Search Results - "Muraski, John"

Topical delivery of hyaluronic acid into skin using SPACE-peptide carriers by Chen, Ming, Gupta, Vivek, Anselmo, Aaron C., Muraski, John A., Mitragotri, Samir

“…Topical penetration of macromolecules into the skin is limited by their low permeability. Here, we report the use of a skin penetrating peptide, SPACE peptide,…”
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Topical delivery of siRNA into skin using SPACE-peptide carriers by Chen, Ming, Zakrewsky, Michael, Gupta, Vivek, Anselmo, Aaron C., Slee, Deborah H., Muraski, John A., Mitragotri, Samir

“…Short-interfering RNAs (siRNAs) offer a potential tool for the treatment of skin disorders. However, applications of siRNA for dermatological conditions are…”
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Peptides as skin penetration enhancers: Mechanisms of action by Kumar, Sunny, Zakrewsky, Michael, Chen, Ming, Menegatti, Stefano, Muraski, John A., Mitragotri, Samir

“…Skin penetrating peptides (SPPs) have garnered wide attention in recent years and emerged as a simple and effective noninvasive strategy for macromolecule…”
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Activation of Notch-Mediated Protective Signaling in the Myocardium by Gude, Natalie A, Emmanuel, Gregory, Wu, Weitao, Cottage, Christopher T, Fischer, Kimberlee, Quijada, Pearl, Muraski, John A, Alvarez, Roberto, Rubio, Marta, Schaefer, Eric, Sussman, Mark A

“…The Notch network regulates multiple cellular processes, including cell fate determination, development, differentiation, proliferation, apoptosis, and…”
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Topical delivery of Cyclosporine A into the skin using SPACE-peptide by Chen, Ming, Kumar, Sunny, Anselmo, Aaron C., Gupta, Vivek, Slee, Deborah H., Muraski, John A., Mitragotri, Samir

“…Cyclosporine A (CsA) is used for the treatment of psoriasis; however systemic administration of CsA is potentially life threatening and there are long-term…”
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De Novo Design of Skin-Penetrating Peptides for Enhanced Transdermal Delivery of Peptide Drugs by Menegatti, Stefano, Zakrewsky, Michael, Kumar, Sunny, De Oliveira, Joshua Sanchez, Muraski, John A., Mitragotri, Samir

“…Skin‐penetrating peptides (SPPs) are attracting increasing attention as a non‐invasive strategy for transdermal delivery of therapeutics. The identification of…”
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Bone marrow cells adopt the cardiomyogenic fate in vivo by Rota, Marcello, Kajstura, Jan, Hosoda, Toru, Bearzi, Claudia, Vitale, Serena, Esposito, Grazia, Iaffaldano, Grazia, Padin-Iruegas, M. Elena, Gonzalez, Arantxa, Rizzi, Roberto, Small, Narissa, Muraski, John, Alvarez, Roberto, Chen, Xiongwen, Urbanek, Konrad, Bolli, Roberto, Houser, Steven R, Leri, Annarosa, Sussman, Mark A, Anversa, Piero

“…The possibility that adult bone marrow cells (BMCs) retain a remarkable degree of developmental plasticity and acquire the cardiomyocyte lineage after…”
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Evolution of the c‐kit‐Positive Cell Response to Pathological Challenge in the Myocardium by Fransioli, Jenna, Bailey, Brandi, Gude, Natalie A., Cottage, Christopher T., Muraski, John A., Emmanuel, Gregory, Wu, Weitao, Alvarez, Roberto, Rubio, Marta, Ottolenghi, Sergio, Schaefer, Erik, Sussman, Mark A.

“…Cumulative evidence indicates that myocardium responds to growth or injury by recruitment of stem and/or progenitor cells that participate in repair and…”
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Cardiac Progenitor Cell Cycling Stimulated by Pim-1 Kinase by Cottage, Christopher T, Bailey, Brandi, Fischer, Kimberlee M, Avitable, Daniele, Collins, Brett, Tuck, Savilla, Quijada, Pearl, Gude, Natalie, Alvarez, Roberto, Muraski, John, Sussman, Mark A

“…RATIONALE:Cardioprotective effects of Pim-1 kinase have been previously reported but the underlying mechanistic basis may involve a combination of cellular and…”
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Formation of large coronary arteries by cardiac progenitor cells by Tillmanns, Jochen, Rota, Marcello, Hosoda, Toru, Misao, Yu, Esposito, Grazia, Gonzalez, Arantxa, Vitale, Serena, Parolin, Carola, Yasuzawa-Amano, Saori, Muraski, John, De Angelis, Antonella, LeCapitaine, Nicole, Siggins, Robert W, Loredo, Maria, Bearzi, Claudia, Bolli, Roberto, Urbanek, Konrad, Leri, Annarosa, Kajstura, Jan, Anversa, Piero

