Search Results - "Muraoka, Naoto"

Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine by Karbassi, Elaheh, Fenix, Aidan, Marchiano, Silvia, Muraoka, Naoto, Nakamura, Kenta, Yang, Xiulan, Murry, Charles E.

“…Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we now can generate most cells of the human body in the laboratory…”
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Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming by Muraoka, Naoto, Nara, Kaori, Tamura, Fumiya, Kojima, Hidenori, Yamakawa, Hiroyuki, Sadahiro, Taketaro, Miyamoto, Kazutaka, Isomi, Mari, Haginiwa, Sho, Tani, Hidenori, Kurotsu, Shota, Osakabe, Rina, Torii, Satoru, Shimizu, Shigeomi, Okano, Hideyuki, Sugimoto, Yukihiko, Fukuda, Keiichi, Ieda, Masaki

“…Direct cardiac reprogramming from fibroblasts can be a promising approach for disease modeling, drug screening, and cardiac regeneration in pediatric and adult…”
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Distinct Metabolic Flow Enables Large-Scale Purification of Mouse and Human Pluripotent Stem Cell-Derived Cardiomyocytes by Tohyama, Shugo, Hattori, Fumiyuki, Sano, Motoaki, Hishiki, Takako, Nagahata, Yoshiko, Matsuura, Tomomi, Hashimoto, Hisayuki, Suzuki, Tomoyuki, Yamashita, Hiromi, Satoh, Yusuke, Egashira, Toru, Seki, Tomohisa, Muraoka, Naoto, Yamakawa, Hiroyuki, Ohgino, Yasuyuki, Tanaka, Tomofumi, Yoichi, Masatoshi, Yuasa, Shinsuke, Murata, Mitsushige, Suematsu, Makoto, Fukuda, Keiichi

“…Heart disease remains a major cause of death despite advances in medical technology. Heart-regenerative therapy that uses pluripotent stem cells (PSCs) is a…”
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Induction of human cardiomyocyte-like cells from fibroblasts by defined factors by Wada, Rie, Muraoka, Naoto, Inagawa, Kohei, Yamakawa, Hiroyuki, Miyamoto, Kazutaka, Sadahiro, Taketaro, Umei, Tomohiko, Kaneda, Ruri, Suzuki, Tomoyuki, Kamiya, Kaichiro, Tohyama, Shugo, Yuasa, Shinsuke, Kokaji, Kiyokazu, Aeba, Ryo, Yozu, Ryohei, Yamagishi, Hiroyuki, Kitamura, Toshio, Fukuda, Keiichi, Ieda, Masaki

“…Heart disease remains a leading cause of death worldwide. Owing to the limited regenerative capacity of heart tissue, cardiac regenerative therapy has emerged…”
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MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures by Muraoka, Naoto, Yamakawa, Hiroyuki, Miyamoto, Kazutaka, Sadahiro, Taketaro, Umei, Tomohiko, Isomi, Mari, Nakashima, Hanae, Akiyama, Mizuha, Wada, Rie, Inagawa, Kohei, Nishiyama, Takahiko, Kaneda, Ruri, Fukuda, Toru, Takeda, Shu, Tohyama, Shugo, Hashimoto, Hisayuki, Kawamura, Yoshifumi, Goshima, Naoki, Aeba, Ryo, Yamagishi, Hiroyuki, Fukuda, Keiichi, Ieda, Masaki

“…Fibroblasts can be directly reprogrammed into cardiomyocyte‐like cells (iCMs) by overexpression of cardiac transcription factors or microRNAs. However,…”
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Induction of Cardiomyocyte-Like Cells in Infarct Hearts by Gene Transfer of Gata4, Mef2c, and Tbx5 by Inagawa, Kohei, Miyamoto, Kazutaka, Yamakawa, Hiroyuki, Muraoka, Naoto, Sadahiro, Taketaro, Umei, Tomohiko, Wada, Rie, Katsumata, Yoshinori, Kaneda, Ruri, Nakade, Koji, Kurihara, Chitose, Obata, Yuichi, Miyake, Koichi, Fukuda, Keiichi, Ieda, Masaki

