Search Results - "Murga, C"

Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease by PENELA, Petronila, MURGA, Cristina, RIBAS, Catalina, TUTOR, Antonio S, PEREGRIN, Sandra, MAYOR, Federico JR

“…The G protein-coupled receptor kinases (GRKs) participate with arrestins in the regulation and signal propagation of multiple G protein-coupled receptors…”
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63. GRK2 phosphorylates Epac1 to inhibit signaling and prevent chronic inflammatory pain by Singhmar, P, Wang, H, Eijkelkamp, N, Huo, X, Murga, C, Cheng, X, Major, F, Heijnen, C.J, Kavelaars, A

“…The mechanisms underlying the transition from acute to chronic pain remain poorly understood. In mice, reduced expression of G protein-coupled receptor kinase…”
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NPM-ALK phosphorylates WASp Y102 and contributes to oncogenesis of anaplastic large cell lymphoma by Murga-Zamalloa, C A, Mendoza-Reinoso, V, Sahasrabuddhe, A A, Rolland, D, Hwang, S R, McDonnell, S R P, Sciallis, A P, Wilcox, R A, Bashur, V, Elenitoba-Johnson, K, Lim, M S

“…Mechanisms by which NPM-ALK signaling regulates cell migration, invasion and contributes to the oncogenesis of anaplastic large cell lymphoma (ALCL) are not…”
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Novel Molecular Mediators in the Pathway Connecting G-protein-coupled Receptors to MAP Kinase Cascades by Murga, Cristina, Fukuhara, Shigetomo, Gutkind, J.Silvio

“…The family of receptors coupled to heterotrimeric GTP-binding proteins (G proteins) constitutes the largest group of integral membrane proteins involved in…”
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GRK2-Dependent Desensitization Downstream of G Proteins by JURADO-PUEYO, M., CAMPOS, P. M., MAYOR, F., MURGA, C.

“…G protein-coupled receptor kinases (GRKs) are serine/threonine kinases first discovered by its role in receptor desensitization. Phosphorylation of the…”
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NPM-ALK signals through glycogen synthase kinase 3β to promote oncogenesis by McDonnell, S R P, Hwang, S R, Basrur, V, Conlon, K P, Fermin, D, Wey, E, Murga-Zamalloa, C, Zeng, Z, Zu, Y, Elenitoba-Johnson, K S J, Lim, M S

“…Anaplastic large cell lymphoma (ALCL) is the most common type of pediatric peripheral T-cell lymphoma. In 70–80% of cases, the chromosomal aberration t…”
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REVEALING HIDDEN PATTERNS: HOW UNSUPERVISED MACHINE LEARNING AND MCA PREDICT SURVIVAL IN NODAL PERIPHERAL T-CELL LYMPHOMA PATIENTS by CO Reichert, G Carneiro, HF Culler, FA Freitas, VG Rocha, CA Murga-Zamalloa, LAPC Lage, R Olimpio, J Pereira

“…Unsupervised machine learning techniques are employed to understand patterns and behaviors of variables in databases. Multiple Correspondence Analysis (MCA),…”
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UNVEILING THE PROGNOSTIC CHALLENGES OF NODAL PERIPHERAL T-CELL LYMPHOMAS: A MULTICENTER REAL-WORLD STUDY by CO Reichert, G Carneiro, HF Culler, FA Freitas, ML Marques-Piubelli, CA Murga-Zamalloa, VG Rocha, LAPC Lage, J Pereira

“…Introduction: Peripheral T-cell lymphomas (PTCL) are a rare group of malignancies derived from mature T-cells or natural killer cells, characterized by…”
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Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1 by Singhmar, Pooja, Huo, XiaoJiao, Eijkelkamp, Niels, Berciano, Susana Rojo, Baameur, Faiza, Mei, Fang C., Zhu, Yingmin, Cheng, Xiaodong, Hawke, David, Mayor, Federico, Murga, Cristina, Heijnen, Cobi J., Kavelaars, Annemieke

“…cAMP signaling plays a key role in regulating pain sensitivity. Here, we uncover a previously unidentified molecular mechanism in which direct phosphorylation…”
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The subcellular and cellular distribution of G protein-coupled receptor kinase 2 in rat brain by Murga, C, Penela, P, Zafra, F, Mayor, F

“…G protein-coupled receptor kinase 2 has been found to phosphorylate and thus regulate the activity of several G protein-coupled receptors implicated in…”
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Association of the regulatory beta-adrenergic receptor kinase with rat liver microsomal membranes by I García-Higuera, P Penela, C Murga, G Egea, P Bonay, J L Benovic, F Mayor, Jr

“…beta-Adrenergic receptor kinase (beta ARK) is a regulatory enzyme involved in the modulation of beta-adrenergic and other G protein-coupled receptors. It has…”
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A Novel Role for Phosphatidylinositol 3-Kinase β in Signaling from G Protein-coupled Receptors to Akt by Murga, Cristina, Fukuhara, Shigetomo, Gutkind, J.Silvio

“…The protein kinase Akt plays a central role in a number of key biological functions including protein synthesis, glucose homeostasis, and the regulation of…”
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Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-κB by MURGA, Cristina, ZOHAR, Muriel, TERAMOTO, Hidemi, GUTKIND, J. Silvio

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A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho by Fukuhara, S, Murga, C, Zohar, M, Igishi, T, Gutkind, J S

“…Small GTP-binding proteins of the Rho family play a critical role in signal transduction. However, there is still very limited information on how they are…”
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Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex by Pece, S, Chiariello, M, Murga, C, Gutkind, J S

“…E-cadherins are surface adhesion molecules localized at the level of adherens junctions, which play a major role in cell adhesiveness by mediating…”
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G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits by Jiménez-Sainz, M Carmen, Murga, Cristina, Kavelaars, Annemieke, Jurado-Pueyo, María, Krakstad, Beate F, Heijnen, Cobi J, Mayor, Jr, Federico, Aragay, Anna M

“…The G protein-coupled receptor kinase 2 (GRK2) phosphorylates and desensitizes ligand-activated G protein-coupled-receptors. Here, evidence is shown for a…”
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GRK6, a gatekeeper of visceral hyperalgesia by Murga, Cristina, Mayor, Federico

“…Visceral pain is one of the most important causes for medical consults, and the most frequent type of painful sensation caused by disease (Cervero, F., Laird,…”
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Functional roles of Akt signaling in mouse skin tumorigenesis by SEGRELLES, Carmen, RUIZ, Sergio, JORCANO, Jose L, PARAMIO, Jesus M, PEREZ, Paloma, MURGA, Cristina, SANTOS, Mirentxu, BUDUNOVA, Irina V, MARTINEZ, Jesus, LARCHER, Fernando, SLAGA, Thomas J, GUTKIND, J. Silvio

“…The mouse skin carcinogenesis protocol is a unique model for understanding the molecular events leading to oncogenic transformation. Mutations in the Ha-ras…”
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G protein-coupled receptor kinases: Specific phosphorylation of 7TM receptors and beyond by Murga, C., Penela, P., Ribas, C., Mayor, F

“…G protein-coupled receptor kinases (GRK) have been classically considered as negative regulators of G protein-coupled receptors. However, cumulative evidence…”
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PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells by YONG CHOI, JIE ZHANG, MURGA, Cristina, HONG YU, KOLLER, Erich, MONIA, Brett P, GUTKIND, J. Silvio, WEIQUN LI

“…Expression of PTEN tumor suppressor gene has been known to dephosphorylate the phosphatidylinositol 3' kinase (PI3K) products on the 3 prime inositol ring,…”
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