Search Results - "Murate, T"

Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells by Sobue, S., Nemoto, S., Murakami, M., Ito, H., Kimura, A., Gao, S., Furuhata, A., Takagi, A., Kojima, T., Nakamura, M., Ito, Y., Suzuki, M., Banno, Y., Nozawa, Y., Murate, T.

“…We recently reported increased sphingosine kinase 1 ( SPHK1 ) and decreased neutral sphingomyelinase 2 ( NSMase2 ) gene expression in myelodysplastic syndromes…”
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A possible mechanism for Inv22‐related F8 large deletions in severe hemophilia A patients with high responding factor VIII inhibitors by FUJITA, J., MIYAWAKI, Y., SUZUKI, A., MAKI, A., OKUYAMA, E., MURATA, M., TAKAGI, A., MURATE, T., SUZUKI, N., MATSUSHITA, T., SAITO, H., KOJIMA, T.

“…Background:  Intron 22 inversion (Inv22) of the coagulation factor (F)VIII gene (F8) is a frequent cause of severe hemophilia A. In addition to Inv22, a…”
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Quantitative RT-PCR analysis of sphingolipid metabolic enzymes in acute leukemia and myelodysplastic syndromes by Sobue, S, Iwasaki, T, Sugisaki, C, Nagata, K, Kikuchi, R, Murakami, M, Takagi, A, Kojima, T, Banno, Y, Akao, Y, Nozawa, Y, Kannagi, R, Suzuki, M, Abe, A, Naoe, T, Murate, T

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v-Src oncogene product increases sphingosine kinase 1 expression through mRNA stabilization: alteration of AU-rich element-binding proteins by Sobue, S, Murakami, M, Banno, Y, Ito, H, Kimura, A, Gao, S, Furuhata, A, Takagi, A, Kojima, T, Suzuki, M, Nozawa, Y, Murate, T

“…Sphingosine kinase 1 (SPHK1) is overexpressed in solid tumors and leukemia. However, the mechanism of SPHK1 overexpression by oncogenes has not been defined…”
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Sphingosine kinase 1 expression is downregulated during differentiation of Friend cells due to decreased c-MYB by Mizutani, N., Kobayashi, M., Sobue, S., Ichihara, M., Ito, H., Tanaka, K., Iwaki, S., Fujii, S., Ito, Y., Tamiya-Koizumi, K., Takagi, A., Kojima, T., Naoe, T., Suzuki, M., Nakamura, M., Banno, Y., Nozawa, Y., Murate, T.

“…Sphingosine kinase 1 (SPHK1) overexpression in malignant cells has been reported. Mouse Friend cells showed higher SPHK1 but not SPHK2 expression compared with…”
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Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor‐induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12 by Sobue, S., Hagiwara, K., Banno, Y., Tamiya‐Koizumi, K., Suzuki, M., Takagi, A., Kojima, T., Asano, H., Nozawa, Y., Murate, T.

“…Sphingosine kinase (SPHK) is known to exert an anti‐apoptic role in various cells and cell lines. We previously reported that human brain is rich in SPHK1…”
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GATA-1 and GATA-2 binding to 3′ enhancer of WT1 gene is essential for its transcription in acute leukemia and solid tumor cell lines by Furuhata, A, Murakami, M, Ito, H, Gao, S, Yoshida, K, Sobue, S, Kikuchi, R, Iwasaki, T, Takagi, A, Kojima, T, Suzuki, M, Abe, A, Naoe, T, Murate, T

“…Although oncogenic functions and the clinical significance of Wilms tumor 1 ( WT1 ) have been extensively studied in acute leukemia, the regulatory mechanism…”
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Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia : a new approach to anti-leukemia therapy by KOSUGI, H, TOWATARI, M, NAOE, T, HATANO, S, KITAMURA, K, KIYOI, H, KINOSHITA, T, TANIMOTO, M, MURATE, T, KAWASHIMA, K, SAITO, H

“…We investigated the effect of the histone deacetylase inhibitors (HDIs), trichostatin A and trapoxin A on leukemia cells and cell lines from the viewpoint of…”
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Molecular mechanisms of syndecan-4 upregulation by TNF-  in the endothelium-like EAhy926 cells by Okuyama, E., Suzuki, A., Murata, M., Ando, Y., Kato, I., Takagi, Y., Takagi, A., Murate, T., Saito, H., Kojima, T.

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p27 deregulation by Skp2 overexpression induced by the JAK2V617 mutation by Furuhata, A., Kimura, A., Shide, K., Shimoda, K., Murakami, M., Ito, H., Gao, S., Yoshida, K., Tagawa, Y., Hagiwara, K., Takagi, A., Kojima, T., Suzuki, M., Abe, A., Naoe, T., Murate, T.

