Search Results - "Munusamy, Shankar"

Renoprotective mechanisms of sodium‐glucose co‐transporter 2 (SGLT2) inhibitors against the progression of diabetic kidney disease by Ravindran, Sreenithya, Munusamy, Shankar

“…Sodium‐glucose co‐transporter 2 inhibitors (SGLT2‐Is) have emerged as a promising class of antidiabetic drugs with cardioprotective and renoprotective effects…”
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Nephroprotective Effects of Metformin in Diabetic Nephropathy by Ravindran, Sreenithya, Kuruvilla, Vinitha, Wilbur, Kerry, Munusamy, Shankar

“…Metformin, a well‐known anti‐diabetic agent, is very effective in lowering blood glucose in patients with type 2 diabetes with minimal side‐effects. Metformin…”
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Crosstalk Between Oxidative Stress and Endoplasmic Reticulum (ER) Stress in Endothelial Dysfunction and Aberrant Angiogenesis Associated With Diabetes: A Focus on the Protective Roles of Heme Oxygenase (HO)-1 by Maamoun, Hatem, Benameur, Tarek, Pintus, Gianfranco, Munusamy, Shankar, Agouni, Abdelali

“…Type-2 diabetes prevalence is continuing to rise worldwide due to physical inactivity and obesity epidemic. Diabetes and fluctuations of blood sugar are…”
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Metformin attenuates albumin‐induced alterations in renal tubular cells in vitro by Allouch, Soumaya, Munusamy, Shankar

“…Proteinuria (albuminuria) plays a crucial role in the etiology of chronic kidney disease (CKD) via alteration of multiple signaling pathways and cellular…”
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Smart Nanocarriers for the Delivery of Nucleic Acid‐Based Therapeutics: A Comprehensive Review by Ramasamy, Thiruganesh, Munusamy, Shankar, Ruttala, Hima Bindu, Kim, Jong Oh

“…Nucleic acid‐based therapies are promising therapeutics for the treatment of several systemic disorders, and they offer an exciting opportunity to address…”
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Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases by Gorin, Yves, Eid, Assaad, Eid, Ali H., Pasha, Mazhar, Munusamy, Shankar

“…Sestrin2 (SESN2), a highly conserved stress-inducible metabolic protein, is known to repress reactive oxygen species (ROS) and provide cytoprotection against…”
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Mitochondrial superoxide plays a crucial role in the development of mitochondrial dysfunction during high glucose exposure in rat renal proximal tubular cells by Munusamy, Shankar, MacMillan-Crow, Lee Ann

“…Diabetic nephropathy is the leading cause of end-stage renal disease in the United States. Despite several studies indicating a role for mitochondrial…”
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Microparticles as Potential Mediators of High Glucose-Induced Renal Cell Injury by Ravindran, Sreenithya, Pasha, Mazhar, Agouni, Abdelali, Munusamy, Shankar

“…Diabetic nephropathy (DN) is the most common cause of chronic kidney disease worldwide. Activation of signaling pathways such as the mammalian target of…”
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Aldose Reductase as a Drug Target for Treatment of Diabetic Nephropathy: Promises and Challenges by ElGamal, Heba, Munusamy, Shankar

“…Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes mellitus and the leading cause of end stage renal disease. One of…”
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Metformin Induces Different Responses in Clear Cell Renal Cell Carcinoma Caki Cell Lines by Pasha, Mazhar, Sivaraman, Siveen K, Frantz, Ronald, Agouni, Abdelali, Munusamy, Shankar

“…Clear cell renal cell carcinoma (ccRCC) is the most common and lethal form of urological cancer diagnosed globally. Mutations of the von Hippel-Lindau…”
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Protective effects of Empagliflozin against Transforming growth factor‐beta‐induced fibrosis in renal proximal tubular cells by Bayne, Sarah, Munusamy, Shankar

“…Background Chronic kidney disease (CKD) is the condition where the kidneys are unable to filter and clean the blood of waste properly. Hypertension, obesity,…”
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Alteration of renal respiratory Complex-III during experimental type-1 diabetes by Munusamy, Shankar, Saba, Hamida, Mitchell, Tanecia, Megyesi, Judit K, Brock, Robert W, Macmillan-Crow, Lee Ann

“…Diabetes has become the single most common cause for end-stage renal disease in the United States. It has been established that mitochondrial damage occurs…”
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Impact of Mnemonics and Analogies in a Biochemistry Course on Students' Knowledge, Retention, and Application by Iyer, Prema c., Munusamy, Shankar

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Mnemonics Improve Pharmacy Students' Knowledge Retention, Clinical Application, and Exam Performance in a PharmD Pharmacology Course by Munusamy, Shankar, Koenigsfeld, Carrie, Torry, Ronald

“…Background Students in healthcare professions taking pharmacology courses often feel challenged with learning and remembering crucial facts about medications,…”
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Nano drug delivery systems for antisense oligonucleotides (ASO) therapeutics by Ramasamy, Thiruganesh, Ruttala, Hima Bindu, Munusamy, Shankar, Chakraborty, Nilay, Kim, Jong Oh

“…Cancer, infectious diseases, and metabolic and hereditary genetic disorders are a global health burden affecting millions of people, with contemporary…”
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Metformin Protects Renal Tubular Cells Against Albumin‐Induced Alterations and Cellular Injury by Allouch, Soumaya, Munusamy, Shankar

“…Abstract only Introduction Proteinuria (or increased albumin excretion), a hallmark of chronic kidney disease (CKD), plays a critical role in the development…”
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Integrating Wellness Activities into Courses Promotes Pharmacy Students’ Resilience by Munusamy, Shankar, Nelson, Michael H., Torry, Ronald J.

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Renoprotective Effects of Low‐dose Metformin Treatment in a Mouse Model of Diabetic Kidney Disease by Munusamy, Shankar, Olstinske, Kayla, Karch, Christopher, Frantz, Ronald, Carnevale, Kevin

“…Background Diabetes mellitus (DM) affects more than 30 million people in the United States. About one‐third of DM patients develop diabetic kidney disease…”
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Myrtenal attenuates oxidative stress and inflammation in a rat model of streptozotocin-induced diabetes by Rathinam, Ayyasamy, Pari, Leelavinothan, Venkatesan, Manigandan, Munusamy, Shankar

“…The present study was aimed to investigate the effect of myrtenal on diabetes-associated oxidative stress, lipid peroxidation (LPO), and inflammation using a…”
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ANTI‐NEOPLASTIC EFFECTS OF METFORMIN AGAINST RENAL CLEAR CELL CARCINOMA by Munusamy, Shankar, Pasha, Mazhar, Agouni, Abdelali

“…Background and Objectives Renal clear cell carcinoma (RCCC) is the most common and lethal form of urological cancer diagnosed globally. Mutation of Von‐Hippel…”
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