Search Results - "Muraoka, Daisuke"

Discovery of a New STAT3 Inhibitor Acting on the Linker Domain by Koseki, Tatsuya, Suehiro, Naoya, Masuda, Yoshiaki, Miyoshi, Nao, Muraoka, Daisuke, Ogo, Naohisa, Asai, Akira

“…Signal transducer and activator of transcription 3 (STAT3) is a latent transcription factor that contributes to tumor cell growth and survival and is often…”
Get full text

CD4+ T cells support polyfunctionality of cytotoxic CD8+ T cells with memory potential in immunological control of tumor by Imai, Naoko, Tawara, Isao, Yamane, Makiko, Muraoka, Daisuke, Shiku, Hiroshi, Ikeda, Hiroaki

“…Polyfunctionality/multifunctionality of effector T cells at the single cell level has been shown as an important parameter to predict the quality of T cell…”
Get full text

Nanogel-Based Immunologically Stealth Vaccine Targets Macrophages in the Medulla of Lymph Node and Induces Potent Antitumor Immunity by Muraoka, Daisuke, Harada, Naozumi, Hayashi, Tae, Tahara, Yoshiro, Momose, Fumiyasu, Sawada, Shin-ichi, Mukai, Sada-atsu, Akiyoshi, Kazunari, Shiku, Hiroshi

“…Because existing therapeutic cancer vaccines provide only a limited clinical benefit, a different vaccination strategy is necessary to improve vaccine…”
Get full text

Reduced biomass of the kelp Saccharina japonica cumulatively affects gonad production of sea urchins over ensuing years off northeastern Japan by Yatsuya, Kousuke, Matsumoto, Yukio, Sasaki, Kei, Shirafuji, Norio, Muraoka, Daisuke

“…The annual kelp Saccharina japonica grows along the northeastern coast of Japan, making the coast highly productive for the fishery for herbivores such as sea…”
Get full text

Identification of a dominant CD8+ CTL epitope in the SARS-associated coronavirus 2 spike protein by Muraoka, Daisuke, Situo, Deng, Sawada, Shin-ichi, Akiyoshi, Kazunari, Harada, Naozumi, Ikeda, Hiroaki

“…Coronavirus disease 2019 (COVID-19), which is caused by SARS-CoV-2, has been spreading throughout the world. To date, there are still no approved human…”
Get full text

Effects of the 2011 Great East Japan Earthquake and tsunami on two kelp bed communities on the Sanriku coast by Muraoka, Daisuke, Tamaki, Hitoshi, Takami, Hideki, Kurita, Yutaka, Kawamura, Tomohiko

“…To determine the effects of the tsunami on kelp bed communities, we examined two kelp beds that had been surveyed before 2011 on the Pacific coast of Honshu…”
Get full text

Eisenia bicyclis bed coverage off Oshika Peninsula, Japan, in relation to sporophyte survival and Strongylocentrotus nudus abundance by Muraoka, Daisuke

“…It has recently been reported that the Eisenia bicyclis beds on the coast of Tomarihama in the Oshika Peninsula in Miyagi Prefecture (northern part of Japan)…”
Get full text

First-in-human phase I clinical trial of the NY-ESO-1 protein cancer vaccine with NOD2 and TLR9 stimulants in patients with NY-ESO-1-expressing refractory solid tumors by Ishihara, Mikiya, Tono, Yasutaka, Miyahara, Yoshihiro, Muraoka, Daisuke, Harada, Naozumi, Kageyama, Shinichi, Sasaki, Takeshi, Hori, Yasuhide, Soga, Norihito, Uchida, Katsunori, Shiraishi, Taizo, Sato, Eiichi, Kanda, Hideki, Mizuno, Toshiro, Webster, Gill A., Ikeda, Hiroaki, Katayama, Naoyuki, Sugimura, Yoshiki, Shiku, Hiroshi