“…Janus kinase 2 ( JAK2) V617F mutation has been regarded as the major cause of myeloproliferative disorders (MPD). However, the mechanisms of abnormal cell…”
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Feasibility and pharmacokinetic study of a chimeric anti-CD20 monoclonal antibody (IDEC-C2B8, rituximab) in relapsed B-cell lymphoma by Tobinai, K., Kobayashi, Y., Narabayashi, M., Ogura, M., Kagami, Y., Morishima, Y., Ohtsu, T., Igarashi, T., Sasaki, Y., Kinoshita, T., Murate, T.

“…Background In clinical trials in the USA, IDEC-C2B8 (a mouse-human chimeric anti-CD20 monoclonal antibody) has demonstrated high response rates with only mild…”
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Factors affecting toxicity, response and progression-free survival in relapsed patients with indolent B-cell lymphoma and mantle cell lymphoma treated with rituximab: a Japanese phase II study by Igarashi, T., Kobayashi, Y., Ogura, M., Kinoshita, T., Ohtsu, T., Sasaki, Y., Morishima, Y., Murate, T., Kasai, M., Uike, N., Taniwaki, M., Kano, Y., Ohnishi, K., Matsuno, Y., Nakamura, S., Mori, S., Ohashi, Y., Tobinai, K.

“…Background The aim of the study was to determine factors affecting the toxicity and efficacy of rituximab monotherapy in relapsed patients with indolent B-cell…”
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Ewing's sarcoma fusion protein, EWS Fli-1 and Fli-1 protein induce PLD2 but not PLD1 gene expression by binding to an ETS domain of 5′ promoter by KIKUCHI, R, MURAKAMI, M, NOZAWA, Y, MURATE, T, SOBUE, S, IWASAKIL, T, HAGIWARA, K, TAKAGI, A, KOJIMA, T, ASANO, H, SUZUKI, M, BANNO, Y

“…It was reported that short interfering RNA (siRNA) of EWS/Fli-1 downregulated phospholipase D (PLD)2 in Ewing's sarcoma (EWS) cell line, suggesting that PLD2…”
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Skewed X chromosome inactivation in fraternal female twins results in moderately severe and mild haemophilia B by OKUMURA, K., FUJIMORI, Y., TAKAGI, A., MURATE, T., OZEKI, M., YAMAMOTO, K., KATSUMI, A., MATSUSHITA, T., NAOE, T., KOJIMA, T.

“…Female carriers of haemophilia B are usually asymptomatic; however, the disease resulting from different pathophysiological mechanisms has rarely been…”
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CD20-negative relapse in B-cell lymphoma after treatment with Rituximab by Kinoshita, T, Nagai, H, Murate, T, Saito, H

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Multiple functions of tissue inhibitors of metalloproteinases (TIMPs): new aspects in hematopoiesis by Murate, T.

“…The extracellular matrix (ECM), the product of stromal cells, is now thought to make a dynamic network in tissues. Stromal cells can support other cells not…”
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In vitro characterization of missense mutations associated with quantitative protein S deficiency by OKADA, H., YAMAZAKI, T., TAKAGI, A., MURATE, T., YAMAMOTO, K., TAKAMATSU, J., MATSUSHITA, T., NAOE, T., KUNISHIMA, S., HAMAGUCHI, M., SAITO, H., KOJIMA, T.

“…Objective: To elucidate the molecular consequences of hereditary protein S (PS) deficiency, we investigated the in vitro synthesis of the PS missense mutants…”
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A case of coagulation factor V deficiency caused by compound heterozygous mutations in the factor V gene by YAMAKAGE, N., IKEJIRI, M., OKUMURA, K., TAKAGI, A., MURATE, T., MATUSHITA, T., NAOE, T., YAMAMOTO, K., TAKAMATSU, J., YAMAZAKI, T., HAMAGUCHI, M., KOJIMA, T.

“…We investigated the molecular basis of a severe factor V (FV) deficiency in a Japanese female, and identified two distinct mutations in the FV gene, a novel…”
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L1503R is a member of group I mutation and has dominant-negative effect on secretion of full-length VWF multimers: an analysis of two patients with type 2A von Willebrand disease by KASHIWAGI, T., MATSUSHITA, T., ITO, Y., HIRASHIMA, K., SANDA, N., FUJIMORI, Y., YAMADA, T., OKUMURA, K., TAKAGI, A., MURATE, T., KATSUMI, A., TAKAMATSU, J., YAMAMOTO, K., NAOE, T., KOJIMA, T.

“…Type 2A von Willebrand disease (VWD) is characterized by decreased platelet‐dependent function of von Willebrand factor (VWF); this in turn is associated with…”
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Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma by NAKAHARA, Y, NAGAI, H, KINOSHITA, T, UCHIDA, T, HATANO, S, MURATE, T, SAITO, H

“…The PTEN/MMAC1 gene at 10q23.3, which has dual specific phosphatase activity, is a novel tumor suppressor gene candidate. Various kinds of tumors have…”
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