Search Results - "Munoz, Ruben M."

Blocking Nerve Growth Factor Signaling Reduces the Neural Invasion Potential of Pancreatic Cancer Cells by Bapat, Aditi A, Munoz, Ruben M, Von Hoff, Daniel D, Han, Haiyong

“…Perineural invasion (PNI) is thought to be one of the factors responsible for the high rate of tumor recurrence after surgery and the pain generation…”
Get full text

Down-regulation of Yes Associated Protein 1 expression reduces cell proliferation and clonogenicity of pancreatic cancer cells by Diep, Caroline H, Zucker, Kelly M, Hostetter, Galen, Watanabe, Aprill, Hu, Chengcheng, Munoz, Ruben M, Von Hoff, Daniel D, Han, Haiyong

“…The Hippo pathway regulates organ size by inhibiting cell proliferation and promoting cell apoptosis upon its activation. The Yes Associated Protein 1 (YAP1)…”
Get full text

Identification of a novel inhibitor of urokinase-type plasminogen activator by Zhu, Ming, Gokhale, Vijay M, Szabo, Lajos, Munoz, Ruben M, Baek, Hyounggee, Bashyam, Sridevi, Hurley, Laurence H, Von Hoff, Daniel D, Han, Haiyong

“…Urokinase-type plasminogen activator (uPA), a highly restricted serine protease, plays an important role in the regulation of diverse physiologic and…”
Get full text

An Exosome-based Transcriptomic Signature for Noninvasive, Early Detection of Patients With Pancreatic Ductal Adenocarcinoma: A Multicenter Cohort Study by Nakamura, Kota, Zhu, Zhongxu, Roy, Souvick, Jun, Eunsung, Han, Haiyong, Munoz, Ruben M., Nishiwada, Satoshi, Sharma, Geeta, Cridebring, Derek, Zenhausern, Frederic, Kim, Seungchan, Roe, Denise J., Darabi, Sourat, Han, In-Woong, Evans, Douglas B., Yamada, Suguru, Demeure, Michael J., Becerra, Carlos, Celinski, Scott A., Borazanci, Erkut, Tsai, Susan, Kodera, Yasuhiro, Park, Joon Oh, Bolton, John S., Wang, Xin, Kim, Song Cheol, Von Hoff, Daniel, Goel, Ajay

“…Pancreatic ductal adenocarcinoma (PDAC) incidence is rising worldwide, and most patients present with an unresectable disease at initial diagnosis. Measurement…”
Get full text

Comparing Aurora A and Aurora B as molecular targets for growth inhibition of pancreatic cancer cells by Warner, Steven L, Munoz, Ruben M, Stafford, Phillip, Koller, Erich, Hurley, Laurence H, Von Hoff, Daniel D, Han, Haiyong

“…To address the increased need to understand the similarities and differences in targeting Aurora A or Aurora B for the treatment of cancer, we systematically…”
Get full text

Synergistic Effect between Erlotinib and MEK Inhibitors in KRAS Wild-Type Human Pancreatic Cancer Cells by DIEP, Caroline H, MUNOZ, Ruben M, CHOUDHARY, Ashish, VON HOFF, Daniel D, HAIYONG HAN

“…The combination of erlotinib and gemcitabine has shown a small but statistically significant survival advantage when compared with gemcitabine alone in…”
Get full text

A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer by Antal, Corina E., Oh, Tae Gyu, Aigner, Stefan, Luo, En-Ching, Yee, Brian A., Campos, Tania, Tiriac, Hervé, Rothamel, Katherine L., Cheng, Zhang, Jiao, Henry, Wang, Allen, Hah, Nasun, Lenkiewicz, Elizabeth, Lumibao, Jan C., Truitt, Morgan L., Estepa, Gabriela, Banayo, Ester, Bashi, Senada, Esparza, Edgar, Munoz, Ruben M., Diedrich, Jolene K., Sodir, Nicole M., Mueller, Jasmine R., Fraser, Cory R., Borazanci, Erkut, Propper, David, Von Hoff, Daniel D., Liddle, Christopher, Yu, Ruth T., Atkins, Annette R., Han, Haiyong, Lowy, Andrew M., Barrett, Michael T., Engle, Dannielle D., Evan, Gerard I., Yeo, Gene W., Downes, Michael, Evans, Ronald M.

“…Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy in need of new therapeutic options. Using unbiased analyses of super-enhancers (SEs) as…”
Get full text

Kinome-wide siRNA screening identifies molecular targets mediating the sensitivity of pancreatic cancer cells to Aurora kinase inhibitors by Xie, Lifang, Kassner, Michelle, Munoz, Ruben M., Que, Qiang Q., Kiefer, Jeff, Zhao, Yu, Mousses, Spyro, Yin, Hongwei H., Von Hoff, Daniel D., Han, Haiyong

“…PDGFR inhibitors (e.g. imatinib) sensitize pancreatic cancer cells to the treatment of Aurora kinase inhibitors (e.g. PHA-739358). Aurora kinases are a family…”
Get full text

