Search Results - "Muralidharan, Bhavana"

Regulation of chromatin accessibility and gene expression in the developing hippocampal primordium by LIM-HD transcription factor LHX2 by Suresh, Varun, Muralidharan, Bhavana, Pradhan, Saurabh J, Bose, Mahima, D'Souza, Leora, Parichha, Arpan, Reddy, Puli Chandramouli, Galande, Sanjeev, Tole, Shubha

“…In the mammalian cerebral cortex, the hippocampal primordium (Hcp) occupies a discrete position in the dorsal telencephalic neuroepithelium adjacent to the…”
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Dmrt5, a Novel Neurogenic Factor, Reciprocally Regulates Lhx2 to Control the Neuron-Glia Cell-Fate Switch in the Developing Hippocampus by Muralidharan, Bhavana, Keruzore, Marc, Pradhan, Saurabh J, Roy, Basabdatta, Shetty, Ashwin S, Kinare, Veena, D'Souza, Leora, Maheshwari, Upasana, Karmodiya, Krishanpal, Suresh, Agasthya, Galande, Sanjeev, Bellefroid, Eric J, Tole, Shubha

“…Regulation of the neuron-glia cell-fate switch is a critical step in the development of the CNS. Previously, we demonstrated that Lhx2 is a necessary and…”
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Lhx2 regulates a cortex-specific mechanism for barrel formation by Shetty, Ashwin S, Godbole, Geeta, Maheshwari, Upasana, Padmanabhan, Hari, Chaudhary, Rahul, Muralidharan, Bhavana, Hou, Pei-Shan, Monuki, Edwin S, Kuo, Hung-Chih, Rema, V, Tole, Shubha

“…LIM homeodomain transcription factors are critical regulators of early development in multiple systems but have yet to be examined for a role in circuit…”
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Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus by Subramanian, Lakshmi, Sarkar, Anindita, Shetty, Ashwin S, Muralidharan, Bhavana, Padmanabhan, Hari, Piper, Michael, Monuki, Edwin S, Bach, Ingolf, Gronostajski, Richard M, Richards, Linda J, Tole, Shubha

“…The sequential production of neurons and astrocytes from neuroepithelial precursors is a fundamental feature of central nervous system development. We report…”
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Glucose-stimulated Translation Regulation of Insulin by the 5′ UTR-binding Proteins by Kulkarni, Shardul D., Muralidharan, Bhavana, Panda, Amaresh C., Bakthavachalu, Baskar, Vindu, Arya, Seshadri, Vasudevan

“…Insulin is the key regulator of glucose homeostasis in mammals, and glucose-stimulated insulin biosynthesis is essential for maintaining glucose levels in a…”
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A minimal element in 5′UTR of insulin mRNA mediates its translational regulation by glucose by Muralidharan, Bhavana, Bakthavachalu, Baskar, Pathak, Anuj, Seshadri, Vasudevan

“…Glucose induced translation of insulin in pancreatic beta cells is mediated by the 5′UTR of insulin mRNA. We determined the minimal sequence/structure in the…”
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Understanding brain development - Indian researchers' past, present and growing contribution by Muralidharan, Bhavana

“…The brain is the seat of all higher-order functions in the body. Brain development and the vast array of neurons and glia it produces is a baffling mystery to…”
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Novel splice variant of mouse insulin2 mRNA: Implications for insulin expression by Panda, Amaresh C., Kulkarni, Shardul D., Muralidharan, Bhavana, Bakthavachalu, Baskar, Seshadri, Vasudevan

“…Insulin is a secreted peptide that controls glucose homeostasis in mammals, and insulin biosynthesis is regulated by glucose at many levels. Rodent insulin is…”
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An Efficient System for Gene Perturbation in Embryonic Hippocampal Progenitors Using Ex Vivo Electroporation Followed by In Vitro Dissociated Cell Culture by Muralidharan, Bhavana, D’Souza, Leora, Tole, Shubha

“…We established an efficient cell culture assay that permits combinatorial genetic perturbations in hippocampal progenitors to examine cell-autonomous…”
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Chromatin remodelling complexes in cerebral cortex development and neurodevelopmental disorders by D'Souza, Leora, Channakkar, Asha S, Muralidharan, Bhavana

“…The diverse number of neurons in the cerebral cortex are generated during development by neural stem cells lining the ventricle, and they continue maturing…”
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LSD1 Regulates Neurogenesis in Human Neural Stem Cells Through the Repression of Human-Enriched Extracellular Matrix and Cell Adhesion Genes by Channakkar, Asha S, D'Souza, Leora, Kumar, Aparajita, Kalia, Kishan, Prabhu, Srilekha, Phalnikar, Kruttika, Reddy, Puli Chandramouli, Muralidharan, Bhavana