“…Coronary artery disease is the most common cause of cardiac failure in the Western world, and to date there is no alternative to bypass surgery for severe…”
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Akt Promotes Increased Cardiomyocyte Cycling and Expansion of the Cardiac Progenitor Cell Population by Gude, Natalie, Muraski, John, Rubio, Marta, Kajstura, Jan, Schaefer, Erik, Anversa, Piero, Sussman, Mark A

“…Activation of Akt is associated with enhanced cell cycling and cellular proliferation in nonmyocytes, but this effect of nuclear Akt accumulation has not been…”
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Mechanistic Analysis of Cellular Internalization of a Cell- and Skin-Penetrating Peptide by Zakrewsky, Michael, Muraski, John A., Mitragotri, Samir

“…Background Keratinocytes are a targeted cell-type for treating skin disease. However, delivering drugs into the skin and keratinocytes remains challenging due…”
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Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload by Muraski, John A, Fischer, Kimberlee M, Wu, Weitao, Cottage, Christopher T, Quijada, Pearl, Mason, Matt, Din, Shabana, Gude, Natalie, Alvarez, Roberto Jr, Rota, Marcello, Kajstura, Jan, Wang, Zeping, Schaefer, Erik, Chen, Xiongen, MacDonnel, Scott, Magnuson, Nancy, Houser, Stephen R, Anversa, Piero, Sussman, Mark A

“…Pim-1 kinase exerts potent cardioprotective effects in the myocardium downstream of AKT, but the participation of Pim-1 in cardiac hypertrophy requires…”
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Pim-1 regulates cardiomyocyte survival downstream of Akt by Sussman, Mark A, Muraski, John A, Rota, Marcello, Misao, Yu, Fransioli, Jenna, Cottage, Christopher, Gude, Natalie, Esposito, Grazia, Delucchi, Francesca, Arcarese, Michael, Alvarez, Roberto, Siddiqi, Sailay, Emmanuel, Gregory N, Wu, Weitao, Fischer, Kimberlee, Martindale, Joshua J, Glembotski, Christopher C, Leri, Annarosa, Kajstura, Jan, Magnuson, Nancy, Berns, Anton, Beretta, Remus M, Houser, Steven R, Schaefer, Erik M, Anversa, Piero

“…The serine-threonine kinases Pim-1 and Akt regulate cellular proliferation and survival. Although Akt is known to be a crucial signaling protein in the…”
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Enhanced epidermal localization of topically applied steroids using SPACE™ peptide by Kumar, Sunny, Chen, Ming, Anselmo, Aaron C., Muraski, John A., Mitragotri, Samir

“…The balance of efficacy and safety of topical corticosteroids (TCs) depends on their ability to penetrate into and be retained within the skin. Here, we…”
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Myocardial Induction of Nucleostemin in Response to Postnatal Growth and Pathological Challenge by Siddiqi, Sailay, Gude, Natalie, Hosoda, Toru, Muraski, John, Rubio, Marta, Emmanuel, Gregory, Fransioli, Jenna, Vitale, Serena, Parolin, Carola, D’Amario, Domenico, Schaefer, Erik, Kajstura, Jan, Leri, Annarosa, Anversa, Piero, Sussman, Mark A

“…Stem cell–specific proteins and regulatory pathways that determine self-renewal and differentiation have become of fundamental importance in understanding…”
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Nuclear Targeting of Akt Antagonizes Aspects of Cardiomyocyte Hypertrophy by Tsujita, Yasuyuki, Muraski, John, Shiraishi, Isao, Kato, Takahiro, Kajstura, Jan, Anversa, Piero, Sussman, Mark A.

“…The serine/threonine kinase Akt regulates cellular survival, proliferation, gene transcription, protein translation, metabolism, and differentiation. Although…”
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Abstract 5415: Targeted nanoparticle based therapy for the treatment of glioblastoma multiforme: Unprecedented anti-cancer activity in highly drug resistant/refractory mouse models of glioblastoma with novel apoptotic nanoparticles which hone to a cell-surface protein f by Hudson, Sarah, Agemy, Lilach, Kotamraju, Venkata Ramana, Sharma, Shweta, Ruoslahti, Erkki, Brunel, Florence, MacLaren, Ann, Muraski, John, Slee, Deborah

“…Glioblastoma multiforme (GBM) or “glioblastoma,” is the most common and aggressive malignant primary brain tumor in humans. An effective treatment that…”
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Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt by Kato, Takahiro, Muraski, John, Chen, Yan, Tsujita, Yasuyuki, Wall, Jason, Glembotski, Christopher C, Schaefer, Erik, Beckerle, Mary, Sussman, Mark A

“…This study delineates a mechanism for antiapoptotic signaling initiated by atrial natriuretic peptide (ANP) stimulation leading to elevation of cGMP levels and…”
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Abstract 1414: Pim-1 Stimulates Cardiac Progenitor Cell Proliferation And Asymmetric Division by Cottage, Christopher T, Tuck, Savilla, Fischer, Kimberlee, Gude, Natalie, Muraski, John, Sussman, Mark A

“…Abstract only Cardiac progenitor cells (CPCs) blunt cardiomyopathic damage and increase survival following adoptive transfer into hearts subjected to…”
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