Search Results - "Mundy, W R"

Age-related changes in reactive oxygen species production in rat brain homogenates by Driver, Amy S., Kodavanti, Prasada Rao S., Mundy, William R.

“…The generation of reactive oxygen species (ROS) and resultant oxidative stress have been implicated in the mechanism of brain dysfunction due to age-related…”
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Accumulation of methylmercury or polychlorinated biphenyls in in vitro models of rat neuronal tissue by Meacham, C.A., Freudenrich, T.M., Anderson, W.L., Sui, L., Lyons-Darden, T., Barone, S., Gilbert, M.E., Mundy, W.R., Shafer, T.J.

“…In vivo exposure levels for neurotoxicants are often reported in parts per million (ppm) concentration in tissue, whereas exposure levels in experiments…”
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Spatial learning and long-term potentiation in the dentate gyrus of the hippocampus in animals developmentally exposed to Aroclor 1254 by GILBERT, M. E, MUNDY, W. R, CROFTON, K. M

“…Developmental exposure to polychlorinated biphenyls (PCBs) has been associated with cognitive deficits in children. Rodent studies have revealed impairments in…”
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Effects of methylmercury and mercuric chloride on differentiation and cell viability in PC12 cells by PARRAN, D. K, MUNDY, W. R, BARONE, S. JR

“…The effects of methylmercury (CH3Hg) or mercuric chloride (HgCl(2)) on neurite outgrowth and cell viability were quantified using undifferentiated (unprimed)…”
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Accumulation of PBDE-47 in Primary Cultures of Rat Neocortical Cells by Mundy, William R., Freudenrich, Theresa M., Crofton, Kevin M., DeVito, Michael J.

“…A number of recent studies have examined the neurotoxic actions of polybrominated diphenyl ethers (PBDEs) using in vitro cell culture models. However, there…”
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Developmental exposure of rats to a reconstituted PCB mixture or aroclor 1254: Effects on long-term potentiation and [3H]MK-801 binding in occipital cortex and hippocampus by ALTMANN, L, MUNDY, W. R, WARD, T. R, FASTABEND, A, LILIENTHAL, H

“…The central nervous system is one of the target organs for polychlorinated biphenyls (PCBs). We measured the effects of maternal exposure of Long-Evans rats to…”
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Sensitivity of immature neurons in culture to metal-induced changes in reactive oxygen species and intracellular free calcium by Mundy, W R, Freudenrich, T M

“…It is widely recognized that prolonged increases in reactive oxygen species (ROS) and intracellular free calcium ([Ca2+]i) are part of a signaling pathway…”
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Congener-Specific Distribution of Polychlorinated Biphenyls in Brain Regions, Blood, Liver, and Fat of Adult Rats Following Repeated Exposure to Aroclor 1254 by Kodavanti, Prasada Rao S., Ward, Thomas R., Derr-Yellin, Ethel C., Mundy, William R., Casey, Ann C., Bush, Brian, Tilson, Hugh A.

“…Our previousin vitrostudies with both isolated organelles and primary neuronal cell cultures found that intracellular signal transduction can be perturbed by…”
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Organophosphorus compounds preferentially affect second messenger systems coupled to M2/M4 receptors in rat frontal cortex by Ward, Thomas R., Mundy, William R.

“…Recent reports indicate that organophosphate insecticides, in addition to inhibiting acetylcholinesterase activity, can bind directly at a subset of muscarinic…”
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Identification of calcium-dependent and -independent signaling pathways involved in polychlorinated biphenyl-induced cyclic AMP-responsive element-binding protein phosphorylation in developing cortical neurons by Inglefield, J.R, Mundy, W.R, Meacham, C.A, Shafer, T.J

“…Cyclic AMP (cAMP)-responsive element-binding protein (CREB) is a transcription factor important in developing nervous system cells and is activated by a…”
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Extracellular calcium is required for the polychlorinated biphenyl-induced increase of intracellular free calcium levels in cerebellar granule cell culture by Mundy, William R., Shafer, Timothy J., Tilson, Hugh A., Kodavanti, Prasada Rao S.

