Search Results - "Munoz, Carlos J."

Apohemoglobin-haptoglobin complex alleviates iron toxicity in mice with β-thalassemia via scavenging of cell-free hemoglobin and heme by Munoz, Carlos J., Pires, Ivan S., Jani, Vinay, Gopal, Srila, Palmer, Andre F., Cabrales, Pedro

“…β-thalassemia is a genetic hemoglobin (Hb) disorder that affects millions of people world-wide. It is characterized by ineffective erythropoiesis and anemia…”
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Toxic side-effects of diaspirin cross-linked human hemoglobin are attenuated by the apohemoglobin-haptoglobin complex by Munoz, Carlos J., Lucas, Daniela, Martinez, Jacinda, Ricario, Mia, O'Boyle, Quintin T., Pires, Ivan S., Palmer, Andre F., Cabrales, Pedro

“…Alpha-alpha diaspirin-crosslinked human hemoglobin (DCLHb or ααHb) was a promising early generation red blood cell (RBC) substitute. The DCLHb was developed…”
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Safety profile of high molecular weight polymerized hemoglobins by Muller, Cynthia R., Williams, Alexander T., Munoz, Carlos J., Eaker, Allyn M., Breton, Amanda N., Palmer, Andre F., Cabrales, Pedro

“…Background Hemoglobin (Hb)‐based oxygen (O2) carriers (HBOCs) are being developed as alternatives to red blood cells and blood when these products are…”
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Acknowledging uncertainty in evolutionary reconstructions of ecological niches by Owens, Hannah L., Ribeiro, Vivian, Saupe, Erin E., Cobos, Marlon E., Hosner, Peter A., Cooper, Jacob C., Samy, Abdallah M., Barve, Vijay, Barve, Narayani, Muñoz‐R., Carlos J., Peterson, A. Townsend

“…Reconstructing ecological niche evolution can provide insight into the biogeography and diversification of evolving lineages. However, comparative phylogenetic…”
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Robotic surgery and anesthesia for pediatric urologic procedures by Muñoz, Carlos J, Nguyen, Hiep T, Houck, Constance S

“…Minimally invasive approaches to pediatric surgery have become increasingly popular over the last 15 years. With the advent of robotically controlled…”
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Application of negative tissue interstitial pressure improves functional capillary density after hemorrhagic shock in the absence of volume resuscitation by Jani, Vinay P., Jani, Vivek P., Munoz, Carlos J., Govender, Krianthan, Williams, Alexander T., Cabrales, Pedro

“…Microvascular fluid exchange is primarily dependent on Starling forces and both the active and passive myogenic response of arterioles and post‐capillary…”
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Apohemoglobin‐haptoglobin (Apohb‐Hp) Complex as a Vasculo‐protective Agent in Hypoxia Induced Vaso‐occlusion in Sickle Cell Disease by Munoz, Carlos J., Gopal, Srila, Cabrales, Pedro

“…Sickle Cell Disease is associated with episodes of vaso‐occlusive crises (VOCs) caused by hemoglobin S (HbS) polymerization and resultant microvascular…”
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A Review on Microvascular Hemodynamics: The Control of Blood Flow Distribution and Tissue Oxygenation by Munoz, Carlos J, Lucas, Alfredo, Williams, Alexander T, Cabrales, Pedro

“…The microcirculation is a complex network of vessels ranging from as large as 100 μm to as small as 5 μm. This complex network is responsible for the…”
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Coadministration of PEGylated apohemoglobin and haptoglobin can limit vascular dysfunction in the microcirculation and prevent acute inflammation by Munoz, Carlos J, Lucas, Daniela, Muller, Cynthia R, Martinez, Jacinda, O'Boyle, Quintin, Pires, Ivan S, Palmer, Andre F, Cabrales, Pedro

“…Unfortunately, during pathological conditions resulting in chronic hemolysis cell-free hemoglobin (Hb) is released into the circulation that releases free…”
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Negative pressure increases microvascular perfusion during severe hemorrhagic shock by Govender, Krianthan, Munoz, Carlos J., Williams, Alexander T., Cabrales, Pedro

“…Hemorrhagic shock (HS) is a severe life-threatening condition characterized by loss of blood volume and a lack of oxygen (O2) delivery to tissues. The…”
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An Overview of the Regional Experiments for Land-atmosphere Exchanges 2012 (REFLEX 2012) Campaign by Timmermans, Wim J., van der Tol, Christiaan, Timmermans, Joris, Ucer, Murat, Chen, Xuelong, Alonso, Luis, Moreno, Jose, Carrara, Arnaud, Lopez, Ramon, de la Cruz Tercero, Fernando, Corcoles, Horacio L., de Miguel, Eduardo, Sanchez, Jose A. G., Pérez, Irene, Franch, Belen, Munoz, Juan-Carlos J., Skokovic, Drazen, Sobrino, Jose, Soria, Guillem, MacArthur, Alasdair, Vescovo, Loris, Reusen, Ils, Andreu, Ana, Burkart, Andreas, Cilia, Chiara, Contreras, Sergio, Corbari, Chiara, Calleja, Javier F., Guzinski, Radoslaw, Hellmann, Christine, Herrmann, Ittai, Kerr, Gregoire, Lazar, Adina-Laura, Leutner, Benjamin, Mendiguren, Gorka, Nasilowska, Sylwia, Nieto, Hector, Pachego-Labrador, Javier, Pulanekar, Survana, Raj, Rahul, Schikling, Anke, Siegmann, Bastian, von Bueren, Stefanie, Su, Zhongbo (Bob)

