Search Results - "Munro, Peter M."

Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups by Parfitt, David A., Lane, Amelia, Ramsden, Conor M., Carr, Amanda-Jayne F., Munro, Peter M., Jovanovic, Katarina, Schwarz, Nele, Kanuga, Naheed, Muthiah, Manickam N., Hull, Sarah, Gallo, Jean-Marc, da Cruz, Lyndon, Moore, Anthony T., Hardcastle, Alison J., Coffey, Peter J., Cheetham, Michael E.

“…Leber congenital amaurosis (LCA) is an inherited retinal dystrophy that causes childhood blindness. Photoreceptors are especially sensitive to an intronic…”
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Mutations in REEP6 Cause Autosomal-Recessive Retinitis Pigmentosa by Arno, Gavin, Agrawal, Smriti A., Eblimit, Aiden, Bellingham, James, Xu, Mingchu, Wang, Feng, Chakarova, Christina, Parfitt, David A., Lane, Amelia, Burgoyne, Thomas, Hull, Sarah, Carss, Keren J., Fiorentino, Alessia, Hayes, Matthew J., Munro, Peter M., Nicols, Ralph, Pontikos, Nikolas, Holder, Graham E., Black, Graeme, Hall, Georgina, Ingram, Stuart, Gillespie, Rachel, Manson, Forbes, Sergouniotis, Panagiotis, Inglehearn, Chris, Toomes, Carmel, Ali, Manir, McKibbin, Martin, Poulter, James, Khan, Kamron, Lord, Emma, Nemeth, Andrea, Downes, Susan, Yu, Jing, Lise, Stefano, Arno, Gavin, Fiorentino, Alessia, Ponitkos, Nikos, Plagnol, Vincent, Michaelides, Michel, Hardcastle, Alison J., Cheetham, Michael E., Webster, Andrew R., van Heyningen, Veronica, Asomugha, Chinwe, Raymond, F. Lucy, Moore, Anthony T., Plagnol, Vincent, Michaelides, Michel, Hardcastle, Alison J., Li, Yumei, Cukras, Catherine, Webster, Andrew R., Cheetham, Michael E., Chen, Rui

“…Retinitis pigmentosa (RP) is the most frequent form of inherited retinal dystrophy. RP is genetically heterogeneous and the genes identified to date encode…”
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Correction: The Tight Junction Associated Signalling Proteins ZO-1 and ZONAB Regulate Retinal Pigment Epithelium Homeostasis in Mice by Georgiadis, Anastasios, Tschernutter, Marion, Bainbridge, James W B, Balaggan, Kamaljit S, Mowat, Freya, West, Emma L, Munro, Peter M G, Thrasher, Adrian J, Matter, Karl, Balda, Maria S, Ali, Robin R

“…[This corrects the article DOI: 10.1371/journal.pone.0015730.]…”
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Regulation of cell protrusions by small GTPases during fusion of the neural folds by Rolo, Ana, Savery, Dawn, Escuin, Sarah, de Castro, Sandra C, Armer, Hannah E J, Munro, Peter M G, Molè, Matteo A, Greene, Nicholas D E, Copp, Andrew J

“…Epithelial fusion is a crucial process in embryonic development, and its failure underlies several clinically important birth defects. For example, failure of…”
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The Drusenlike Phenotype in Aging Ccl2-Knockout Mice Is Caused by an Accelerated Accumulation of Swollen Autofluorescent Subretinal Macrophages by Luhmann, Ulrich F. O, Robbie, Scott, Munro, Peter M. G, Barker, Susie E, Duran, Yanai, Luong, Vy, Fitzke, Frederick W, Bainbridge, James W. B, Ali, Robin R, MacLaren, Robert E

“…Drusen, which are defined clinically as yellowish white spots in the outer retina, are cardinal features of age-related macular degeneration (AMD)…”
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Characterization of the Limbal Epithelial Stem Cell Niche: Novel Imaging Techniques Permit In Vivo Observation and Targeted Biopsy of Limbal Epithelial Stem Cells by Shortt, Alex J., Secker, Genevieve A., Munro, Peter M., Khaw, Peng T., Tuft, Stephen J., Daniels, Julie T.