“…Cholesteryl pullulan (CHP) is a novel antigen delivery system. CHP and New York esophageal squamous cell carcinoma 1 (NY-ESO-1) antigen complexes…”
Get full text

Interleukin-17 induces an atypical M2-like macrophage subpopulation that regulates intestinal inflammation by Nishikawa, Kenichiro, Seo, Naohiro, Torii, Mie, Ma, Nei, Muraoka, Daisuke, Tawara, Isao, Masuya, Masahiro, Tanaka, Kyosuke, Takei, Yoshiyuki, Shiku, Hiroshi, Katayama, Naoyuki, Kato, Takuma

“…Interleukin 17 (IL-17) is a pleiotropic cytokine that acts on both immune and non-immune cells and is generally implicated in inflammatory and autoimmune…”
Get full text

Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals by Mitsui, Jun, Nishikawa, Hiroyoshi, Muraoka, Daisuke, Wang, Linan, Noguchi, Takuro, Sato, Eiichi, Kondo, Satoshi, Allison, James P, Sakaguchi, Shimon, Old, Lloyd J, Kato, Takuma, Shiku, Hiroshi

“…Blockade of CTL-associated antigen-4 (CTLA-4), an inhibitory immunomodulatory molecule on T cells, has been shown to enhance T-cell responses and induce tumor…”
Get full text

Changes in serum DAMPs and cytokines/chemokines during near‐infrared photoimmunotherapy for patients with head and neck cancer by Ishihara, Hiromasa, Nishikawa, Daisuke, Muraoka, Daisuke, Masago, Katsuhiro, Beppu, Shintaro, Terada, Hoshino, Matsushita, Hirokazu, Hanai, Nobuhiro

“…Background Near‐infrared photoimmunotherapy (NIR‐PIT) for head and neck cancer is a recently developed therapy. However, there is limited data on patients…”
Get full text

Inhibition of STAT3 by Anticancer Drug Bendamustine by Iwamoto, Kazunori, Uehara, Yutaka, Inoue, Yukie, Taguchi, Kyoko, Muraoka, Daisuke, Ogo, Naohisa, Matsuno, Kenji, Asai, Akira

“…Bendamustine (BENDA), which bears the bis(2-chloroethyl)amino moiety, is an alkylating agent that stops the growth of cancer cells by binding to DNA and…”
Get full text

Epirubicin, Identified Using a Novel Luciferase Reporter Assay for Foxp3 Inhibitors, Inhibits Regulatory T Cell Activity by Kashima, Hajime, Momose, Fumiyasu, Umehara, Hiroshi, Miyoshi, Nao, Ogo, Naohisa, Muraoka, Daisuke, Shiku, Hiroshi, Harada, Naozumi, Asai, Akira

“…Forkhead box protein p3 (Foxp3) is crucial to the development and suppressor function of regulatory T cells (Tregs) that have a significant role in…”
Get full text

Phenology of the kelp Saccharina japonica and its effect on the gonad index of the sea urchin Mesocentrotus nudus across a depth gradient off the Sanriku coast, northeastern Japan by Yatsuya, Kousuke, Matsumoto, Yukio, Sasaki, Kei, Shirafuji, Norio, Muraoka, Daisuke

“…The kelp Saccharina japonica is a dominant seaweed along the Sanriku coast where fisheries for sea urchin and abalone are among the most prosperous in Japan…”
Get full text

Candidate tumor-specific CD8 + T cell subsets identified in the malignant pleural effusion of advanced lung cancer patients by single-cell analysis by Sugita, Yusuke, Muraoka, Daisuke, Demachi-Okamura, Ayako, Komuro, Hiroyasu, Masago, Katsuhiro, Sasaki, Eiichi, Fukushima, Yasunori, Matsui, Takuya, Shinohara, Shuichi, Takahashi, Yusuke, Nishida, Reina, Takashima, Chieko, Yamaguchi, Teppei, Horio, Yoshitsugu, Hashimoto, Kana, Tanaka, Ichidai, Hamana, Hiroshi, Kishi, Hiroyuki, Miura, Daiki, Tanaka, Yuki, Onoue, Kousuke, Onoguchi, Kazuhide, Yamashita, Yoshiko, Stratford, Richard, Clancy, Trevor, Yamaguchi, Rui, Kuroda, Hiroaki, Ishibashi, Hironori, Okubo, Kenichi, Matsushita, Hirokazu