“…The REFLEX 2012 campaign was initiated as part of a training course on the organization of an airborne campaign to support advancement of the understanding of…”
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Airway Impedance: A Novel Diagnostic Tool to Predict Extraesophageal Airway Inflammation by Rosen, Rachel, Rahbar, Reza, Watters, Karen, Hseu, Anne, Munoz, Carlos J., Ferrari, Lynne, Holzman, Robert, Mohammad, Shoaib, Cohen, Alexandra, Du, Maritha, Akkara, Anna, Catacora, Andrea, Simoneau, Tregony, Connearney, Sarah, Mitchell, Paul, Nurko, Samuel

“…To validate a novel biomarker, airway impedance for extraesophageal disease. We prospectively recruited patients with respiratory symptoms undergoing combined…”
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Implications of microvascular dysfunction and nitric oxide mediated inflammation in severe COVID-19 infection by Jani, Vinay P., Munoz, Carlos J., Govender, Krianthan, Williams, Alexander T., Cabrales, Pedro

“…Infection with COVID-19 has resulted in over 276,000 deaths in the United States and over 1.5 million deaths globally, with upwards of 15% of patients…”
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Attenuating ischemia-reperfusion injury with polymerized albumin by Belcher, Donald A, Williams, Alexander T, Munoz, Carlos J, Muller, Cynthia R, Walser, Cynthia, Palmer, Andre F, Cabrales, Pedro

“…Ischemia-reperfusion injury increased vascular permeability, resulting in fluid extravasation from the intravascular compartment into the tissue space. Fluid…”
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Apohemoglobin-haptoglobin complex attenuates the pathobiology of circulating acellular hemoglobin and heme by Munoz, Carlos J, Pires, Ivan S, Baek, Jin Hyen, Buehler, Paul W, Palmer, Andre F, Cabrales, Pedro

“…Haptoglobin (Hp) is the plasma protein that binds and clears cell-free hemoglobin (Hb), whereas apohemoglobin (apoHb, i.e., Hb devoid of heme) can bind heme…”
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Purification and analysis of a protein cocktail capable of scavenging cell‐free hemoglobin, heme, and iron by Pires, Ivan S., Govender, Krianthan, Munoz, Carlos J., Williams, Alexander T., O'Boyle, Quintin T., Savla, Chintan, Cabrales, Pedro, Palmer, Andre F.

“…Background Hemolysis releases toxic cell‐free hemoglobin (Hb), heme, and iron, which overwhelm their natural scavenging mechanisms during acute or chronic…”
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Degree of PEGylatation of Lumbricus terrestris Hemoglobin Improves Microcirculatory Blood Flow but Increases the Rate of Auto-Oxidation by Munoz, Carlos J., Lucas, Daniela, Muller, Cynthia R., Breton, Amanda, Jani, Vinay, Savla, Chintan, Palmer, Andre F., Cabrales, Pedro

“…Introduction: The demand for red blood cells (RBCs) is on the rise due to the increasing diagnosis of chronic diseases such as sickle cell anemia, malaria, and…”
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Focal drug-resistant temporal lobe epilepsy associated with an ipsilateral anterior choroidal artery aneurysm: illustrative case by Phillips, H Westley, Rangwala, Shivani D, Papadakis, Joanna, Segar, David J, Tsuboyama, Melissa, Pinto, Anna L R, Harmon, Joseph P, Soriano, Sulpicio G, Munoz, Carlos J, Madsen, Joseph R, See, Alfred P, Stone, Scellig S

“…The occurrence of both an intracranial aneurysm and epilepsy, especially drug-resistant epilepsy (DRE), is rare. Although the overall incidence of aneurysms…”
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Enhanced Photodynamic Therapy Using the Apohemoglobin-Haptoglobin Complex as a Carrier of Aluminum Phthalocyanine by Pires, Ivan S, O’Boyle, Quintin T, Munoz, Carlos J, Savla, Chintan, Cabrales, Pedro, Palmer, Andre F

“…Photodynamic therapy (PDT) has been shown to effectively treat cancer by producing cytotoxic reactive oxygen species via excitation of photosensitizer (PS)…”
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Anesthesia for Posterior Tracheopexy in Pediatric Patients by Muñoz, Carlos J, Kuo, Frederick H, Hernández, Michael R, Alrayashi, Walid, Sullivan, Cornelius A, Wang, Jue T, Jennings, Russell W

“…Tracheobronchomalacia refers to an abnormally excessive collapse of the trachea and/or bronchi during exhalation. In the pediatric population,…”
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