“…Recent studies from the laboratory indicate that polychlorinated biphenyl (PCB) congeners can alter signal transduction and calcium homeostasis in neuronal…”
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Repeated Exposure of Adult Rats to Aroclor 1254 Causes Brain Region-Specific Changes in Intracellular Ca2+Buffering and Protein Kinase C Activity in the Absence of Changes in Tyrosine Hydroxylase by Kodavanti, Prasada Rao S., Derr-Yellin, Ethel C., Mundy, William R., Shafer, Timothy J., Herr, David W., Barone, Stanley, Choksi, Neepa Y., MacPhail, Robert C., Tilson, Hugh A.

“…Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants, some of which may be neurotoxic.In vitrostudies from this laboratory indicated that…”
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Differential effects of polychlorinated biphenyl congeners on phosphoinositide hydrolysis and protein kinase C translocation in rat cerebellar granule cells by Kodavanti, P R, Shafer, T J, Ward, T R, Mundy, W R, Freudenrich, T, Harry, G J, Tilson, H A

“…Previous reports from our laboratory have suggested that the neuroactivity of some polychlorinated biphenyl (PCB) congeners is associated with perturbations in…”
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Disruption of Inositol Phosphate Accumulation in Cerebellar Granule Cells by Polychlorinated Biphenyls: A Consequence of Altered Ca2+Homeostasis by Shafer, Timothy J., Mundy, William R., Tilson, Hugh A., Kodavanti, Prasada Rao S.

“…The present study examined the activation of protein kinase C (PKC) and disruption of Ca2+homeostasis as potential mechanisms underlying effects of the…”
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Neurotoxic effects of colchicine by Mundy, W R, Tilson, H A

“…Neurotoxicants have found increasing use as tools to study the structure and function of the central nervous system. One class of compounds which block mitosis…”
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Neurotransmitter concentrations and binding at dopamine receptors in rats after maternal exposure to 3,4,3′,4′-tetrachlorobiphenyl: the role of reduced thyroid hormone concentrations by Roth-Härer, Astrid, Lilienthal, Hellmuth, Bubser, Michael, Kronthaler, Ulrich, R. Mundy, William, R. Ward, Thomas, Schmidt, Werner, Winterhoff, Hilke, Winneke, Gerhard

“…Polychlorinated biphenyls (PCBs) are environmental contaminants, which accumulate in the food chain and are transferred to the offspring during prenatal…”
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Correlation of the anticholinesterase activity of a series of organophosphates with their ability to compete with agonist binding to muscarinic receptors by Ward, T R, Ferris, D J, Tilson, H A, Mundy, W R

“…Some compounds that inhibit acetylcholinesterase (AChE) activity compete directly with quinuclidinyl benzilate (QNB) binding, a muscarinic antagonist which…”
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Neurotoxic effects of neonatal triethyltin (TET) exposure are exacerbated with aging by Barone, Stanley, Stanton, Mark E., Mundy, William R.

“…Neonatal Long-Evans rats dosed with TET (5 mg/kg; IP) or saline on postnatal day (PND) 10 were examined across the life span for neural damage and performance…”
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Time course of changes in cholinergic and neurotrophin-related markers after infusion of colchicine into the basal forebrain by Shaughnessy, Laura W, Mundy, William R, Tilson, Hugh A, Barone, Stanley

“…After bilateral infusions of colchicine or vehicle in the rat nucleus basalis magnocellularis, the time course of changes in several cholinergic and…”
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In vitro aluminum inhibition of brain phosphoinositide metabolism: comparison of neonatal and adult rats by Mundy, W R, Freudenrich, T, Shafer, T J, Nostrandt, A C

“…Recent evidence indicates that the neurotoxic metal aluminum interferes with the phosphoinositide second messenger system in adult rats both in vitro and in…”
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