Search Results - "Munne, Pauliina M"

Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer by Lee, Joyce V., Housley, Filomena, Yau, Christina, Nakagawa, Rachel, Winkler, Juliane, Anttila, Johanna M., Munne, Pauliina M., Savelius, Mariel, Houlahan, Kathleen E., Van de Mark, Daniel, Hemmati, Golzar, Hernandez, Grace A., Zhang, Yibing, Samson, Susan, Baas, Carole, Kok, Marleen, Esserman, Laura J., van ‘t Veer, Laura J., Rugo, Hope S., Curtis, Christina, Klefström, Juha, Matloubian, Mehrdad, Goga, Andrei

“…Few patients with triple negative breast cancer (TNBC) benefit from immune checkpoint inhibitors with complete and durable remissions being quite rare…”
Get full text

Author Correction: Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer by Lee, Joyce V., Housley, Filomena, Yau, Christina, Nakagawa, Rachel, Winkler, Juliane, Anttila, Johanna M., Munne, Pauliina M., Savelius, Mariel, Houlahan, Kathleen E., Van de Mark, Daniel, Hemmati, Golzar, Hernandez, Grace A., Zhang, Yibing, Samson, Susan, Baas, Carole, Kok, Marleen, Esserman, Laura J., van ‘t Veer, Laura J., Rugo, Hope S., Curtis, Christina, Klefström, Juha, Matloubian, Mehrdad, Goga, Andrei

Get full text

Tinkering with the inductive mesenchyme: Sostdc1 uncovers the role of dental mesenchyme in limiting tooth induction by Munne, Pauliina M, Tummers, Mark, Järvinen, Elina, Thesleff, Irma, Jernvall, Jukka

“…Like epithelial organs in general, tooth development involves inductive crosstalk between the epithelium and the mesenchyme. Classically, the inductive…”
Get full text

Sortilin‐related receptor is a druggable therapeutic target in breast cancer by Al‐Akhrass, Hussein, Pietilä, Mika, Lilja, Johanna, Vesilahti, Ella‐Maria, Anttila, Johanna M., Haikala, Heidi M., Munne, Pauliina M., Klefström, Juha, Peuhu, Emilia, Ivaska, Johanna

“…In breast cancer, the currently approved anti‐receptor tyrosine‐protein kinase erbB‐2 (HER2) therapies do not fully meet the expected clinical goals due to…”
Get full text

Respiratory complex I regulates dendritic cell maturation in explant model of human tumor immune microenvironment by Turpin, Rita, Liu, Ruixian, Munne, Pauliina M, Peura, Aino, Rannikko, Jenna H, Philips, Gino, Boeckx, Bram, Salmelin, Natasha, Hurskainen, Elina, Suleymanova, Ilida, Aung, July, Vuorinen, Elisa M, Lehtinen, Laura, Mutka, Minna, Kovanen, Panu E, Niinikoski, Laura, Meretoja, Tuomo J, Mattson, Johanna, Mustjoki, Satu, Saavalainen, Päivi, Goga, Andrei, Lambrechts, Diether, Pouwels, Jeroen, Hollmén, Maija, Klefström, Juha

“…BackgroundCombining cytotoxic chemotherapy or novel anticancer drugs with T-cell modulators holds great promise in treating advanced cancers. However, the…”
Get full text

Splitting placodes: effects of bone morphogenetic protein and Activin on the patterning and identity of mouse incisors by Munne, Pauliina M, Felszeghy, Szabolcs, Jussila, Maria, Suomalainen, Marika, Thesleff, Irma, Jernvall, Jukka

“…The single large rodent incisor in each jaw quadrant is evolutionarily derived from a mammalian ancestor with many small incisors. The embryonic placode giving…”
Get full text

Fibrin Stiffness Regulates Phenotypic Plasticity of Metastatic Breast Cancer Cells by Heilala, Maria, Lehtonen, Arttu, Arasalo, Ossi, Peura, Aino, Pokki, Juho, Ikkala, Olli, Nonappa, Klefström, Juha, Munne, Pauliina M.

