Search Results - "Mundinger, Thomas O"

Minireview: The Role of the Autonomic Nervous System in Mediating the Glucagon Response to Hypoglycemia by Taborsky, Gerald J, Mundinger, Thomas O

“…In type 1 diabetes, the impairment of the glucagon response to hypoglycemia increases both its severity and duration. In nondiabetic individuals, hypoglycemia…”
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Human Type 1 Diabetes Is Characterized by an Early, Marked, Sustained, and Islet-Selective Loss of Sympathetic Nerves by Mundinger, Thomas O, Mei, Qi, Foulis, Alan K, Fligner, Corinne L, Hull, Rebecca L, Taborsky, Jr, Gerald J

“…In humans, the glucagon response to moderate-to-marked insulin-induced hypoglycemia (IIH) is largely mediated by the autonomic nervous system. Because this…”
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SGLT2-i improves markers of islet endothelial cell function in db/db diabetic mice by Hogan, Meghan F, Hackney, Daryl J, Aplin, Alfred C, Mundinger, Thomas O, Larmore, Megan J, Castillo, Joseph J, Esser, Nathalie, Zraika, Sakeneh, Hull, Rebecca L

“…Islet endothelial cells produce paracrine factors important for islet beta-cell function and survival. Under conditions of type 2 diabetes, islet endothelial…”
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Sympathetic Innervation of Interscapular Brown Adipose Tissue Is Not a Predominant Mediator of Oxytocin-Induced Brown Adipose Tissue Thermogenesis in Female High Fat Diet-Fed Rats by Dodson, Andrew D, Herbertson, Adam J, Honeycutt, Mackenzie K, Vered, Ron, Slattery, Jared D, Goldberg, Matvey, Tsui, Edison, Wolden-Hanson, Tami, Graham, James L, Wietecha, Tomasz A, O'Brien, Kevin D, Havel, Peter J, Sikkema, Carl L, Peskind, Elaine R, Mundinger, Thomas O, Taborsky, Jr, Gerald J, Blevins, James E

“…Recent studies have indicated that hindbrain [fourth ventricle (4V)] administration of the neurohypophyseal hormone, oxytocin (OT), reduces body weight, energy…”
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Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of oxytocin-elicited reductions of body weight and adiposity in male diet-induced obese mice by Edwards, Melise M, Nguyen, Ha K, Dodson, Andrew D, Herbertson, Adam J, Wolden-Hanson, Tami, Wietecha, Tomasz A, Honeycutt, Mackenzie K, Slattery, Jared D, O'Brien, Kevin D, Graham, James L, Havel, Peter J, Mundinger, Thomas O, Sikkema, Carl L, Peskind, Elaine R, Ryu, Vitaly, Taborsky, Jr, Gerald J, Blevins, James E

“…Previous studies indicate that CNS administration of oxytocin (OT) reduces body weight in high fat diet-induced obese (DIO) rodents by reducing food intake and…”
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Direct Stimulation of Ghrelin Secretion by Sympathetic Nerves by Mundinger, Thomas O, Cummings, David E, Taborsky, Gerald J

“…The hormone ghrelin is secreted mainly from the gut, rises in peripheral plasma before meals, and is implicated in stimulating hunger, initiating meals, and…”
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Acute Inhibition of Intestinal Neprilysin Enhances Insulin Secretion via GLP-1 Receptor Signaling in Male Mice by Esser, Nathalie, Mundinger, Thomas O, Barrow, Breanne M, Zraika, Sakeneh

“…Abstract The peptidase neprilysin modulates glucose homeostasis by cleaving and inactivating insulinotropic peptides, including some produced in the intestine…”
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Glucose intolerance induced by blockade of central FGF receptors is linked to an acute stress response by Rojas, Jennifer M, Matsen, Miles E, Mundinger, Thomas O, Morton, Gregory J, Stefanovski, Darko, Bergman, Richard N, Kaiyala, Karl J, Taborsky, Gerald J, Schwartz, Michael W

“…Abstract Objective Central administration of ligands for fibroblast growth factor receptors (FGFRs) such as fibroblast growth factor-19 (FGF19) and FGF21 exert…”
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Neprilysin deficiency reduces hepatic gluconeogenesis in high fat-fed mice by Esser, Nathalie, Mongovin, Stephen M, Mundinger, Thomas O, Barrow, Breanne M, Zraika, Sakeneh

