate. The crystals are tetragonal, space group P4(1)2(1)2 or…”
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The conformation of dolichol by Murgolo, Nicholas J, Patel, Akhileswar, Stivala, Salvatore S, Wong, Tommy K

“…An understanding of the natural conformation of dolichol is important for the elucidation of the mechanism of protein glycosylation and dolichol's other as yet…”
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P518/Qrfp sequence polymorphisms in SAMP6 osteopenic mouse by Zhang, Qing, Qiu, Ping, Arreaza, M. Gladys, Simon, Jason S., Golovko, Andrei, Laverty, Maureen, Vassileva, Galya, Gustafson, Eric L., Rojas-Triana, Alberto, Bober, Loretta A., Hedrick, Joseph A., Monsma, Frederick J., Greene, Jonathan R., Bayne, Marvin L., Murgolo, Nicholas J.

“…Mice lacking GPR103A expression display osteopenia. Analysis of mouse quantitative trait loci literature associated with bone mineral density suggested GPR103A…”
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Preliminary crystallographic analysis of trypanothione reductase from Crithidia fasciculata by Kuriyan, J, Wong, L, Guenther, B D, Murgolo, N J, Cerami, A, Henderson, G B

“…Trypanothione reductase, a flavoprotein disulfide reductase specific to trypanosomatid parasites, has been crystallized by vapor diffusion of a protein…”
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KCa3.1: target and marker for cancer, autoimmune disorder and vascular inflammation? by Chou, Chuan-Chu, Lunn, Charles A, Murgolo, Nicholas J

“…KCa3.1 is a calcium-activated intermediate-conductance potassium ion channel. In humans the channel is expressed in several secretory organs and subtypes of…”
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Effect of Sch 55700, a humanized monoclonal antibody to human interleukin-5, on eosinophilic responses and bronchial hyperreactivity by EGAN, R. W, ATHWAL, D, INDELICATO, S. R, JENH, C.-H, KREUTNER, W, KUNG, T. T, MAUSER, P. J, MINNICOZZI, M, MURGOLO, N. J, NARULA, S. K, PETRO, M. E, SCHILLING, A, BODMER, M. W, SEHRING, S, STELTS, D, STEPHENS, S, TAREMI, S. S, WEINER, S. H, ZAVODNY, P. J, ZURCHER, J, CARTER, J. M, CHAPMAN, R. W, CHOU, C.-C, COX, M. A, EMTAGE, J. S, FERNANDEZ, X, GENATT, N

“…This report describes the development and the biology of Sch 55700, a humanized monoclonal antibody to human IL-5 (hIL-5). Sch 55700 was synthesized using CDR…”
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