“…It is anticipated that stem cell (SC) therapy will enable the regeneration of diseased tissues and organs. Understanding SC niches is an essential step toward…”
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The tight junction associated signalling proteins ZO-1 and ZONAB regulate retinal pigment epithelium homeostasis in mice by Georgiadis, Anastasios, Tschernutter, Marion, Bainbridge, James W B, Balaggan, Kamaljit S, Mowat, Freya, West, Emma L, Munro, Peter M G, Thrasher, Adrian J, Matter, Karl, Balda, Maria S, Ali, Robin R

“…Cell-cell adhesion regulates the development and function of epithelia by providing mechanical support and by guiding cell proliferation and differentiation…”
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Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration by Athanasiou, Dimitra, Aguila, Monica, Opefi, Chikwado A, South, Kieron, Bellingham, James, Bevilacqua, Dalila, Munro, Peter M, Kanuga, Naheed, Mackenzie, Francesca E, Dubis, Adam M, Georgiadis, Anastasios, Graca, Anna B, Pearson, Rachael A, Ali, Robin R, Sakami, Sanae, Palczewski, Krzysztof, Sherman, Michael Y, Reeves, Philip J, Cheetham, Michael E

“…Protein misfolding caused by inherited mutations leads to loss of protein function and potentially toxic 'gain of function', such as the dominant P23H…”
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Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation by Zihni, Ceniz, Munro, Peter M G, Elbediwy, Ahmed, Keep, Nicholas H, Terry, Stephen J, Harris, John, Balda, Maria S, Matter, Karl

“…Epithelial cells develop morphologically characteristic apical domains that are bordered by tight junctions, the apical-lateral border. Cdc42 and its effector…”
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The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation by Saliba, Richard S, Munro, Peter M G, Luthert, Philip J, Cheetham, Michael E

“…Mutations in the photopigment rhodopsin are the major cause of autosomal dominant retinitis pigmentosa. The majority of mutations in rhodopsin lead to…”
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Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling by Luhmann, Ulrich F O, Lange, Clemens A, Robbie, Scott, Munro, Peter M G, Cowing, Jill A, Armer, Hannah E J, Luong, Vy, Carvalho, Livia S, MacLaren, Robert E, Fitzke, Frederick W, Bainbridge, James W B, Ali, Robin R

“…Microglia and macrophages are recruited to sites of retinal degeneration where local cytokines and chemokines determine protective or neurotoxic microglia…”
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Autologous Transplantation of the Retinal Pigment Epithelium and Choroid in the Treatment of Neovascular Age-Related Macular Degeneration by MacLaren, Robert E., DPhil, FRCOphth, Uppal, Gurmit S., MRCOphth, Balaggan, Kamaljit S., MRCOphth, Tufail, Adnan, MD, FRCOphth, Munro, Peter M.G., PhD, Milliken, Andrew B., FCOptom, Ali, Robin R., PhD, Rubin, Gary S., PhD, Aylward, G. William, MD, FRCOphth, da Cruz, Lyndon, PhD, FRCOphth

“…Purpose To assess excision of choroidal new vessels (CNV) combined with autologous transplantation of the equatorial retinal pigment epithelium (RPE) as a…”
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Real-Time In Vivo Imaging of Retinal Cell Apoptosis after Laser Exposure by Schmitz-Valckenberg, Steffen, Guo, Li, Maass, Annelie, Cheung, William, Vugler, Anthony, Moss, Stephen E, Munro, Peter M. G, Fitzke, Frederick W, Cordeiro, M. Francesca