Isolation and characterization of muscle fatigue substance with anti-tumor activities by Munoz, Ruben M, Han, Haiyong, Tegeler, Tony, Petritis, Konstantinos, Von Hoff, Daniel D, Hoffman, Stanley A

“…Research during the 1950's indicated that exercise played a role in the reduction of tumor growth. In the 1960's our studies confirmed that tumor-bearing rats,…”
Get full text

Pdx-1-driven overexpression of aurora a kinase induces mild ductal dysplasia of pancreatic ducts near islets in transgenic mice by Warner, Steven L, Muñoz, Ruben M, Bearss, David J, Grippo, Paul, Han, Haiyong, Von Hoff, Daniel D

“…To further explore the oncogenic activity of Aurora A kinase while attempting to develop a useful mouse model for pancreatic cancer, Aurora A kinase was…”
Get full text

Transcriptional activation of the human epidermal growth factor receptor promoter by human p53 by Ludes-Meyers, J H, Subler, M A, Shivakumar, C V, Munoz, R M, Jiang, P, Bigger, J E, Brown, D R, Deb, S P, Deb, S

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

p53-independent response to cisplatin and oxaliplatin in MMTV-ras mouse salivary tumors by Petit, Thierry, Bearss, David J, Troyer, Dean A, Munoz, Ruben M, Windle, Jolene J

“…A transgenic mouse tumor model was used to investigate the role of p53 in tumor response to two different platinum-based chemotherapeutic agents: (a) cisplatin…”
Get full text

The mitotic serine threonine kinase, Aurora-2, is a potential target for drug development in human pancreatic cancer by Rojanala, Sangeeta, Han, Haiyong, Muñoz, Rubén M, Browne, Walden, Nagle, Raymond, Von Hoff, Daniel D, Bearss, David J

“…Aurora-2 is a serine threonine kinase that associates with the centrosome. Overexpression or ectopic expression of Aurora-2 appears to alter centrosome number…”
Get full text

Changes in prostate-specific antigen (PSA) level correlate with growth inhibition of prostate cancer cells treated in vitro with a novel anticancer drug, irofulven by WOYNAROWSKA, Barbara A, HIGDON, Arlene L, MUNOZ, Ruben M, BUSHONG, Perry, WATERS, Stephen J

“…Irofulven (hydroxymethylacylfulvene, HMAF, MGI 114) is a novel agent with alkylating activity and a potent inducer of apoptosis. It is currently undergoing…”
Get full text

Abstract 3389: An exosomal miRNA-based liquid biopsy signature for the noninvasive early detection of pancreatic ductal adenocarcinoma by Nakamura, Kota, Roy, Souvick, Zhu, Zhongxu, Jun, Eunsung, Han, Haiyong, Munoz, Ruben M., Nishiwada, Satoshi, Sharma, Geeta, Cridebring, Derek, Zenhausern, Frederic, Kim, Seungchan, Roe, Denise, Darabi, Sourat, Han, In Woong, Evans, Douglas, Yamada, Suguru, Demure, Michael, Celinski, Scott A., Borazanci, Erkut, Tsai, Susan, Bolton, John, Kodera, Yasuhiro, Park, Joon Oh, Kim, Song Cheol, Wang, Xin, Von Hoff, Daniel, Goel, Ajay

“…Background: Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second leading cause of cancer-related deaths in the United States by 2030. Most…”
Get full text

Abstract B213: Isolation of muscle fatigue substance(s) with antitumor activities by Munoz, Ruben M., Han, Haiyong, Von Hoff, Daniel D., Hoffman, Stanley

“…It has been scientifically established that regular physical exercise can reduce cancer risk by as much as 40% (Newton et al. 2008 Curr Treat. Options Oncol…”
Get full text

Abstract B152: Modulating the activity of nerve growth factor (NGF) and its receptors tropomyosin-related kinase A (TRKA) and p75 neurotrophin receptor (p75NTR) in perineural invasion (PNI) in pancreatic cancer by Bapat, Aditi A., Munoz, Ruben M., Maredia, Saaiqa, Von Hoff, Daniel D., Han, Haiyong

“…Pancreatic cancer is the fourth leading cause of cancer-related death in the US with a 5-year survival rate of less than 5%. Even after surgery and…”
Get full text

Synergistic effect between erlotinib and MEK inhibitors in KRAS wildtype human pancreatic cancer cells by Diep, Caroline H., Munoz, Ruben M., Choudhary, Ashish, Von Hoff, Daniel D., Han, Haiyong

Get full text

The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo by Grand, Cory L, Han, Haiyong, Muñoz, Rubén M, Weitman, Steve, Von Hoff, Daniel D, Hurley, Laurence H, Bearss, David J

“…Cationic porphyrins are being studied as possible anticancer agents because of their ability to bind to and stabilize DNA guanine quadruplexes…”
Get full text

p53-independent Response to Cisplatin and Oxaliplatin in MMTV-ras Mouse Salivary Tumors1 by Thierry Petit, David J. Bearss, Dean A. Troyer, Ruben M. Munoz, Jolene J. Windle

“…A transgenic mouse tumor model was used to investigate the role of p53 in tumor response to two different platinum-based chemotherapeutic agents: ( a )…”
Get full text