Formulation and evaluation of dextromethorphan hydrobromide sustained release tablets

Formulation and evaluation of dextromethorphan hydrobromide sustained release tablets

Sustained release (SR) matrix tablets of dextromethorphan hydrobromide were prepared by wet granulation using hydroxypropyl methyl cellulose (HPMC-K-100 CR) as the hydrophilic rate controlling polymer. The effect of the concentration of the polymer and different fillers on the in vitro drug release...

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Bibliographic Details
Published in:Drug delivery Vol. 15; no. 7; p. 429
Main Authors: Meyyanathan, Subramania Nainar, Rajan, Sekar, Muralidaharan, Selvadurai, Siddaiah, Mahesh Kumar, Krishnaraj, Kaliaperumal, Suresh, Bhojraj
Format: Journal Article
Language:English
Published: England 01-01-2008
Subjects:
Adult
Antitussive Agents - administration & dosage
Antitussive Agents - blood
Antitussive Agents - pharmacokinetics
Biological Availability
Chromatography, High Pressure Liquid
Cross-Over Studies
Delayed-Action Preparations
Dextromethorphan - administration & dosage
Dextromethorphan - blood
Dextromethorphan - pharmacokinetics
Drug Compounding
Drug Stability
Excipients - chemistry
Humans
Hypromellose Derivatives
Kinetics
Male
Methylcellulose - analogs & derivatives
Methylcellulose - chemistry
Tablets
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Summary:Sustained release (SR) matrix tablets of dextromethorphan hydrobromide were prepared by wet granulation using hydroxypropyl methyl cellulose (HPMC-K-100 CR) as the hydrophilic rate controlling polymer. The effect of the concentration of the polymer and different fillers on the in vitro drug release rate was studied. The studies indicated that the drug release can be modulated by varying the concentration of the polymer and the fillers. A complete cross-over bioavailability study of the optimized formulation of the developed sustained tablets and marketed immediate release tablets was performed on six healthy male volunteers. The extent of absorption of drug from the SR tablets was significantly higher than that for the marketed dextromethorphan hydrobromide tablet because of lower elimination rate and longer half-life.
ISSN:1521-0464
DOI:10.1080/10717540802035301