Search Results - "Murgola, Emanuel J."

Interaction of Thiostrepton and Elongation Factor-G with the Ribosomal Protein L11-binding Domain by Bowen, William S., Van Dyke, Natalya, Murgola, Emanuel J., Lodmell, J. Stephen, Hill, Walter E.

“…Ribosomal protein L11 and the L11 binding region of ribosomal RNA constitute an important domain involved in active functions of the ribosome during…”
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The Role of Ribosomal Protein L11 in Class I Release Factor-mediated Translation Termination and Translational Accuracy by Bouakaz, Lamine, Bouakaz, Elli, Murgola, Emanuel J., Ehrenberg, Måns, Sanyal, Suparna

“…It has been suggested from in vivo and cryoelectron micrographic studies that the large ribosomal subunit protein L11 and its N-terminal domain play an…”
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Limitation of Ribosomal Protein L11 Availability in vivo Affects Translation Termination by Van Dyke, Natalya, Xu, Wenbing, Murgola, Emanuel J.

“…Historically referred to as “the GTPase center”, the L11 binding region (L11BR) of Escherichia coli 23 S rRNA is a highly conserved structure that has been…”
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Mutations in the GTPase Center of Escherichia coli 23S rRNA Indicate Release Factor 2-Interactive Sites by Xu, Wenbing, Pagel, Frances T, Murgola, Emanuel J

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Mutational Evidence for a Functional Connection between Two Domains of 23S rRNA in Translation Termination by Arkov, Alexey L., Hedenstierna, Klas O. F., Murgola, Emanuel J.

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An rRNA Fragment and Its Antisense Can Alter Decoding of Genetic Information by Arkov, A L, Mankin, A, Murgola, E J

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Covariance of Complementary rRNA Loop Nucleotides Does Not Necessarily Represent Functional Pseudoknot Formation In Vivo by Chernyaeva, N S, Murgola, E J

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Targeting random mutations to regions that are not flanked by existing restriction sites by Hedenstierna, K O, Murgola, E J

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Suppression of Nonsense Mutations Induced by Expression of an RNA Complementary to a Conserved Segment of 23S rRNA by Chernyaeva, N S, Murgola, E J, Mankin, A S

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UGA Suppression by a Mutant RNA of the Large Ribosomal Subunit by Jemiolo, D K, Pagel, F T, Murgola, E J

“…A role for rRNA in peptide chain termination was indicated several years ago by isolation of a 16S rRNA (small subunit) mutant of Escherichia coli that…”
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Site of Functional Interaction of Release Factor 1 with the Ribosome by Van Dyke, Natalya, Murgola, Emanuel J.

“…Ribosomal protein L11 consists of a C-terminal and an N-terminal domain. To determine the importance of each domain for interaction with release factor 1,…”
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A Base Substitution in the Amino Acid Acceptor Stem of tRNALys Causes Both Misacylation and Altered Decoding by Pagel, Frances T., Murgola, Emanuel J.

“…In 1984, our laboratory reported the characterization of the first misacylated tRNA missense suppressor, a mutant Escherichia coli lysine tRNA with a C70 to U…”
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Mutations in conserved regions of ribosomal RNAs decrease the productive association of peptide-chain release factors with the ribosome during translation termination by Arkov, Alexey L., Freistroffer, David V., Pavlov, Michael Yu, Ehrenberg, Måns, Murgola, Emanuel J.

“…Early studies provided evidence that peptide-chain release factors (RFs) bind to both ribosomal subunits and trigger translation termination. Although many…”
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Phenotypic heterogeneity of mutational changes at a conserved nucleotide in 16 s ribosomal RNA by Pagel, Frances T, Zhao, Song Q, Hijazi, Kathryn A, Murgola, Emanuel J

“…RNA sites that contain unpaired or mismatched nucleotides can be interaction sites for other macromolecules. C1054, a virtually universally conserved…”
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Co-conservation of rRNA tetraloop sequences and helix length suggests involvement of the tetraloops in higher-order interactions by Hedenstierna, Klas O.F, Siefert, Janet L, Fox, George E, Murgola, Emanuel J

“…Terminal loops containing four nucleotides (tetraloops) are common in structural RNAs, and they frequently conform to one of three sequence motifs, GNRA, UNCG,…”
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Variety of nonsense suppressor phenotypes associated with mutational changes at conserved sites in Escherichia coli ribosomal RNA by Murgola, E J, Pagel, F T, Hijazi, K A, Arkov, A L, Xu, W, Zhao, S Q

“…To screen for ribosomal RNA mutants defective in peptide chain termination, we have been looking for rRNA mutants that exhibit different patterns of…”
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Mutational eidence for a functional connection between two domains of 23S rRNA in translation termination by Arkov, Alexey L, Hedenstierna, Klas O F, Murgola, Emanuel J

“…Nucleotide 1093 in domain II of Escherichia coli 23S rRNA is part of a highly conserved structure historically referred to as the GTPase center. The mutation…”
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Mutations in RNAs of both ribosomal subunits cause defects in translation termination by Arkov, Alexey L., Freistroffer, David V., Ehrenberg, Måns, Murgola, Emanuel J.

“…Mutations in RNAs of both subunits of the Escherichia coli ribosome caused defects in catalysis of peptidyl‐tRNA hydrolysis in a realistic in vitro termination…”
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Functional Effects of Mutating the Closing G·A Base-pair of a Conserved Hairpin Loop in 23 S Ribosomal RNA by Xu, Wenbing, Murgola, Emanuel J.

“…Recently, Draper and co-workers solved the structure of a hexanucleotide hairpin loop that is conserved in large subunit ribosomal RNAs. (In Escherichia coli,…”
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A Base Substitution in the Amino Acid Acceptor Stem of tRNALys Causes Both Misacylation and Altered Decoding by PAGEL, FRANCES T., MURGOLA, EMANUEL J.

“…In 1984, our laboratory reported the characterization of the first misacylated tRNA missense suppressor, a mutant Escherichia coli lysine tRNA with a C70 to U…”
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