Search Results - "Muranyi, Andrea"

Development of a first-in-class antibody and a specific assay for α-1,6-fucosylated prostate-specific antigen by Halldórsson, Steinar, Hillringhaus, Lars, Hojer, Caroline, Muranyi, Andrea, Schraeml, Michael, Lange, Magdalena Swiatek-de, Tabarés, Gloria

“…Prostate-specific antigen (PSA) levels are widely used to screen for prostate cancer, yet the test has poor sensitivity, specificity and predictive value,…”
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Simultaneous Drug Targeting of the Promoter MYC G‑Quadruplex and BCL2 i‑Motif in Diffuse Large B‑Cell Lymphoma Delays Tumor Growth by Kendrick, Samantha, Muranyi, Andrea, Gokhale, Vijay, Hurley, Laurence H, Rimsza, Lisa M

“…Secondary DNA structures are uniquely poised as therapeutic targets due to their molecular switch function in turning gene expression on or off and…”
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Immune microenvironment in patients with mismatch‐repair‐proficient oligometastatic colorectal cancer exposed to chemotherapy: the randomized MIROX GERCOR cohort study by Jary, Marine, Liu, Wen‐Wei, Yan, Dongyao, Bai, Isaac, Muranyi, Andrea, Colle, Elise, Brocheriou, Isabelle, Turpin, Anthony, Radosevic‐Robin, Nina, Bourgoin, Pierre, Penault‐Llorca, Frédérique, Cohen, Romain, Vernerey, Dewi, André, Thierry, Borg, Christophe, Shanmugam, Kandavel, Svrcek, Magali

“…In the era of immune checkpoint inhibitors, understanding the metastatic microenvironment of proficient mismatch repair/microsatellite stable (pMMR/MSS)…”
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Girdin (GIV) Expression as a Prognostic Marker of Recurrence in Mismatch Repair-Proficient Stage II Colon Cancer by Ghosh, Pradipta, Tie, Jeanne, Muranyi, Andrea, Singh, Shalini, Brunhoeber, Patrick, Leith, Katherine, Bowermaster, Rebecca, Liao, Zhiming, Zhu, Yifei, LaFleur, Bonnie, Tran, Ben, Desai, Jayesh, Jones, Ian, Croxford, Matthew, Jover, Rodrigo, Goel, Ajay, Waring, Paul, Hu, Song, Teichgraber, Volker, Rohr, Ulrich-Peter, Ridder, Ruediger, Shanmugam, Kandavel, Gibbs, Peter

“…Prognostic markers that identify patients with stage II colon cancers who are at the risk of recurrence are essential to personalize therapy. We evaluated the…”
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BCL2 antibodies targeted at different epitopes detect varying levels of protein expression and correlate with frequent gene amplification in diffuse large B-cell lymphoma by Kendrick, Samantha L., PhD, Redd, Lucas, MD, Muranyi, Andrea, PhD, Henricksen, Leigh A., PhD, Stanislaw, Stacey, PhD, Smith, Lynette M., MS, Perry, Anamarija M., MD, Fu, Kai, MD, PhD, Weisenburger, Dennis D., MD, Rosenwald, Andreas, MD, Ott, German, MD, Gascoyne, Randy D., MD, Jaffe, Elaine S., MD, Campo, Elías, MD, PhD, Delabie, Jan, MD, PhD, Braziel, Rita M., MD, Cook, James R., MD, PhD, Tubbs, Raymond R., DO, Staudt, Louis M., MD, PhD, Chan, Wing Chung, MD, Steidl, Christian, MD, Grogan, Thomas M., MD, Rimsza, Lisa M., MD

“…Summary Patients with aggressive, BCL2 protein-positive (+) diffuse large B-cell lymphoma (DLBCL) often experience rapid disease progression that is refractory…”
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MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) by Webb, James D, Murányi, Andrea, Pugh, Christopher W, Ratcliffe, Peter J, Coleman, Mathew L

“…The asparaginyl hydroxylase FIH [factor inhibiting HIF (hypoxia-inducible factor)] was first identified as a protein that inhibits transcriptional activation…”
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Phosphorylation of Thr695 and Thr850 on the myosin phosphatase target subunit: Inhibitory effects and occurrence in A7r5 cells by Murányi, Andrea, Derkach, Dmitry, Erdődi, Ferenc, Kiss, Andrea, Ito, Masaaki, Hartshorne, David J.

