Search Results - "Murakami, Shigekazu"

A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas by Murakami, Shigekazu, Nemazanyy, Ivan, White, Shannon M., Chen, Hengye, Nguyen, Chan D.K., Graham, Garrett T., Saur, Dieter, Pende, Mario, Yi, Chunling

“…Employing inducible genetically engineered and orthotopic mouse models, we demonstrate a key role for transcriptional regulator Yap in maintenance of…”
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SRY and OCT4 Are Required for the Acquisition of Cancer Stem Cell‐Like Properties and Are Potential Differentiation Therapy Targets by Murakami, Shigekazu, Ninomiya, Wataru, Sakamoto, Erina, Shibata, Tatsuhiro, Akiyama, Hirotada, Tashiro, Fumio

“…The acquisition of stemness is a hallmark of aggressive human hepatocellular carcinoma (hHCC). The stem cell marker OCT4 is frequently expressed in HCCs, and…”
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Spontaneously evolved progenitor niches escape Yap oncogene addiction in advanced pancreatic ductal adenocarcinomas by Murakami, Shigekazu, White, Shannon M., McIntosh, Alec T., Nguyen, Chan D. K., Yi, Chunling

“…Lineage plasticity has been proposed as a major source of intratumoral heterogeneity and therapeutic resistance. Here, by employing an inducible genetic…”
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PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer by Nguyen, Chan D.K., Colón-Emeric, Benjamín A., Murakami, Shigekazu, Shujath, Mia N.Y., Yi, Chunling

“…Pancreatic ductal adenocarcinoma (PDAC) carries a dismal prognosis due to therapeutic resistance. We show that PDAC cells undergo global epigenetic…”
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SGF29 and Sry pathway in hepatocarcinogenesis by Kurabe, Nobuya, Murakami, Shigekazu, Tashiro, Fumio

“…Deregulated c-Myc expression is a hallmark of many human cancers. We have recently identified a role of mammalian homolog of yeast…”
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The complex entanglement of Hippo-Yap/Taz signaling in tumor immunity by White, Shannon M., Murakami, Shigekazu, Yi, Chunling

“…The Hippo-Yap/Taz pathway, originally identified as a central developmental regulator of organ size, has been found perturbed in many types of human tumors,…”
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Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma by Murakami, S, Shahbazian, D, Surana, R, Zhang, W, Chen, H, Graham, G T, White, S M, Weiner, L M, Yi, C

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by a high degree of inflammation and profound immune suppression. Here we identify Yes-associated…”
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