Search Results - "Murai, Toshiyuki"

Cholesterol lowering: role in cancer prevention and treatment by Murai, Toshiyuki

“…The accumulation of cholesterol is a general feature of cancer tissue, and recent evidence suggests that cholesterol plays critical roles in the progression of…”
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Transmembrane signaling through single-spanning receptors modulated by phase separation at the cell surface by Murai, Toshiyuki

“…A wide variety of transmembrane signals are transduced by cell-surface receptors that activate intracellular signaling molecules. In particular, receptor…”
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The Chemopreventive Effects of Chlorogenic Acids, Phenolic Compounds in Coffee, against Inflammation, Cancer, and Neurological Diseases by Murai, Toshiyuki, Matsuda, Satoru

“…Coffee is one of the most widely consumed beverages, which has several effects on the human body. In particular, current evidence suggests that coffee…”
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The Role of Lipid Rafts in Cancer Cell Adhesion and Migration by Murai, Toshiyuki

“…Lipid rafts are cholesterol-enriched microdomains of the cell membrane and possess a highly dynamic nature. They have been involved in various cellular…”
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Lipid Raft-Mediated Regulation of Hyaluronan-CD44 Interactions in Inflammation and Cancer by Murai, Toshiyuki

“…Hyaluronan is a major component of the extracellular matrix and plays pivotal roles in inflammation and cancer. Hyaluronan oligomers are frequently found in…”
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Therapeutic Implications of Probiotics in the Gut Microbe-Modulated Neuroinflammation and Progression of Alzheimer's Disease by Murai, Toshiyuki, Matsuda, Satoru

“…Alzheimer's disease (AD) is characterized by the accumulation of specific proteins in the brain. A recent study revealed that manipulating gut microbiota (GM)…”
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Metabolic Reprogramming toward Aerobic Glycolysis and the Gut Microbiota Involved in the Brain Amyloid Pathology by Murai, Toshiyuki, Matsuda, Satoru

“…Alzheimer’s disease (AD) is characterized by the formation of senile plaques consisting of fibrillated amyloid-β (Aβ), dystrophic neurites, and the…”
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Pleiotropic Signaling by Reactive Oxygen Species Concerted with Dietary Phytochemicals and Microbial-Derived Metabolites as Potent Therapeutic Regulators of the Tumor Microenvironment by Murai, Toshiyuki, Matsuda, Satoru

“…The excessive generation of reactive oxygen species (ROS) plays a pivotal role in the pathogenesis of diseases. ROS are central to cellular redox regulation…”
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PI3K/AKT signaling mediated by G protein‑coupled receptors is involved in neurodegenerative Parkinson's disease (Review) by Nakano, Noriko, Matsuda, Satoru, Ichimura, Mayuko, Minami, Akari, Ogino, Mako, Murai, Toshiyuki, Kitagishi, Yasuko

“…Parkinson's disease (PD) is a common progressive and multifactorial neurodegenerative disease, characterized by the loss of midbrain dopaminergic neurons…”
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Fatty Acid Metabolites and the Tumor Microenvironment as Potent Regulators of Cancer Stem Cell Signaling by Murai, Toshiyuki, Matsuda, Satoru

“…Individual cancer cells are not equal but are organized into a cellular hierarchy in which only a rare few leukemia cells can self-renew in a manner…”
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Integrated Multimodal Omics and Dietary Approaches for the Management of Neurodegeneration by Murai, Toshiyuki, Matsuda, Satoru

“…Neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, are caused by a combination of multiple events that damage neuronal function…”
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Low Cholesterol Triggers Membrane Microdomain-dependent CD44 Shedding and Suppresses Tumor Cell Migration by Murai, Toshiyuki, Maruyama, Yuusuke, Mio, Kazuhiro, Nishiyama, Hidetoshi, Suga, Mitsuo, Sato, Chikara

“…CD44 is a cell surface adhesion molecule for hyaluronan and is implicated in tumor invasion and metastasis. Proteolytic cleavage of CD44 plays a critical role…”
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Editorial: Cell-Cell and Cell-Matrix Adhesion in Immunobiology and Cancer by Murai, Toshiyuki, Kawashima, Hiroto, Naor, David

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Reactive Oxygen Species, Superoxide Dimutases, and PTEN-p53-AKT-MDM2 Signaling Loop Network in Mesenchymal Stem/Stromal Cells Regulation by Matsuda, Satoru, Nakagawa, Yukie, Kitagishi, Yasuko, Nakanishi, Atsuko, Murai, Toshiyuki

“…Mesenchymal stromal/stem cells (MSCs) are multipotent cells that can differentiate to various specialized cells, which have the potential capacity to…”
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Effective PI3K modulators for improved therapy against malignant tumors and for neuroprotection of brain damage after tumor therapy (Review) by Matsuda, Satoru, Ichimura, Mayuko, Ogino, Mako, Nakano, Noriko, Minami, Akari, Murai, Toshiyuki, Kitagishi, Yasuko

“…Due to the key role in various cellular processes including cell proliferation and cell survival on many cell types, dysregulation of the PI3K/AKT pathway…”
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A novel inhibitory mechanism of MRTF-A/B on the ICAM-1 gene expression in vascular endothelial cells by Hayashi, Ken’ichiro, Murai, Toshiyuki, Oikawa, Hiroki, Masuda, Tomoyuki, Kimura, Kazuhiro, Muehlich, Susanne, Prywes, Ron, Morita, Tsuyoshi

“…The roles of myocardin-related transcription factor A (MRTF-A) and MRTF-B in vascular endothelial cells are not completely understood. Here, we found a novel…”
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Ultrastructural analysis of nanogold-labeled cell surface microvilli in liquid by atmospheric scanning electron microscopy and their relevance in cell adhesion by Murai, Toshiyuki, Sato, Mari, Nishiyama, Hidetoshi, Suga, Mitsuo, Sato, Chikara

“…The adhesion of leukocytes circulating in the blood to vascular endothelium is critical for their trafficking in the vasculature, and CD44 is an important cell…”
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Hyaluronan Oligosaccharides Induce CD44 Cleavage and Promote Cell Migration in CD44-expressing Tumor Cells by Sugahara, Kazuki N., Murai, Toshiyuki, Nishinakamura, Hitomi, Kawashima, Hiroto, Saya, Hideyuki, Miyasaka, Masayuki

“…CD44 is an adhesion molecule that serves as a cell surface receptor for several extracellular matrix components, including hyaluronan (HA). The proteolytic…”
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Tumor Cells Enhance Their Own CD44 Cleavage and Motility by Generating Hyaluronan Fragments by Sugahara, Kazuki N., Hirata, Takako, Hayasaka, Haruko, Stern, Robert, Murai, Toshiyuki, Miyasaka, Masayuki

“…Hyaluronan (HA) is an extracellular matrix glycosaminoglycan that interacts with cell-surface receptors, including CD44. Although HA usually exists as a high…”
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Binding of L-selectin to its vascular and extravascular ligands is differentially regulated by pH by Hirose, Mayumi, Matsumura, Ryuji, Sato, Kaori, Murai, Toshiyuki, Kawashima, Hiroto

“…[Display omitted] ► L-Selectin binding to vascular and extravascular ligands shows different pH optima. ► Optimal L-selectin-vascular ligand binding is…”
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