“…Isolation of tumor-specific T cells and their antigen receptors (TCRs) from malignant pleural effusions (MPE) may facilitate the development of TCR-transduced…”
Get full text

Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase by Yoshioka, Saeko, Ikeda, Tomonori, Fukuchi, Sogo, Kawai, Yurika, Ohta, Katsumi, Murakami, Hisashi, Ogo, Naohisa, Muraoka, Daisuke, Takikawa, Osamu, Asai, Akira

“…Kynurenine (Kyn), a metabolite of tryptophan (Trp), is a key regulator of mammal immune responses such as cancer immune tolerance. Indoleamine-2,3-dioxygenase…”
Get full text

New evaluation of the tumor immune microenvironment of non-small cell lung cancer and its association with prognosis by Shinohara, Shuichi, Takahashi, Yusuke, Komuro, Hiroyasu, Matsui, Takuya, Sugita, Yusuke, Demachi-Okamura, Ayako, Muraoka, Daisuke, Takahara, Hirotomo, Nakada, Takeo, Sakakura, Noriaki, Masago, Katsuhiro, Miyai, Manami, Nishida, Reina, Shomura, Shin, Shigematsu, Yoshiki, Hatooka, Shunzo, Sasano, Hajime, Watanabe, Fumiaki, Adachi, Katsutoshi, Fujinaga, Kazuya, Kaneda, Shinji, Takao, Motoshi, Ohtsuka, Takashi, Yamaguchi, Rui, Kuroda, Hiroaki, Matsushita, Hirokazu

“…BackgroundA better understanding of the tumor immune microenvironment (TIME) will facilitate the development of prognostic biomarkers and more effective…”
Get full text

Effects of macroalgal expansion triggered by the 2011 earthquake and tsunami on recruitment density of juvenile abalone Haliotis discus hannai at Oshika Peninsula, northeastern Japan by Takami, Hideki, Kawamura, Tomohiko, Won, Nam‐IL, Muraoka, Daisuke, Hayakawa, Jun, Onitsuka, Toshihiro

“…The effects of the 2011 mega‐earthquake and massive tsunami on the recruitment process of juvenile abalone Haliotis discus hannai inhabiting the rocky shore…”
Get full text

The Lewis X-related α1,3-Fucosyltransferase, Fut10, Is Required for the Maintenance of Stem Cell Populations by Kumar, Akhilesh, Torii, Tomohiro, Ishino, Yugo, Muraoka, Daisuke, Yoshimura, Takeshi, Togayachi, Akira, Narimatsu, Hisashi, Ikenaka, Kazuhiro, Hitoshi, Seiji

“…The Lewis X carbohydrate antigen is abundantly expressed in several stem cell populations. Results: Fut10 is responsible for the synthesis of unique types of…”
Get full text

Low-frequency CD8+ T cells induced by SIGN-R1+ macrophage-targeted vaccine confer SARS-CoV-2 clearance in mice by Muraoka, Daisuke, Moi, Meng Ling, Muto, Osamu, Nakatsukasa, Takaaki, Deng, Situo, Takashima, Chieko, Yamaguchi, Rui, Sawada, Shin-ichi, Hayakawa, Haruka, Nguyen, Thi Thanh Ngan, Haseda, Yasunari, Soga, Takatoshi, Matsushita, Hirokazu, Ikeda, Hiroaki, Akiyoshi, Kazunari, Harada, Naozumi

“…Vaccine-induced T cells and neutralizing antibodies are essential for protection against SARS-CoV-2. Previously, we demonstrated that an antigen delivery…”
Get full text