Search Results - "Muntean, S"

Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli by Jin, Xingjian, Mohieldin, Ashraf M, Muntean, Brian S, Green, Jill A, Shah, Jagesh V, Mykytyn, Kirk, Nauli, Surya M

“…Primary cilia with a diameter of ~200 nm have been implicated in development and disease. Calcium signaling within a primary cilium has never been directly…”
Get full text

KCTD5 Forms Hetero-Oligomeric Complexes with Various Members of the KCTD Protein Family by Liao, Yini, Sloan, Douglas C, Widjaja, Josephine H, Muntean, Brian S

“…Potassium Channel Tetramerization Domain 5 (KCTD5) regulates diverse aspects of physiology, ranging from neuronal signaling to colorectal cancer. A key feature…”
Get full text

Allostatic Changes in the cAMP System Drive Opioid-Induced Adaptation in Striatal Dopamine Signaling by Muntean, Brian S., Dao, Maria T., Martemyanov, Kirill A.

“…Opioids are powerful addictive agents that alter dopaminergic influence on reward signaling in medium spiny neurons (MSNs) of the nucleus accumbens. Repeated…”
Get full text

NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control by Sutton, Laurie P, Muntean, Brian S, Ostrovskaya, Olga, Zucca, Stefano, Dao, Maria, Orlandi, Cesare, Song, Chenghui, Xie, Keqiang, Martemyanov, Kirill A

“…The striatum plays a fundamental role in motor learning and reward-related behaviors that are synergistically shaped by populations of D1 dopamine receptor…”
Get full text

Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits by Muntean, Brian S., Zucca, Stefano, MacMullen, Courtney M., Dao, Maria T., Johnston, Caitlin, Iwamoto, Hideki, Blakely, Randy D., Davis, Ronald L., Martemyanov, Kirill A.

“…Modulation of neuronal circuits is key to information processing in the brain. The majority of neuromodulators exert their effects by activating…”
Get full text

Orphan receptor GPR158 controls stress-induced depression by Sutton, Laurie P, Orlandi, Cesare, Song, Chenghui, Oh, Won Chan, Muntean, Brian S, Xie, Keqiang, Filippini, Alice, Xie, Xiangyang, Satterfield, Rachel, Yaeger, Jazmine D W, Renner, Kenneth J, Young, Jr, Samuel M, Xu, Baoji, Kwon, Hyungbae, Martemyanov, Kirill A

“…Stress can be a motivational force for decisive action and adapting to novel environment; whereas, exposure to chronic stress contributes to the development of…”
Get full text

Failure assessment of the shaft of a pumped storage unit by Negru, R., Muntean, S., Pasca, N., Marsavina, L.

“…ABSTRACTThe paper is focused on failure assessment of the shaft of a pumped storage unit. The shaft failure occurred during normal operation of the hydropower…”
Get full text

Molecular Deconvolution Platform to Establish Disease Mechanisms by Surveying GPCR Signaling by Masuho, Ikuo, Chavali, Sreenivas, Muntean, Brian S., Skamangas, Nickolas K., Simonyan, Kristina, Patil, Dipak N., Kramer, Grant M., Ozelius, Laurie, Babu, M. Madan, Martemyanov, Kirill A.

“…Despite the wealth of genetic information available, mechanisms underlying pathological effects of disease-associated mutations in components of G…”
Get full text

Mathematical modelling of swirling flow in hydraulic turbines for the full operating range by Susan-Resiga, R.F., Muntean, S., Avellan, F., Anton, I.

“…We introduce and validate a novel mathematical model for computing the radial profiles of both axial and circumferential velocity components, respectively, of…”
Get full text

Automated Live-Cell Imaging of Synapses in Rat and Human Neuronal Cultures by Green, Matthew V, Pengo, Thomas, Raybuck, Jonathan D, Naqvi, Tahmina, McMullan, Hannah M, Hawkinson, Jon E, Marron Fernandez de Velasco, Ezequiel, Muntean, Brian S, Martemyanov, Kirill A, Satterfield, Rachel, Young, Jr, Samuel M, Thayer, Stanley A

“…Synapse loss and dendritic damage correlate with cognitive decline in many neurodegenerative diseases, underlie neurodevelopmental disorders, and are…”
Get full text