“…Major sites for Rho-kinase on the myosin phosphatase target subunit (MYPT1) are Thr695 and Thr850. Phosphorylation of Thr695 inhibits phosphatase activity but…”
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Intertumoral Heterogeneity of CD3 + and CD8 + T-Cell Densities in the Microenvironment of DNA Mismatch-Repair-Deficient Colon Cancers: Implications for Prognosis by Yoon, Harry H, Shi, Qian, Heying, Erica N, Muranyi, Andrea, Bredno, Joerg, Ough, Faith, Djalilvand, Azita, Clements, June, Bowermaster, Rebecca, Liu, Wen-Wei, Barnes, Michael, Alberts, Steven R, Shanmugam, Kandavel, Sinicrope, Frank A

“…Colorectal cancers with deficient DNA mismatch repair (dMMR) are presumed to uniformly have dense lymphocytic infiltration that underlies their favorable…”
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Immune Marker Spatial Distribution and Clinical Outcome after PD-1 Blockade in Mismatch Repair-deficient, Advanced Colorectal Carcinomas by Saberzadeh-Ardestani, Bahar, Graham, Rondell P, McMahon, Sara, Ahanonu, Eze, Shi, Qian, Williams, Crystal, Hubbard, Antony, Zhang, Wenjun, Muranyi, Andrea, Yan, Dongyao, Jin, Zhaohui, Shanmugam, Kandavel, Sinicrope, Frank A

“…Targeting the programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) interaction has led to durable responses in fewer than half of…”
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Identification of the Endogenous Smooth Muscle Myosin Phosphatase-Associated Kinase by MacDonald, Justin A., Borman, Meredith A., Murányi, Andrea, Somlyo, Avril V., Hartshorne, David J., Timothy A. J. Haystead

“…Ca2+ sensitization of smooth muscle contraction involves inhibition of myosin light chain phosphatase (SMPP-1M) and enhanced myosin light chain…”
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Evaluation of CD3 and CD8 T-Cell Immunohistochemistry for Prognostication and Prediction of Benefit From Adjuvant Chemotherapy in Early-Stage Colorectal Cancer Within the QUASAR Trial by Williams, Christopher J M, Gray, Richard, Hills, Robert K, Shires, Michael, Zhang, Liping, Zhao, Zuo, Gardner, Tracie, Sapanara, Nancy, Xu, Xiao-Meng, Bai, Isaac, Yan, Dongyao, Muranyi, Andrea, Dance, Sarah, Aghaei, Faranak, Hemmings, Gemma, Hale, Michael, Kurkure, Uday, Guetter, Christoph, Richman, Susan D, Hutchins, Gordon, Seligmann, Jenny F, West, Nicholas P, Singh, Shalini, Shanmugam, Kandavel, Quirke, Philip

“…High densities of tumor infiltrating CD3 and CD8 T-cells are associated with superior prognosis in colorectal cancer (CRC). Their value as predictors of…”
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GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis by Lopez-Sanchez, Inmaculada, Dunkel, Ying, Roh, Yoon-Seok, Mittal, Yash, De Minicis, Samuele, Muranyi, Andrea, Singh, Shalini, Shanmugam, Kandavel, Aroonsakool, Nakon, Murray, Fiona, Ho, Samuel B., Seki, Ekihiro, Brenner, David A., Ghosh, Pradipta

“…Progressive liver fibrosis is characterized by the deposition of collagen by activated hepatic stellate cells (HSCs). Activation of HSCs is a multiple…”
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Artificial intelligence-assisted immunohistochemical (IHC) evaluation of tumor amphiregulin (AREG) and epiregulin (EREG) expression as a combined predictive biomarker for panitumumab (Pan) therapy benefit in RAS wild-type (wt) metastatic colorectal cancer (mCRC): Analysis within the phase III PICCOLO trial by Williams, Christopher, Seligmann, Jenny F., Guetter, Christoph, Zhang, Liping, Yan, Dongyao, Muranyi, Andrea, Bai, Isaac, Singh, Shalini, Elliott, Faye, Shires, Mike, Richman, Susan, West, Nicholas, Barrett, Jenny, Seymour, Matthew T., Quirke, Philip, Shanmugam, Kandavel

“…Abstract only 111 Background: High tumor mRNA levels of the EGFR ligands, AREG and EREG are associated with anti-EGFR agent response in patients (pts) with…”
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Glyoxalase 1 Expression as a Novel Diagnostic Marker of High-Grade Prostatic Intraepithelial Neoplasia in Prostate Cancer by Rounds, Liliana, Nagle, Ray B, Muranyi, Andrea, Jandova, Jana, Gill, Scott, Vela, Elizabeth, Wondrak, Georg T

“…Glyoxalase 1 (GLO1) is an enzyme involved in the detoxification of methylglyoxal (MG), a reactive oncometabolite formed in the context of energy metabolism as…”
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Intratumoral CD3 + and CD8 + T-cell densities in patients with deficient DNA mismatch repair (dMMR) metastatic colorectal cancer (mCRC) receiving programmed death-1 (PD-1) blockade by Chakrabarti, Sakti, Huebner, Lucas J., Finnes, Heidi Diann, Muranyi, Andrea, Singh, Shalini, Clements, June, McWilliams, Robert R., Hubbard, Joleen Marie, Shanmugam, Kandavel, Sinicrope, Frank A.

