Search Results - "Munje, Chinmay"

CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy by Kinstrie, Ross, Horne, Gillian A., Morrison, Heather, Irvine, David, Munje, Chinmay, Castañeda, Eduardo Gómez, Moka, Hothri A., Dunn, Karen, Cassels, Jennifer E., Parry, Narissa, Clarke, Cassie J., Scott, Mary T., Clark, Richard E., Holyoake, Tessa L., Wheadon, Helen, Copland, Mhairi

“…The introduction of BCR-ABL tyrosine kinase inhibitors has revolutionized the treatment of chronic myeloid leukemia (CML). A major clinical aim remains the…”
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Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia by Alanazi, Bader, Munje, Chinmay R., Rastogi, Namrata, Williamson, Andrew J. K., Taylor, Samuel, Hole, Paul S., Hodges, Marie, Doyle, Michelle, Baker, Sarah, Gilkes, Amanda F., Knapper, Steven, Pierce, Andrew, Whetton, Anthony D., Darley, Richard L., Tonks, Alex

“…Inappropriate localization of proteins can interfere with normal cellular function and drive tumor development. To understand how this contributes to the…”
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Correction: CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy by Kinstrie, Ross, Horne, Gillian A., Morrison, Heather, Irvine, David, Munje, Chinmay, Castañeda, Eduardo Gómez, Moka, Hothri A., Dunn, Karen, Cassels, Jennifer E., Parry, Narissa, Clarke, Cassie J., Scott, Mary T., Clark, Richard E., Holyoake, Tessa L., Wheadon, Helen, Copland, Mhairi

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling by Hole, Paul S., Zabkiewicz, Joanna, Munje, Chinmay, Newton, Zarabeth, Pearn, Lorna, White, Paul, Marquez, Nuria, Hills, Robert K., Burnett, Alan K., Tonks, Alex, Darley, Richard L.

“…Excessive production of reactive oxygen species (ROS) is frequently observed in cancer and is known to strongly influence hematopoietic cell function. Here we…”
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Gene Expression Profiling of CD93-Selected CP-CML Stem Cells Confirms Their Quiescent Character and Biomarker Potential by Horne, Gillian A., Munje, Chinmay Rajiv, Kinstrie, Ross, Gómez-Castañeda, Eduardo, Wheadon, Helen, Copland, Mhairi

“…The introduction of BCR-ABL tyrosine kinase inhibitors has revolutionized the treatment of chronic myeloid leukemia (CML). A major clinical aim remains the…”
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The Spliceosome: A New Therapeutic Target in Chronic Myeloid Leukaemia by Lebecque, Benjamin, Bourgne, Celine, Munje, Chinmay, Berger, Juliette, Tassin, Thomas, Cony-Makhoul, Pascale, Guerci-Bresler, Agnès, Johnson-Ansah, Hyacinthe, Liu, Wei, Saugues, Sandrine, Tchirkov, Andrei, Vetrie, David, Copland, Mhairi, Berger, Marc G

“…RNA splicing factors are frequently altered in cancer and can act as both oncoproteins and tumour suppressors. They have been found mutated or deregulated,…”
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The Complexity of Identifying Cancer Stem Cell Biomarkers by Khan, Zarine, Shervington, Amal, Munje, Chinmay, Shervington, Leroy

“…The efficacy of glioma therapy can be considerably improved if it eliminates cancer stem cells (CSCs); however, to achieve this, CSCs markers are required…”
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Tyrosine Kinase Inhibitor Independent Gene Expression Signature in CML Offers New Targets for LSPC Eradication Therapy by Gómez-Castañeda, Eduardo, Hopcroft, Lisa E. M, Rogers, Simon, Munje, Chinmay, Bittencourt-Silvestre, Joana, Copland, Mhairi, Vetrie, David, Holyoake, Tessa, Jørgensen, Heather G

“…Tyrosine kinase inhibitors (TKI) have revolutionised the treatment of CML. However, TKI do not eliminate the leukaemia stem cells (LSC), which can re-initiate…”
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A Subpopulation of Blasts with Attenuated p38MAPK Response Is Seen in Virtually All AML Patients and AML Cell Lines and Is Defined By Cells with Augmented Lipid-Associated Anti-Oxidant Defense by Hole, Paul S., Davies, Sara, Munje, Chinmay R, Kreuser, Sandra, Hills, Robert K., Omidvar, Nader, Knapper, Steven, Burnett, Alan K., Tonks, Alex, Darley, Richard L.