“…To investigate whether the detection of apoptosing retinal cells (DARC) could detect cells undergoing apoptosis in a laser model of retinal damage. Laser…”
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Mutations in TOPORS Cause Autosomal Dominant Retinitis Pigmentosa with Perivascular Retinal Pigment Epithelium Atrophy by Chakarova, Christina F., Papaioannou, Myrto G., Khanna, Hemant, Lopez, Irma, Waseem, Naushin, Shah, Amna, Theis, Torsten, Friedman, James, Maubaret, Cecilia, Bujakowska, Kinga, Veraitch, Brotati, El-Aziz, Mai M. Abd, Prescott, De Quincy, Parapuram, Sunil K., Bickmore, Wendy A., Munro, Peter M.G., Gal, Andreas, Hamel, Christian P., Marigo, Valeria, Ponting, Chris P., Wissinger, Bernd, Zrenner, Eberhart, Matter, Karl, Swaroop, Anand, Koenekoop, Robert K., Bhattacharya, Shomi S.

“…We report mutations in the gene for topoisomerase I–binding RS protein ( TOPORS) in patients with autosomal dominant retinitis pigmentosa (adRP) linked to…”
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Basement membrane changes in capillaries of the ageing human retina by Powner, Michael B, Scott, Andrew, Zhu, Meidong, Munro, Peter M G, Foss, Alexander J E, Hageman, Gregory S, Gillies, Mark C, Fruttiger, Marcus

“…The ultrastructural appearance of retinal capillaries can yield important information about disease mechanisms, but is not well characterised in human post…”
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Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy by Ali, Robin R, Sarra, Gian-Marco, Stephens, Clare, Alwis, Mahesh de, Bainbridge, James W.B, Munro, Peter M, Fauser, Sascha, Reichel, Martin B, Kinnon, Christine, Hunt, David M, Bhattacharya, Shomi S, Thrasher, Adrian J

“…The gene Prph2 encodes a photoreceptor-specific membrane glycoprotein, peripherin-2 (also known as peripherin/rds), which is inserted into the rims of…”
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WASp‐dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts by Malinova, Dessislava, Fritzsche, Marco, Nowosad, Carla R., Armer, Hannah, Munro, Peter M. G., Blundell, Michael P., Charras, Guillaume, Tolar, Pavel, Bouma, Gerben, Thrasher, Adrian J.

“…Novel DC podosomes surround the central MHCII cluster to stabilize the IS; a driver role for the DC actin cytoskeleton. The immunological synapse is a highly…”
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REEP6 deficiency leads to retinal degeneration through disruption of ER homeostasis and protein trafficking by Agrawal, Smriti A, Burgoyne, Thomas, Eblimit, Aiden, Bellingham, James, Parfitt, David A, Lane, Amelia, Nichols, Ralph, Asomugha, Chinwe, Hayes, Matthew J, Munro, Peter M, Xu, Mingchu, Wang, Keqing, Futter, Clare E, Li, Yumei, Chen, Rui, Cheetham, Michael E

“…Retinitis pigmentosa (RP) is the most common form of inherited retinal dystrophy. We recently identified mutations in REEP6, which encodes the receptor…”
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Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates by Phillips, Helen M, Dollfus, Hélène, Leroux, Michel R, Chapple, J Paul, Jagger, Daniel J, Ross, Alison J, Katsanis, Nicholas, Forge, Andrew, Hill, Josephine, Kemp, David T, Eliot, Marie-Madeleine, Lupski, James R, Leitch, Carmen C, Murdoch, Jennifer N, Beales, Philip L, Fisher, Shannon, Tan, Perciliz L, Henderson, Deborah J, Tada, Masazumi, Eichers, Erica R, May-Simera, Helen, Munro, Peter M, Copp, Andrew J, Kai, Masatake

“…The evolutionarily conserved planar cell polarity (PCP) pathway (or noncanonical Wnt pathway) drives several important cellular processes, including epithelial…”
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Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration by Luhmann, Ulrich F.O., Carvalho, Livia S., Robbie, Scott J., Cowing, Jill A., Duran, Yanai, Munro, Peter M.G., Bainbridge, James W.B., Ali, Robin R.

“…Monocytes, macrophages, dendritic cells and microglia play critical roles in the local immune response to acute and chronic tissue injury and have been…”
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