“…RATIONALE:After myocardial infarction (MI), massive cell death in the myocardium initiates fibrosis and scar formation, leading to heart failure. We recently…”
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Stoichiometry of Transcription Factors Is Critical for Cardiac Reprogramming by Muraoka, Naoto, Ieda, Masaki

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Dermal fibroblast-like cells reprogrammed directly from adipocytes in mouse by Toyosaki, Mitsunobu, Homma, Koichiro, Suzuki, Sayuri, Muraoka, Naoto, Hashimoto, Hisayuki, Goshima, Naoki, Ieda, Masaki, Sasaki, Junichi

“…In deep burns, early wound closure is important for healing, and skin grafting is mainly used for wound closure. However, it is difficult to achieve early…”
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Fibroblast Growth Factors and Vascular Endothelial Growth Factor Promote Cardiac Reprogramming under Defined Conditions by Yamakawa, Hiroyuki, Muraoka, Naoto, Miyamoto, Kazutaka, Sadahiro, Taketaro, Isomi, Mari, Haginiwa, Sho, Kojima, Hidenori, Umei, Tomohiko, Akiyama, Mizuha, Kuishi, Yuki, Kurokawa, Junko, Furukawa, Tetsushi, Fukuda, Keiichi, Ieda, Masaki

“…Fibroblasts can be directly reprogrammed into cardiomyocyte-like cells (iCMs) by overexpression of cardiac transcription factors, including Gata4, Mef2c, and…”
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Distinct expression patterns of Flk1 and Flt1 in the coronary vascular system during development and after myocardial infarction by Kurotsu, Shota, Osakabe, Rina, Isomi, Mari, Tamura, Fumiya, Sadahiro, Taketaro, Muraoka, Naoto, Kojima, Hidenori, Haginiwa, Sho, Tani, Hidenori, Nara, Kaori, Kubota, Yoshiaki, Ema, Masatsugu, Fukuda, Keiichi, Suzuki, Takeshi, Ieda, Masaki

“…The coronary vascular system is critical for myocardial growth and cardiomyocyte survival. However, the molecular mechanism regulating coronary angiogenesis…”
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Single-Construct Polycistronic Doxycycline-Inducible Vectors Improve Direct Cardiac Reprogramming and Can Be Used to Identify the Critical Timing of Transgene Expression by Umei, Tomohiko C, Yamakawa, Hiroyuki, Muraoka, Naoto, Sadahiro, Taketaro, Isomi, Mari, Haginiwa, Sho, Kojima, Hidenori, Kurotsu, Shota, Tamura, Fumiya, Osakabe, Rina, Tani, Hidenori, Nara, Kaori, Miyoshi, Hiroyuki, Fukuda, Keiichi, Ieda, Masaki

“…Direct reprogramming is a promising approach in regenerative medicine. Overexpression of the cardiac transcription factors Gata4, Mef2c, and Tbx5 (GMT) or GMT…”
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Time-lapse imaging of cell cycle dynamics during development in living cardiomyocyte by Hashimoto, Hisayuki, Yuasa, Shinsuke, Tabata, Hidenori, Tohyama, Shugo, Hayashiji, Nozomi, Hattori, Fumiyuki, Muraoka, Naoto, Egashira, Toru, Okata, Shinichiro, Yae, Kojiro, Seki, Tomohisa, Nishiyama, Takahiko, Nakajima, Kazunori, Sakaue-Sawano, Asako, Miyawaki, Atsushi, Fukuda, Keiichi

“…Abstract Mammalian cardiomyocytes withdraw from the cell cycle shortly after birth, although it remains unclear how cardiomyocyte cell cycles behave during…”
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Positional desaturation due to persistent left superior vena cava draining into the left atrium by Shirakawa, Kousuke, Kawamura, Akio, Muraoka, Naoto, Murata, Mitsushige, Tsuruta, Hikaru, Aeba, Ryo, Fukuda, Keiichi