“…Neurogenesis begins with neural stem cells undergoing symmetric proliferative divisions to expand and then switching to asymmetric differentiative divisions to…”
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An evolutionarily conserved Lhx2-Ldb1 interaction regulates the acquisition of hippocampal cell fate and regional identity by Kinare, Veena, Iyer, Archana, Padmanabhan, Hari, Godbole, Geeta, Khan, Tooba, Khatri, Zeba, Maheshwari, Upasana, Muralidharan, Bhavana, Tole, Shubha

“…The protein co-factor Ldb1 regulates cell fate specification by interacting with LIM-homeodomain (LIM-HD) proteins in a tetrameric complex consisting of an…”
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Relax, Don’t RAN Translate It by Wilson, Katherine M., Muralidharan, Bhavana, Isaacs, Adrian M.

“…The (GGGGCC)n repeat expansion in C9orf72, which is the most common cause of frontotemporal dementia and amyotrophic lateral sclerosis, is translated through…”
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Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown by Clayton, Emma L, Milioto, Carmelo, Muralidharan, Bhavana, Norona, Frances E, Edgar, James R, Soriano, Armand, Jafar-nejad, Paymaan, Rigo, Frank, Collinge, John, Isaacs, Adrian M

“…See Bechek and Gitler (doi:10.1093/brain/awy294) for a scientific commentary on this article. Mutations in the endosome-associated protein CHMP2B cause…”
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LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11 by Muralidharan, Bhavana, Khatri, Zeba, Maheshwari, Upasana, Gupta, Ritika, Roy, Basabdatta, Pradhan, Saurabh J, Karmodiya, Krishanpal, Padmanabhan, Hari, Shetty, Ashwin S, Balaji, Chinthapalli, Kolthur-Seetharam, Ullas, Macklis, Jeffrey D, Galande, Sanjeev, Tole, Shubha

“…In the developing cerebral cortex, sequential transcriptional programs take neuroepithelial cells from proliferating progenitors to differentiated neurons with…”
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Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder by Phalnikar, Kruttika, Srividya, M, Mythri, S V, Vasavi, N S, Ganguly, Archisha, Kumar, Aparajita, S, Padmaja, Kalia, Kishan, Mishra, Srishti S, Dhanya, Sreeja Kumari, Paul, Pradip, Holla, Bharath, Ganesh, Suhas, Reddy, Puli Chandramouli, Sud, Reeteka, Viswanath, Biju, Muralidharan, Bhavana

“…Bipolar disorder (BD) is a severe mental illness that can result from neurodevelopmental aberrations, particularly in familial BD, which may include causative…”
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LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11 by Muralidharan, Bhavana, Khatri, Zeba, Maheshwari, Upasana, Gupta, Ritika, Roy, Basabdatta, Pradhan, Saurabh J., Karmodiya, Krishanpal, Padmanabhan, Hari, Shetty, Ashwin S., Balaji, Chinthapalli, Kolthur-Seetharam, Ullas, Macklis, Jeffrey D., Galande, Sanjeev, Tole, Shubha

“…In the developing cerebral cortex, sequential transcriptional programs take neuroepithelial cells from proliferating progenitors to differentiated neurons with…”
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An evolutionarily conserved Lhx2-Ldb1 interaction regulates the acquisition of hippocampal cell fate and regional identity by Kinare, Veena, Iyer, Archana, Padmanabhan, Hari, Godbole, Geeta, Khan, Tooba, Khatri, Zeba, Maheshwari, Upasana, Muralidharan, Bhavana, Tole, Shubha

“…Protein cofactor Ldb1 regulates cell fate specification by interacting with LIM-homeodomain (LIM-HD) proteins in a tetrameric complex consisting of an LDB:LDB…”
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Lhx2 regulates a cortex-specific mechanism for barrel formation by Shetty, Ashwin S., Godbole, Geeta, Maheshwari, Upasana, Padmanabhan, Hari, Chaudhary, Rahul, Muralidharan, Bhavana, Hou, Pei-Shan, Monuki, Edwin S., Kuo, Hung-Chih, Rema, V., Tole, Shubha

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A minimal element in 5'UTR of insulin mRNA mediates its translational regulation by glucose by Muralidharan, Bhavana, Bakthavachalu, Baskar, Pathak, Anuj, Seshadri, Vasudevan

“…Glucose induced translation of insulin in pancreatic beta cells is mediated by the 5'UTR of insulin mRNA. We determined the minimal sequence/structure in the…”
Get full text