Search Results - "Murakoshi, Maki"

Sodium-Glucose Cotransporter-2 Inhibitors-Miracle Drugs for the Treatment of Chronic Kidney Disease Irrespective of the Diabetes Status: Lessons from the Dedicated Kidney Disease-Focused CREDENCE and DAPA-CKD Trials by Gohda, Tomohito, Murakoshi, Maki

“…Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease (CKD) and end-stage kidney disease worldwide. In Japan, the proportion of new…”
Get full text

Circulating Tumor Necrosis Factor Receptors: A Potential Biomarker for the Progression of Diabetic Kidney Disease by Murakoshi, Maki, Gohda, Tomohito, Suzuki, Yusuke

“…Despite considerable advancements in medicine, the optimal treatment for chronic kidney disease (CKD), especially diabetic kidney disease (DKD), remains a…”
Get full text

Circulating tumor necrosis factor receptors are associated with mortality and disease severity in COVID-19 patients by Gohda, Tomohito, Murakoshi, Maki, Suzuki, Yusuke, Hiki, Makoto, Naito, Toshio, Takahashi, Kazuhisa, Tabe, Yoko

“…Background Although hyperinflammatory response influences the severity of coronavirus disease 2019 (COVID-19), little has been reported about the utility of…”
Get full text

Differential organ-specific inflammatory response to progranulin in high-fat diet-fed mice by Murakoshi, Maki, Gohda, Tomohito, Adachi, Eri, Ichikawa, Saki, Hagiwara, Shinji, Suzuki, Yusuke

“…Progranulin (PGRN) has been reported to bind tumor necrosis factor (TNF) receptor and to inhibit TNFα signaling. We evaluated the effect of augmentation of…”
Get full text

Circulating tumor necrosis factor receptors are associated with mortality and disease severity in COVID-19 patients by Tomohito Gohda, Maki Murakoshi, Yusuke Suzuki, Makoto Hiki, Toshio Naito, Kazuhisa Takahashi, Yoko Tabe

“…Background Although hyperinflammatory response influences the severity of coronavirus disease 2019 (COVID-19), little has been reported about the utility of…”
Get full text

Potential of Modulating Aldosterone Signaling and Mineralocorticoid Receptor with microRNAs to Attenuate Diabetic Kidney Disease by Hagiwara, Shinji, Gohda, Tomohito, Kantharidis, Phillip, Okabe, Jun, Murakoshi, Maki, Suzuki, Yusuke

“…Diabetic Kidney Disease (DKD) is a significant complication of diabetes and primary cause of end-stage renal disease globally. The exact mechanisms underlying…”
Get full text

Gut Microbiome and Microbiome-Derived Metabolites in Patients with End-Stage Kidney Disease by Koshida, Takeo, Gohda, Tomohito, Sugimoto, Takuya, Asahara, Takashi, Asao, Rin, Ohsawa, Isao, Gotoh, Hiromichi, Murakoshi, Maki, Suzuki, Yusuke, Yamashiro, Yuichiro

“…The composition of the gut microbiome is altered in patients with chronic kidney disease (CKD). Dysbiosis leads to decreased levels of stool organic acids…”
Get full text

Circulating TNF receptor levels are associated with estimated glomerular filtration rate even in healthy individuals with normal kidney function by Gohda, Tomohito, Murakoshi, Maki, Shibata, Terumi, Suzuki, Yusuke, Takemura, Hiroyuki, Tsuchiya, Koji, Okada, Tomoki, Wakita, Mitsuru, Horiuchi, Yuki, Tabe, Yoko, Kamei, Nozomu

“…The association between serum tumor necrosis factor receptor (TNFRs: TNFR1, TNFR2) levels and estimated glomerular filtration rate (eGFR) observed in patients…”
Get full text

Circulating kidney injury molecule‐1 as a biomarker of renal parameters in diabetic kidney disease by Gohda, Tomohito, Kamei, Nozomu, Koshida, Takeo, Kubota, Mitsunobu, Tanaka, Kanako, Yamashita, Yoshinori, Adachi, Eri, Ichikawa, Saki, Murakoshi, Maki, Ueda, Seiji, Suzuki, Yusuke

“…Aims/Introduction Urinary kidney injury molecule‐1 (KIM‐1) has been associated with proximal tubular damage in human and animal studies. Although it has been…”
Get full text

Association between circulating tumor necrosis factor-related biomarkers and estimated glomerular filtration rate in type 2 diabetes by Kamei, Nozomu, Yamashita, Mami, Nishizaki, Yuji, Yanagisawa, Naotake, Nojiri, Shuko, Tanaka, Kanako, Yamashita, Yoshinori, Shibata, Terumi, Murakoshi, Maki, Suzuki, Yusuke, Gohda, Tomohito

“…Chronic inflammation plays a crucial role in the development/progression of diabetic kidney disease. The involvement of tumor necrosis factor (TNF)-related…”
Get full text

Clinical predictive biomarkers for normoalbuminuric diabetic kidney disease by Gohda, Tomohito, Nishizaki, Yuji, Murakoshi, Maki, Nojiri, Shuko, Yanagisawa, Naotake, Shibata, Terumi, Yamashita, Mami, Tanaka, Kanako, Yamashita, Yoshinori, Suzuki, Yusuke, Kamei, Nozomu