“…Persistent left superior vena cava (PLSVC) is a rare congenital anomaly whose prevalence is 0.3 % of general population. The majority of PLSVC drain into right…”
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Analysis of cardiomyocyte movement in the developing murine heart by Hashimoto, Hisayuki, Yuasa, Shinsuke, Tabata, Hidenori, Tohyama, Shugo, Seki, Tomohisa, Egashira, Toru, Hayashiji, Nozomi, Hattori, Fumiyuki, Kusumoto, Dai, Kunitomi, Akira, Takei, Makoto, Kashimura, Shin, Yozu, Gakuto, Shimojima, Masaya, Motoda, Chikaaki, Muraoka, Naoto, Nakajima, Kazunori, Sakaue-Sawano, Asako, Miyawaki, Atsushi, Fukuda, Keiichi

“…The precise assemblage of several types of cardiac precursors controls heart organogenesis. The cardiac precursors show dynamic movement during early…”
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Direct reprogramming of fibroblasts into myocytes to reverse fibrosis by Muraoka, Naoto, Ieda, Masaki

“…Heart disease is a major cause of morbidity and mortality worldwide. The low regenerative capacity of adult human hearts has thus far limited the available…”
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Abstract P1130: Enhanced Electrophysiological Maturation Of Human Pluripotent Stem Cell Derived Cardiomyocytes By An Optimal Combination Of Metabolic Modulators by Muraoka, Naoto, Alavattam, Kris, Yang, Xiulan, Reinecke, Hans, Klaiman, Jordan, Murry, Charles

“…Abstract only Human pluripotent stem cell derived cardiomyocytes (hPSC-CMs) have emerged as ideal cell source for heart regeneration. Transplantation of…”
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A Proteomic Perspective on Cardiomyocyte Maturation by Muraoka, Naoto, Sun, Bingyun, Murry, Charles E

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Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction by Miyamoto, Kazutaka, Akiyama, Mizuha, Tamura, Fumiya, Isomi, Mari, Yamakawa, Hiroyuki, Sadahiro, Taketaro, Muraoka, Naoto, Kojima, Hidenori, Haginiwa, Sho, Kurotsu, Shota, Tani, Hidenori, Wang, Li, Qian, Li, Inoue, Makoto, Ide, Yoshinori, Kurokawa, Junko, Yamamoto, Tsunehisa, Seki, Tomohisa, Aeba, Ryo, Yamagishi, Hiroyuki, Fukuda, Keiichi, Ieda, Masaki

“…Direct cardiac reprogramming holds great promise for regenerative medicine. We previously generated directly reprogrammed induced cardiomyocyte-like cells…”
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Blunted Cardiac Mitophagy in Response to Metabolic Stress Contributes to HFpEF by Yoshii, Akira, McMillen, Timothy S, Wang, Yajun, Zhou, Bo, Chen, Hongye, Banerjee, Durba, Herrero, Melisa, Wang, Pei, Muraoka, Naoto, Wang, Wang, Murry, Charles E, Tian, Rong

“…Metabolic remodeling and mitochondrial dysfunction are hallmarks of heart failure with reduced ejection fraction. However, their role in the pathogenesis of HF…”
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Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification by Sadahiro, Taketaro, Isomi, Mari, Muraoka, Naoto, Kojima, Hidenori, Haginiwa, Sho, Kurotsu, Shota, Tamura, Fumiya, Tani, Hidenori, Tohyama, Shugo, Fujita, Jun, Miyoshi, Hiroyuki, Kawamura, Yoshifumi, Goshima, Naoki, Iwasaki, Yuka W., Murano, Kensaku, Saito, Kuniaki, Oda, Mayumi, Andersen, Peter, Kwon, Chulan, Uosaki, Hideki, Nishizono, Hirofumi, Fukuda, Keiichi, Ieda, Masaki

“…The mesoderm arises from pluripotent epiblasts and differentiates into multiple lineages; however, the underlying molecular mechanisms are unclear. Tbx6 is…”
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