Search Results - "Murakami‐Murofushi, Kimiko"

Saturated fatty acid is a principal cause of anxiety-like behavior in diet-induced obese rats in relation to serum lysophosphatidyl choline level by Nakajima, Shingo, Fukasawa, Keiko, Gotoh, Mari, Murakami-Murofushi, Kimiko, Kunugi, Hiroshi

“…Background Obesity is considered to be a risk factor for neurodegenerative- and psychiatric- diseases including Alzheimer’s disease, schizophrenia, and…”
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2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition by Fukasawa, Keiko, Gotoh, Mari, Uwamizu, Akiharu, Hirokawa, Takatsugu, Ishikawa, Masaki, Shimizu, Yoshibumi, Yamamoto, Shinji, Iwasa, Kensuke, Yoshikawa, Keisuke, Aoki, Junken, Murakami-Murofushi, Kimiko

“…Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator that, along with its chemically stabilized analogue 2-carba-cyclic phosphatidic…”
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Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathway by Sakai, Kazuko, Yokote, Hideyuki, Murakami‐Murofushi, Kimiko, Tamura, Tomohide, Saijo, Nagahiro, Nishio, Kazuto

“…A humanized anti‐HER2 monoclonal antibody pertuzumab (Omnitarg, 2C4), binding to a different HER2 epitope than trastuzumab, is known as an inhibitor of…”
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LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model by Tsukahara, Ryoko, Yamamoto, Shinji, Yoshikawa, Keisuke, Gotoh, Mari, Tsukahara, Tamotsu, Neyama, Hiroyuki, Ishii, Satoshi, Akahoshi, Noriyuki, Yanagida, Keisuke, Sumida, Hayakazu, Araki, Masatake, Araki, Kimi, Yamamura, Ken-ichi, Murakami-Murofushi, Kimiko, Ueda, Hiroshi

“…Lysophosphatidic acid (LPA) and LPA1 receptor signaling play a crucial role in the initiation of peripheral nerve injury-induced neuropathic pain through the…”
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Ionizing radiation, inflammation, and their interactions in colon carcinogenesis in Mlh1‐deficient mice by Morioka, Takamitsu, Miyoshi‐Imamura, Tomoko, Blyth, Benjamin J., Kaminishi, Mutsumi, Kokubo, Toshiaki, Nishimura, Mayumi, Kito, Seiji, Tokairin, Yutaka, Tani, Shusuke, Murakami‐Murofushi, Kimiko, Yoshimi, Naoki, Shimada, Yoshiya, Kakinuma, Shizuko

“…Genetic, physiological and environmental factors are implicated in colorectal carcinogenesis. Mutations in the mutL homolog 1 (MLH1) gene, one of the DNA…”
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Age-related changes in cyclic phosphatidic acid-induced hyaluronic acid synthesis in human fibroblasts by Sano, Katsura, Gotoh, Mari, Dodo, Kyoko, Tajima, Noriaki, Shimizu, Yoshibumi, Murakami-Murofushi, Kimiko

“…Hyaluronic acid is a major component of the extracellular matrix, which is important for skin hydration. As aging brings skin dehydration, we aimed to clarify…”
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Cyclic Phosphatidic Acid Relieves Osteoarthritis Symptoms by Gotoh, Mari, Nagano, Aya, Tsukahara, Ryoko, Murofushi, Hiromu, Morohoshi, Toshiro, Otsuka, Kazuyuki, Murakami-Murofushi, Kimiko

“…Background: Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator with a unique cyclic phosphate ring at the sn-2 and sn-3 positions of…”
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Oleic acid is a potent inducer for lipid droplet accumulation through its esterification to glycerol by diacylglycerol acyltransferase in primary cortical astrocytes by Nakajima, Shingo, Gotoh, Mari, Fukasawa, Keiko, Murakami-Murofushi, Kimiko, Kunugi, Hiroshi

“…•Oleic acid strongly induced astrocytic lipid droplet (LD) accumulation.•Lipid composition of cellular LDs reflected to extracellular fatty acids.•Inhibition…”
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Antinociceptive Effect of Cyclic Phosphatidic Acid and Its Derivative on Animal Models of Acute and Chronic Pain by Kakiuchi, Yasutaka, Nagai, Jun, Gotoh, Mari, Hotta, Harumi, Murofushi, Hiromu, Ogawa, Tomoyo, Ueda, Hiroshi, Murakami-Murofushi, Kimiko

“…Background: Cyclic phosphatidic acid (cPA) is a structural analog of lysophosphatidic acid (LPA), but possesses different biological functions, such as the…”
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2-carba-cyclic phosphatidic acid modulates astrocyte-to-microglia communication and influences microglial polarization towards an anti-inflammatory phenotype by Takei, Rino, Nakashima, Mari, Gotoh, Mari, Endo, Misaki, Hashimoto, Kei, Miyamoto, Yasunori, Murakami-Murofushi, Kimiko