“…Neprilysin is a peptidase that cleaves glucoregulatory peptides, including glucagon-like peptide-1 (GLP-1) and cholecystokinin (CCK). Some studies suggest that…”
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Early, Selective, and Marked Loss of Sympathetic Nerves From the Islets of BioBreeder Diabetic Rats by Mei, Qi, Mundinger, Thomas O, Lernmark, Ake, Taborsky, Jr, Gerald J

“…Early, Selective, and Marked Loss of Sympathetic Nerves From the Islets of BioBreeder Diabetic Rats Qi Mei , Thomas O. Mundinger , Ake Lernmark and Gerald J…”
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Early sympathetic islet neuropathy in autoimmune diabetes: lessons learned and opportunities for investigation by Mundinger, Thomas O., Taborsky, Gerald J.

“…This review outlines the current state of knowledge regarding a unique neural defect of the pancreatic islet in autoimmune diabetes, one that we have termed…”
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Neprilysin inhibition improves intravenous but not oral glucose-mediated insulin secretion via GLP-1R signaling in mice with β -cell dysfunction by Esser, Nathalie, Mongovin, Stephen M, Parilla, Jacqueline, Barrow, Breanne M, Mundinger, Thomas O, Fountaine, Brendy S, Larmore, Megan J, Castillo, Joseph J, Akter, Rehana, Hull, Rebecca L, Zraika, Sakeneh

“…Type 2 diabetes is associated with the upregulation of neprilysin, a peptidase capable of cleaving glucoregulatory peptides such as glucagon-like peptide-1…”
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Co-impairment of autonomic and glucagon responses to insulin-induced hypoglycemia in dogs with naturally occurring insulin-dependent diabetes mellitus by Gilor, Chen, Duesberg, Cynthia, Elliott, Denise A, Feldman, Edward C, Mundinger, Thomas O, Taborsky, Jr, Gerald J, Nelson, Richard W, Havel, Peter J

“…This study aimed to investigate the contributions of two factors potentially impairing glucagon response to insulin-induced hypoglycemia (IIH) in…”
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Short-term diabetic hyperglycemia suppresses celiac ganglia neurotransmission, thereby impairing sympathetically mediated glucagon responses by Mundinger, Thomas O, Cooper, Ellis, Coleman, Michael P, Taborsky, Jr, Gerald J

“…Short-term hyperglycemia suppresses superior cervical ganglia neurotransmission. If this ganglionic dysfunction also occurs in the islet sympathetic pathway,…”
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Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: effect of early sympathetic islet neuropathy by Mundinger, Thomas O, Mei, Qi, Figlewicz, Dianne P, Lernmark, Ake, Taborsky, Jr, Gerald J

“…We investigated the functional impact of a recently described islet-specific loss of sympathetic nerves that occurs soon after the autoimmune destruction of…”
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The p75 Neurotrophin Receptor Is Required for the Major Loss of Sympathetic Nerves From Islets Under Autoimmune Attack by TABORSKY, Gerald J, QI MEI, BORNFELDT, Karin E, HACKNEY, Daryl J, MUNDINGER, Thomas O

“…Our goal was to determine the role of the p75 neurotrophin receptor (p75NTR) in the loss of islet sympathetic nerves that occurs during the autoimmune attack…”
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Parasympathetic inhibition of sympathetic neural activity to the pancreas by Benthem, L, Mundinger, T O, Taborsky, Jr, G J

“…The present study tested the hypothesis that activation of the parasympathetic nervous system could attenuate sympathetic activation to the pancreas. To test…”
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Increased galanin expression in the celiac ganglion of BB diabetic rats by Mei, Qi, Mundinger, Thomas O, Lernmark, Åke, Taborsky, Gerald J.

“…BB rats lose >50% of their islet sympathetic nerve terminals soon after diabetes onset, markedly impairing the glucagon response to activation of these nerves…”
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Impaired activation of celiac ganglion neurons in vivo after damage to their sympathetic nerve terminals by Mundinger, Thomas O., Mei, Qi, Taborsky Jr, Gerald J.

“…Because damage to sympathetic nerve terminals occurs in a variety of diseases, we tested the hypothesis that nerve terminal damage per se is sufficient to…”
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Meal-induced insulin secretion in dogs is mediated by both branches of the autonomic nervous system by Benthem, L, Mundinger, T O, Taborsky, Jr, G J

“…We investigated the relationship between autonomic activity to the pancreas and insulin secretion in chronically catheterized dogs when food was shown, during…”
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