Arrhythmogenic Hearts in PKD2 Mutant Mice Are Characterized by Cardiac Fibrosis, Systolic, and Diastolic Dysfunctions by Amirrad, Farideh, Pala, Rajasekharreddy, Shamloo, Kiumars, Muntean, Brian S, Nauli, Surya M

“…Autosomal dominant polycystic kidney disease (PKD) is a hereditary disorder affecting multiple organs, including the heart. PKD has been associated with many…”
Get full text

Dopaminergic signaling within the primary cilia in the renovascular system by Atkinson, Kimberly F, Kathem, Sarmed H, Jin, Xingjian, Muntean, Brian S, Abou-Alaiwi, Wissam A, Nauli, Andromeda M, Nauli, Surya M

“…Activation of dopamine receptor type-5 (DR5) has been known to reduce systemic blood pressure, most likely by increasing renal vasodilation and enhancing…”
Get full text

Roles of dopamine receptor on chemosensory and mechanosensory primary cilia in renal epithelial cells by Upadhyay, Viralkumar S, Muntean, Brian S, Kathem, Sarmed H, Hwang, Jangyoun J, Aboualaiwi, Wissam A, Nauli, Surya M

“…Dopamine plays a number of important physiological roles. However, activation of dopamine receptor type-5 (DR5) and its effect in renal epithelial cells have…”
Get full text

KCTD1 regulation of Adenylyl cyclase type 5 adjusts striatal cAMP signaling by Liao, Yini, Muntean, Brian S

“…Dopamine transfers information to striatal neurons, and disrupted neurotransmission leads to motor deficits observed in movement disorders. Striatal dopamine…”
Get full text

Numerical assessment of stress concentration in Francis runner blade — crown/band junctions by Predoiu, I–C, Marsavina, L., Muntean, S.

“…The paper presents the results of numerical investigation for stress distribution near runner blade-crown/band junctions. Starting with the geometrical…”
Get full text

Computation of stress distribution in a Francis turbine runner induced by fluid flow by Negru, R., Muntean, S., Marsavina, L., Susan-Resiga, R., Pasca, N.

“…► One-way coupled fluid–structure interaction. ► Pressure distribution computed on a Francis turbine runner blade. ► Stress distribution along junction between…”
Get full text

Identification of Novel Adenylyl Cyclase 5 (AC5) Signaling Networks in D1 and D2 Medium Spiny Neurons using Bimolecular Fluorescence Complementation Screening by Doyle, Trevor B., Muntean, Brian S., Ejendal, Karin F., Hayes, Michael P., Soto-Velasquez, Monica, Martemyanov, Kirill A., Dessauer, Carmen W., Hu, Chang-Deng, Watts, Val J.

“…Adenylyl cyclase type 5 (AC5), as the principal isoform expressed in striatal medium spiny neurons (MSNs), is essential for the integration of both stimulatory…”
Get full text

Dorsal Striatum Dynamically Incorporates Velocity Adjustments during Locomotion by Muntean, Brian S

Get full text

A Global Map of G Protein Signaling Regulation by RGS Proteins by Masuho, Ikuo, Balaji, Santhanam, Muntean, Brian S., Skamangas, Nickolas K., Chavali, Sreenivas, Tesmer, John J.G., Babu, M. Madan, Martemyanov, Kirill A.

“…The control over the extent and timing of G protein signaling is provided by the regulator of G protein signaling (RGS) proteins that deactivate G protein α…”
Get full text

Phase III Trial of Avelumab Maintenance After First-Line Induction Chemotherapy Versus Continuation of Chemotherapy in Patients With Gastric Cancers: Results From JAVELIN Gastric 100 by Moehler, Markus, Dvorkin, Mikhail, Boku, Narikazu, Özgüroğlu, Mustafa, Ryu, Min-Hee, Muntean, Alina S, Lonardi, Sara, Nechaeva, Marina, Bragagnoli, Arinilda C, Coşkun, Hasan S, Cubillo Gracian, Antonio, Takano, Toshimi, Wong, Rachel, Safran, Howard, Vaccaro, Gina M, Wainberg, Zev A, Silver, Matthew R, Xiong, Huiling, Hong, Janet, Taieb, Julien, Bang, Yung-Jue

“…The role of maintenance therapy for gastric (GC) or gastroesophageal junction cancer (GEJC) is unclear. We investigated avelumab (anti-programmed death…”
Get full text