Search Results - "Munkarah, Adnan R"

Metformin limits the adipocyte tumor-promoting effect on ovarian cancer by Tebbe, Calvin, Chhina, Jasdeep, Dar, Sajad A, Sarigiannis, Kalli, Giri, Shailendra, Munkarah, Adnan R, Rattan, Ramandeep

“…Omental adipocytes promote ovarian cancer by secretion of adipokines, cytokines and growth factors, and acting as fuel depots. We investigated if metformin…”
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The influence of comorbid conditions on racial disparities in endometrial cancer survival by Ruterbusch, Julie J., MPH, Ali-Fehmi, Rouba, MD, Olson, Sara H., PhD, Sealy-Jefferson, Shawnita, PhD, Rybicki, Benjamin A., PhD, Hensley-Alford, Sharon, PhD, Elshaikh, Mohamed A., MD, Gaba, Arthur R., MD, Schultz, Daniel, MD, Munkarah, Adnan R., MD, Cote, Michele L., PhD

“…Objective There are known disparities in endometrial cancer survival with black women who experience a greater risk of death compared with white women. The…”
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Phase III Trial of Doxorubicin Plus Cisplatin With or Without Paclitaxel Plus Filgrastim in Advanced Endometrial Carcinoma: A Gynecologic Oncology Group Study by FLEMING, Gini F, BRUNETTO, Virginia L, CELLA, David, LOOK, Katherine Y, REID, Gary C, MUNKARAH, Adnan R, KLINE, Richard, BURGER, Robert A, GOODMAN, Annekathryn, BURKS, R. Tucker

“…To determine whether the addition of paclitaxel to doxorubicin plus cisplatin improves overall survival (OS) in women with advanced or recurrent endometrial…”
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Targeting mitochondrial metabolism with CPI-613 in chemoresistant ovarian tumors by Udumula, Mary P., Rashid, Faraz, Singh, Harshit, Pardee, Tim, Luther, Sanjeev, Bhardwaj, Tanya, Anjaly, Km, Piloni, Sofia, Hijaz, Miriana, Gogoi, Radhika, Philip, Philip A., Munkarah, Adnan R., Giri, Shailendra, Rattan, Ramandeep

“…Background There is evidence indicating that chemoresistance in tumor cells is mediated by the reconfiguration of the tricarboxylic acid cycle, leading to…”
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Overexpression of enhancer of zeste homolog 2 (EZH2) and focal adhesion kinase (FAK) in high grade endometrial carcinoma by Zhou, Jun, Roh, Ju-Won, Bandyopadhyay, Sudeshna, Chen, Zhengming, Munkarah, Adnan R, Hussein, Yaser, Alosh, Baraa, Jazaerly, Tarek, Hayek, Kinda, Semaan, Assaad, Sood, Anil K, Ali-Fehmi, Rouba

“…Abstract Objective The deregulation of E-cadherin is associated with Src/FAK signaling axis and histone deacetylase (HDAC)/EZH2 activity. However, the…”
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Trends in the Utilization of Adjuvant Vaginal Cuff Brachytherapy and/or External Beam Radiation Treatment in Stage I and II Endometrial Cancer: A Surveillance, Epidemiology, and End-Results Study by Patel, Mehul K., M.D, Cote, Michele L., Ph.D, Ali-Fehmi, Rouba, M.D, Buekers, Thomas, M.D, Munkarah, Adnan R., M.D, Elshaikh, Mohamed A., M.D

“…Purpose The optimal adjuvant radiation treatment for endometrial carcinoma (EC) remains controversial. Adjuvant vaginal cuff brachytherapy (VB) has emerged as…”
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Ovarian cancer: changes in patterns at diagnosis and relative survival over the last three decades by Barnholtz-Sloan, Jill S, Schwartz, Ann G, Qureshi, Faisal, Jacques, Suzanne, Malone, John, Munkarah, Adnan R

“…The purpose of this study was to examine patterns of diagnosis and relative survival in women who had a diagnosis of primary invasive epithelial ovarian cancer…”
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Modulation of redox signaling promotes apoptosis in epithelial ovarian cancer cells by Jiang, Zhongliang, Fletcher, Nicole M, Ali-Fehmi, Rouba, Diamond, Michael P, Abu-Soud, Husam M, Munkarah, Adnan R, Saed, Ghassan M

“…Abstract Objective Epithelial ovarian cancer (EOC) cells are known to be resistant to apoptosis through a mechanism that may involve alteration in their redox…”
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Impact of microsatellite instability (MSI) on survival in high grade endometrial carcinoma by Arabi, Haitham, Guan, Hui, Kumar, Sanjeev, Cote, Michele, Bandyopadhyay, Sudeshna, Bryant, Christopher, Shah, Jay, Abdul-Karim, Fadi W, Munkarah, Adnan R, Ali-Fehmi, Rouba

“…Abstract Objective Although microstellite instability (MSI) is a prognostic marker in colorectal cancer, it's relation with prognosis in the endometrial cancer…”
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Sensitization of ovarian cancer cells to cisplatin by genistein: the role of NF-kappaB by Solomon, Leigh A, Ali, Shadan, Banerjee, Sanjeev, Munkarah, Adnan R, Morris, Robert T, Sarkar, Fazlul H