“…[Display omitted] •Astrocyte conditioned media (2ccPA-ACM) was collected from 2ccPA-treated astrocytes.•2ccPA-ACM decreased the ratio of M1 phenotype…”
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Cyclic phosphatidic acid elicits neurotrophin‐like actions in embryonic hippocampal neurons by Fujiwara, Yuko, Sebök, Agnes, Meakin, Susan, Kobayashi, Tetsuyuki, Murakami‐Murofushi, Kimiko, Tigyi, Gabor

“…Cyclic phosphatidic acid (cPA; 1‐acyl‐sn‐glycerol‐2,3‐cyclic phosphate) is an analog of the growth factor‐like phospholipid mediator lysophosphatidic acid…”
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The neuroprotective function of 2-carba-cyclic phosphatidic acid: Implications for tenascin-C via astrocytes in traumatic brain injury by Nakashima, Mari, Gotoh, Mari, Hashimoto, Kei, Endo, Misaki, Murakami-Murofushi, Kimiko, Ikeshima-Kataoka, Hiroko, Miyamoto, Yasunori

“…We examined the mechanism how 2-carba-cyclic phosphatidic acid (2ccPA), a lipid mediator, regulates neuronal apoptosis in traumatic brain injury (TBI). First,…”
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Adenine nucleotide translocase 2, a putative target protein for 2-carba cyclic phosphatidic acid in microglial cells by Tsukahara, Tamotsu, Sahara, Yasuka, Ribeiro, Nigel, Tsukahara, Ryoko, Gotoh, Mari, Sakamoto, Satoshi, Handa, Hiroshi, Murakami-Murofushi, Kimiko

“…Lipid-protein interactions play essential roles in many biological phenomena. Lysophospholipid mediators, such as cyclic phosphatidic acid (cPA), have been…”
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Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease by Yamamoto, Shinji, Yamashina, Kota, Ishikawa, Masaki, Gotoh, Mari, Yagishita, Sosuke, Iwasa, Kensuke, Maruyama, Kei, Murakami-Murofushi, Kimiko, Yoshikawa, Keisuke

“…Multiple sclerosis is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by recurrent and progressive…”
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2-O-Carba-oleoyl cyclic phosphatidic acid induces glial proliferation through the activation of lysophosphatidic acid receptor by Nakajima, Shingo, Gotoh, Mari, Fukasawa, Keiko, Murofushi, Hiromu, Murakami-Murofushi, Kimiko

“…•2ccPA increased glial cell proliferation through the activation of LPA receptor.•2ccPA treatment enhanced cell survival against oxidative stress.•ERK pathway…”
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Cyclic phosphatidic acid and lysophosphatidic acid induce hyaluronic acid synthesis via CREB transcription factor regulation in human skin fibroblasts by Maeda-Sano, Katsura, Gotoh, Mari, Morohoshi, Toshiro, Someya, Takao, Murofushi, Hiromu, Murakami-Murofushi, Kimiko

“…Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator and an analog of the growth factor-like phospholipid lysophosphatidic acid (LPA)…”
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Protection of neuroblastoma Neuro2A cells from hypoxia-induced apoptosis by cyclic phosphatidic acid (cPA) by Gotoh, Mari, Sano-Maeda, Katsura, Murofushi, Hiromu, Murakami-Murofushi, Kimiko

“…Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator with a unique cyclic phosphate ring at the sn-2 and sn-3 positions of its…”
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Quantitative determination of cyclic phosphatidic acid and its carba analog in mouse organs and plasma using LC–MS/MS by Shimizu, Yoshibumi, Ishikawa, Masaki, Gotoh, Mari, Fukasawa, Keiko, Yamamoto, Shinji, Iwasa, Kensuke, Yoshikawa, Keisuke, Murakami-Murofushi, Kimiko

“…Cyclic phosphatidic acid (cPA), an analog of lysophosphatidic acid, is involved in the regulation of many cellular processes. A sensitive and specific method…”
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Attenuation by cyclic phosphatidic acid of peritoneal metastasis of azoxymethane‐induced intestinal cancers in Wistar rats by Ishihara, Ryu, Tatsuta, Masaharu, Iishi, Hiroyasu, Baba, Miyako, Uedo, Noriya, Higashino, Koji, Mukai, Mutsuko, Ishiguro, Shingo, Kobayashi, Susumu, Murakami‐Murofushi, Kimiko

“…The effect of cyclic phosphatidic acid, a unique analogue of lysophosphatidic acid, on the induction of bombesin‐enhanced peritoneal metastases from intestinal…”
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Release of Cyclic Phosphatidic Acid from Gelatin-based Hydrogels Inhibit Colon Cancer Cell Growth and Migration by Tsukahara, Tamotsu, Murakami-Murofushi, Kimiko

“…Microparticle and nanoparticle formulations are widely used to improve the bioavailability of low-solubility drugs and as vehicles for organ- and…”
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