“…The extracellular matrix (ECM)‐regulated phenotypic plasticity is crucial for metastatic progression of triple negative breast cancer (TNBC). While ECM…”
Get full text

Fibrin Stiffness Regulates Phenotypic Plasticity of Metastatic Breast Cancer Cells (Adv. Healthcare Mater. 31/2023) by Heilala, Maria, Lehtonen, Arttu, Arasalo, Ossi, Peura, Aino, Pokki, Juho, Ikkala, Olli, Nonappa, Klefström, Juha, Munne, Pauliina M.

“…Fibrin Hydrogels Inspired by the connection between fibrin and metastasis, article 2301137 by Nonappa, Pauliina M. Munne, and co‐workers describes the use of…”
Get full text

Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer by Munne, Pauliina M., Martikainen, Lahja, Räty, Iiris, Bertula, Kia, Nonappa, Ruuska, Janika, Ala-Hongisto, Hanna, Peura, Aino, Hollmann, Babette, Euro, Lilya, Yavuz, Kerim, Patrikainen, Linda, Salmela, Maria, Pokki, Juho, Kivento, Mikko, Väänänen, Juho, Suomi, Tomi, Nevalaita, Liina, Mutka, Minna, Kovanen, Panu, Leidenius, Marjut, Meretoja, Tuomo, Hukkinen, Katja, Monni, Outi, Pouwels, Jeroen, Sahu, Biswajyoti, Mattson, Johanna, Joensuu, Heikki, Heikkilä, Päivi, Elo, Laura L., Metcalfe, Ciara, Junttila, Melissa R., Ikkala, Olli, Klefström, Juha

“…Breast cancer is now globally the most frequent cancer and leading cause of women’s death. Two thirds of breast cancers express the luminal estrogen…”
Get full text

TP53 supports basal-like differentiation of mammary epithelial cells by preventing translocation of deltaNp63 into nucleoli by Munne, Pauliina M., Gu, Yuexi, Tumiati, Manuela, Gao, Ping, Koopal, Sonja, Uusivirta, Sanna, Sawicki, Janet, Wei, Gong-Hong, Kuznetsov, Sergey G.

“…Multiple observations suggest a cell type-specific role for TP53 in mammary epithelia. We developed an in vitro assay, in which primary mouse mammary…”
Get full text

Analysis of tissue interactions in ectodermal organ culture by Munne, Pauliina M, Närhi, Katja, Michon, Frederic

“…The morphogenesis of ectodermal organs is regulated by epithelial mesenchymal interactions mediated by conserved signaling molecules. Analyzing the roles of…”
Get more information

Abstract B036: Micromechanical regulation of tumor immune microenvironment by Peura, Aino, Turpin, Rita, Salmela, Maria, Liu, Ruixian, Mikkonen, Piia, Klefström, Juha, Munne, Pauliina M

“…Abstract Although the prognosis of primary breast cancer (BC) is considerably good, the prognosis of therapy-resistant, metastatic BC remains rather poor, thus…”
Get full text

Abstract 2966: Novel ex vivo model for ERα positive breast cancer by Munne, Pauliina M., Martikainen, Lahja, Räty, Iiris, Bertula, Kia, Nonappa, Nonappa, Peura, Aino, Mutka, Minna, Leidenius, Marjut, Meretoja, Tuomo, Kovanen, Panu, Mattson, Johanna, Heikkila, Paivi, Joensuu, Heikki, Ikkala, Olli, Klefstrom, Juha T.

“…Abstract Three-dimensional ex vivo cultures from patient-derived tumor tissue offer new opportunities for drug development and personalized treatment of…”
Get full text

Abstract A027: Targeting MYC-induced reprogramming of mitochondrial metabolism in breast cancer by Anttila, Johanna M., Savelius, Mariel, Nicorici, Daniel, Awadhpersad, Ryan, Munne, Pauliina M., Id, Linda, Tervonen, Topi A., Jackson, Christopher, Nieminen, Anni I., Klefström, Juha

“…Abstract Oncogenic MYC is frequently overexpressed in breast cancer, and its overexpression is associated with aggressiveness and unfavorable prognosis of…”
Get full text