“…The serine/ threonine kinase, p38MAPK is activated by phosphorylation in response to a variety of cellular stresses including oxidative stress. Prolonged…”
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Integrated Nuclear Proteomics and Transcriptomics Identifies New High Frequency Dysregulated Transcription Factors in AML by Munje, Chinmay R, Williamson, Andrew J.K., Taylor, Samuel, Hills, Robert K., Knapper, Steven, Burnett, Alan K., Pierce, Andrew, Whetton, Anthony, Darley, Richard L., Tonks, Alex

“…Acute myeloid leukemia (AML) is characterized by developmental arrest which is thought to arise from transcriptional dysregulation of myeloid development…”
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A Novel Therapeutic Strategy for the Treatment of Glioma, Combining Chemical and Molecular Targeting of Hsp90α by Mehta, Adi, Shervington, Leroy, Munje, Chinmay, Shervington, Amal

“…Hsp90α's vital role in tumour survival and progression, together with its highly inducible expression profile in gliomas and its absence in normal tissue and…”
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Can hsp90α-Targeted siRNA Combined With TMZ Be a Future Therapy for Glioma? by Cruickshanks, Nichola, Shervington, Leroy, Patel, Rahima, Munje, Chinmay, Thakkar, Dipti, Shervington, Amal

“…ABSTRACT Hsp90α's vital role in cell cycle progression and apoptosis together with its presence in gliomas and absence in normal tissue, make it a credible…”
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Cord Blood-Derived Quiescent CD34 super(+) Cells Are More Transcriptionally Matched to AML Blasts Than Cytokine-Induced Normal Human Hematopoietic CD34 super(+) Cells by Munje, Chinmay, Hills, Robert K, Whetton, Anthony, Burnett, Alan K, Darley, Richard L, Tonks, Alex

“…Acute myeloid leukemia (AML) is characterized by developmental arrest, which is thought to arise from transcriptional dysregulation of myeloid development…”
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A novel therapeutic strategy for the treatment of glioma, combining chemical and molecular targeting of hsp90a by Mehta, Adi, Shervington, Leroy, Munje, Chinmay, Shervington, Amal

“…Hsp90a's vital role in tumour survival and progression, together with its highly inducible expression profile in gliomas and its absence in normal tissue and…”
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Cord Blood-Derived Quiescent CD34+ Cells Are More Transcriptionally Matched to AML Blasts Than Cytokine-Induced Normal Human Hematopoietic CD34+ Cells by Munje, Chinmay, Hills, Robert K., Whetton, Anthony, Burnett, Alan K., Darley, Richard L., Tonks, Alex

“…Acute myeloid leukemia (AML) is characterized by developmental arrest, which is thought to arise from transcriptional dysregulation of myeloid development…”
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Hsp90 as a molecular target by Munje, Chinmay

“…Heat shock protein 90 (Hsp90), a highly conserved molecular chaperone, has been proposed to play a vital role in tumorigenesis. Hsp90 has two isoforms, of…”
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Can hsp90alpha-targeted siRNA combined with TMZ be a future therapy for glioma? by Cruickshanks, Nichola, Shervington, Leroy, Patel, Rahima, Munje, Chinmay, Thakkar, Dipti, Shervington, Amal

“…Hsp90alpha's vital role in cell cycle progression and apoptosis together with its presence in gliomas and absence in normal tissue, make it a credible target…”
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