“…Platinum-resistance (PR) continues to be a major problem in the management of epithelial ovarian cancer (EOC). Response to various chemotherapeutic agents is…”
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Isatin Derived Spirocyclic Analogues with α‑Methylene-γ-butyrolactone as Anticancer Agents: A Structure–Activity Relationship Study by Rana, Sandeep, Blowers, Elizabeth C, Tebbe, Calvin, Contreras, Jacob I, Radhakrishnan, Prakash, Kizhake, Smitha, Zhou, Tian, Rajule, Rajkumar N, Arnst, Jamie L, Munkarah, Adnan R, Rattan, Ramandeep, Natarajan, Amarnath

“…Design, synthesis, and evaluation of α-methylene-γ-butyrolactone analogues and their evaluation as anticancer agents is described. SAR identified a spirocyclic…”
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Prognostic impact of marital status on survival of women with epithelial ovarian cancer by Mahdi, Haider, Kumar, Sanjeev, Munkarah, Adnan R., Abdalamir, Moshrik, Doherty, Mark, Swensen, Ron

“…Objectives The objective of this study is to examine the impact of marital status on survival of patients with epithelial ovarian cancer (EOC). Methods…”
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Synergistic effect of MEK inhibitor and metformin combination in low grade serous ovarian cancer by Mert, Ismail, Chhina, Jasdeep, Allo, Ghassan, Dai, Jing, Seward, Shelly, Carey, Mark S., Llaurado, Marta, Giri, Shailendra, Rattan, Ramandeep, Munkarah, Adnan R.

“…•Metformin inhibits LGSOC cells.•Trametinib inhibits LGSOC with RAS mutation.•Synergistic effect of Metformin and Trametinib depends on RAS…”
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The role of adjuvant therapy in stage IA serous and clear cell uterine cancer: A multi-institutional pooled analysis by Qu, X. Melody, Velker, Vikram M., Leung, Eric, Kwon, Janice S., Elshaikh, Mohamed A., Kong, Iwa, Logie, Natalie A., Mendez, Lucas C., van der Putten, Louis J., Donovan, Elysia K., Munkarah, Adnan R., Wiebe, Ericka M., Parra-Herran, Carlos, Warner, Andrew, Louie, Alexander V., D'Souza, David P.

“…As the optimal adjuvant management of stage IA serous or clear cell endometrial cancer is controversial, a multi-institutional review was conducted with the…”
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Recurrence patterns and survival endpoints in women with stage II uterine endometrioid carcinoma: A multi-institution study by Elshaikh, Mohamed A, Al-Wahab, Zaid, Mahdi, Haider, Albuquerque, Kevin, Mahan, Meredith, Kehoe, Siobhan M, Ali-Fehmi, Rouba, Rose, Peter G, Munkarah, Adnan R

“…Abstract Objective There is paucity of data in regard to prognostic factors and outcome of women with 2009 FIGO stage II disease. The objective of this study…”
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Divergent Metabolic Effects of Metformin Merge to Enhance Eicosapentaenoic Acid Metabolism and Inhibit Ovarian Cancer In Vivo by Udumula, Mary P, Poisson, Laila M, Dutta, Indrani, Tiwari, Nivedita, Kim, Seongho, Chinna-Shankar, Jasdeep, Allo, Ghassan, Sakr, Sharif, Hijaz, Miriana, Munkarah, Adnan R, Giri, Shailendra, Rattan, Ramandeep

“…Metformin is being actively repurposed for the treatment of gynecologic malignancies including ovarian cancer. We investigated if metformin induces analogous…”
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Tumor size is an independent predictor of lymph node metastasis and survival in early stage endometrioid endometrial cancer by Mahdi, Haider, Munkarah, Adnan R., Ali-Fehmi, Rouba, Woessner, Jessica, Shah, Shetal N., Moslemi-Kebria, Mehdi

“…Objective(s) To analyze the impact of tumor size (TS) on risk of lymph node metastasis (PLN) and prognosis in endometrioid endometrial cancer grossly confined…”
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Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction by Al-Wahab, Zaid, Mert, Ismail, Tebbe, Calvin, Chhina, Jasdeep, Hijaz, Miriana, Morris, Robert T, Ali-Fehmi, Rouba, Giri, Shailendra, Munkarah, Adnan R, Rattan, Ramandeep

“…Caloric restriction (CR) was recently demonstrated by us to restrict ovarian cancer growth in vivo. CR resulted in activation of energy regulating enzymes…”
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External pelvic and vaginal irradiation vs. vaginal irradiation alone as postoperative therapy in women with early stage uterine serous carcinoma: Results of a National Cancer Database analysis by Modh, Ankit, Burmeister, Charlotte, Munkarah, Adnan R., Elshaikh, Mohamed A.

“…Adjuvant treatment in early stage uterine serous carcinoma (USC) usually consists of chemotherapy with vaginal brachytherapy (VB), pelvic external beam…”
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Expression of GLUT-1 in epithelial ovarian carcinoma: Correlation with tumor cell proliferation, angiogenesis, survival and ability to predict optimal cytoreduction by Semaan, Assaad, Munkarah, Adnan R, Arabi, Haitham, Bandyopadhyay, Sudeshna, Seward, Shelly, Kumar, Sanjeev, Qazi, Aamer, Hussein, Yasser, Morris, Robert T, Ali-Fehmi, Rouba

“…Abstract Objective GLUT-1 is involved at various steps in the processes of tumor progression. The objective of this study was to examine the relationship…”
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