“…Abstract only 3532 Background: Colorectal cancer with dMMR display heterogeneity in the extent of intratumoral T-cell infiltration which may explain their…”
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Associations between AI-Assisted Tumor Amphiregulin and Epiregulin IHC and Outcomes from Anti-EGFR Therapy in the Routine Management of Metastatic Colorectal Cancer by Williams, Christopher J M, Elliott, Faye, Sapanara, Nancy, Aghaei, Faranak, Zhang, Liping, Muranyi, Andrea, Yan, Dongyao, Bai, Isaac, Zhao, Zuo, Shires, Michael, Wood, Henry M, Richman, Susan D, Hemmings, Gemma, Hale, Michael, Bottomley, Daniel, Galvin, Leanne, Cartlidge, Caroline, Dance, Sarah, Bacon, Chris M, Mansfield, Laura, Young-Zvandasara, Kathe, Sudan, Ajay, Lambert, Katy, Bibby, Irena, Coupland, Sarah E, Montazeri, Amir, Kipling, Natalie, Hughes, Kathryn, Cross, Simon S, Dewdney, Alice, Pheasey, Leanne, Leng, Cathryn, Gochera, Tatenda, Mangham, D Chas, Saunders, Mark, Pritchard, Martin, Stott, Helen, Mukherjee, Abhik, Ilyas, Mohammad, Silverman, Rafael, Hyland, Georgina, Sculthorpe, Declan, Thornton, Kirsty, Gould, Imogen, O'Callaghan, Ann, Brown, Nicholas, Turnbull, Samantha, Shaw, Lisa, Seymour, Matthew T, West, Nicholas P, Seligmann, Jenny F, Singh, Shalini, Shanmugam, Kandavel, Quirke, Philip

“…High tumor production of the EGFR ligands, amphiregulin (AREG) and epiregulin (EREG), predicted benefit from anti-EGFR therapy for metastatic colorectal cancer…”
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Artificial Intelligence-Assisted Amphiregulin and Epiregulin IHC Predicts Panitumumab Benefit in RAS Wild-Type Metastatic Colorectal Cancer by Williams, Christopher J M, Seligmann, Jenny F, Elliott, Faye, Shires, Michael, Richman, Susan D, Brown, Sarah, Zhang, Liping, Singh, Shalini, Pugh, Judith, Xu, Xiao-Meng, Muranyi, Andrea, Guetter, Christoph, Lorsakul, Auranuch, Kurkure, Uday, Zhao, Zuo, Martin, Jim, Wang, Xingwei, Nguyen, Kien, Liu, Wen-Wei, Yan, Dongyao, West, Nicholas P, Barrett, Jennifer H, Barnes, Michael, Bai, Isaac, Seymour, Matthew T, Quirke, Philip, Shanmugam, Kandavel

“…High tumor mRNA levels of the EGFR ligands amphiregulin (AREG) and epiregulin (EREG) are associated with anti-EGFR agent response in metastatic colorectal…”
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Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase by Murányi, Andrea, MacDonald, Justin A, Deng, Jing Ti, Wilson, David P, Haystead, Timothy A J, Walsh, Michael P, Erdodi, Ferenc, Kiss, Eniko, Wu, Yue, Hartshorne, David J

“…A mechanism proposed for regulation of myosin phosphatase (MP) activity is phosphorylation of the myosin phosphatase target subunit (MYPT1). Integrin-linked…”
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Assessment of MYC/PTEN Status by Gene-Protein Assay in Grade Group 2 Prostate Biopsies by Salles, Daniela C., Vidotto, Thiago, Faisal, Farzana A., Tosoian, Jeffrey J., Guedes, Liana B., Muranyi, Andrea, Bai, Isaac, Singh, Shalini, Yan, Dongyao, Shanmugam, Kandavel, Lotan, Tamara L.

“…This study leveraged a gene-protein assay to assess MYC and PTEN status at prostate cancer biopsy and examined the association with adverse outcomes after…”
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Inter-tumoral heterogeneity of CD3+ and CD8+ T-cell densities in the microenvironment of DNA mismatch repair-deficient colon cancers: implications for prognosis by Yoon, Harry H., Shi, Qian, Heying, Erica N., Muranyi, Andrea, Bredno, Joerg, Ough, Faith, Djalilvand, Azita, Clements, June, Bowermaster, Rebecca, Liu, Wen-Wei, Barnes, Michael, Alberts, Steven R., Shanmugam, Kandavel, Sinicrope, Frank A.

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