“…A portion of patients with diabetes mellitus follow the progression of a non-albuminuria-based pathway; i.e., normoalbuminuric diabetic kidney disease…”
Get full text

Progranulin deficiency attenuates tubulointerstitial injury in a mouse unilateral ureteral obstruction model by Adachi, Eri, Murakoshi, Maki, Shibata, Terumi, Shimozawa, Kenta, Sakuma, Hiroko, Kishida, Chiaki, Gohda, Tomohito, Suzuki, Yusuke

“…Progranulin (PGRN) may have two opposing effects—inflammation and anti-inflammation—in different diseases. Although previous studies have reported that PGRN is…”
Get full text

Progranulin and Its Receptor Predict Kidney Function Decline in Patients With Type 2 Diabetes by Murakoshi, Maki, Gohda, Tomohito, Sakuma, Hiroko, Shibata, Terumi, Adachi, Eri, Kishida, Chiaki, Ichikawa, Saki, Koshida, Takeo, Kamei, Nozomu, Suzuki, Yusuke

“…Progranulin (PGRN), a growth factor, is abundantly expressed in a broad range of tissues and cell types with pleiotropic functions including inflammation,…”
Get full text

Fractional excretion of tumor necrosis factor receptor 1 and 2 in patients with type 2 diabetes and normal renal function by Gohda, Tomohito, Kamei, Nozomu, Kubota, Mitsunobu, Tanaka, Kanako, Yamashita, Yoshinori, Sakuma, Hiroko, Kishida, Chiaki, Adachi, Eri, Koshida, Takeo, Murakoshi, Maki, Hagiwara, Shinji, Funabiki, Kazuhiko, Ueda, Seiji, Suzuki, Yusuke

“…Aims/Introduction Increased concentrations of serum tumor necrosis factor (TNF) receptors (TNFRs; TNFR1 and TNFR2) are positively associated with the urinary…”
Get full text

Development of an In-House EphA2 ELISA for Human Serum and Measurement of Circulating Levels of EphA2 in Hypertensive Patients with Renal Dysfunction by Murakoshi, Maki, Iwasawa, Takumi, Koshida, Takeo, Suzuki, Yusuke, Gohda, Tomohito, Kato, Kazunori

“…Identifying novel biomarkers of kidney function in patients with chronic kidney disease (CKD) has strong clinical value as current measures have limitations…”
Get full text

Aspartic acid supplementation ameliorates symptoms of diabetic kidney disease in mice by Ichikawa, Saki, Gohda, Tomohito, Murakoshi, Maki, Li, Zi, Adachi, Eri, Koshida, Takeo, Suzuki, Yusuke

“…Diabetic kidney disease (DKD) is among the most common and serious complications of both type 1 and type 2 diabetes. In this study, we used KK/Ta‐Ins2Akita…”
Get full text

Effect of tonsillectomy with steroid pulse therapy on circulating tumor necrosis factor receptors 1 and 2 in IgA nephropathy by Murakoshi, Maki, Gohda, Tomohito, Sonoda, Yuji, Suzuki, Hitoshi, Tomino, Yasuhiko, Horikoshi, Satoshi, Suzuki, Yusuke

“…Background High circulating levels of soluble tumor necrosis factor receptors (TNFRs: TNFR1, TNFR2) predict renal function decline in a variety of kidney…”
Get full text

The sodium–glucose cotransporter 2 inhibitor tofogliflozin prevents diabetic kidney disease progression in type 2 diabetic mice by Li, Zi, Murakoshi, Maki, Ichikawa, Saki, Koshida, Takeo, Adachi, Eri, Suzuki, Chigure, Ueda, Seiji, Gohda, Tomohito, Suzuki, Yusuke

“…Tofogliflozin may prevent glomerular (enlarged mesangial area, foot process effacement, podocyte loss) and tubulointerstitial damage (increased expression of…”
Get full text

Associations between circulating levels of FABP4 and TNF receptors are more evident in patients with type 2 diabetes mellitus than in patients with type 1 diabetes mellitus by Tanaka, Marenao, Gohda, Tomohito, Kamei, Nozomu, Murakoshi, Maki, Sato, Tatsuya, Kubota, Mitsunobu, Sanuki, Michiyoshi, Ishiwata, Erika, Endo, Keisuke, Suzuki, Yusuke, Furuhashi, Masato

“…Fatty acid-binding protein 4 (FABP4) is an adipokine that plays significant roles in the development of insulin resistance and atherosclerosis. High levels of…”
Get full text

Effect of Zinc Acetate Dihydrate (NobelzinR) Treatment on Anemia and Taste Disorders in Patients with Chronic Kidney Disease with Hypozincemia by Sato, Daisuke, Gohda, Tomohito, Kihara, Masao, Kanaguchi, Yasuhiko, Kobayashi, Takashi, Mano, Satoshi, Sasaki, Yu, Nohara, Nao, Murakoshi, Maki, Nakata, Junichiro, Suzuki, Hitoshi, Ueda, Seiji, Horikoshi, Satoshi, Suzuki, Yusuke

“…Some patients with chronic kidney disease (CKD) receiving hemodialysis develop erythropoietin-resistant anemia, possibly due to zinc deficiency. The frequency…”
Get full text