Search Results - "Mundell, S. J"

Platelet dysfunction associated with the novel Trp29Cys thromboxane A2 receptor variant by Mumford, A. D., Nisar, S., Darnige, L., Jones, M. L., Bachelot‐Loza, C., Gandrille, S., Zinzindohoue, F., Fischer, A.‐M., Mundell, S. J., Gaussem, P.

“…Summary Background Genetic variations that affect the structure of the thromboxane A2 receptor (TP receptor) provide insights into the function of this key…”
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Internalization and Desensitization of the Oxytocin Receptor Is Inhibited by Dynamin and Clathrin Mutants in Human Embryonic Kidney 293 Cells by Smith, M. P, Ayad, V. J, Mundell, S. J, McArdle, C. A, Kelly, E, López Bernal, A

“…Oxytocin (OT) has long been used as an uterotonic during labor management in women, and yet responses to OT infusion remain variable and unpredictable among…”
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Deletion of the distal COOH‐terminus of the A2B adenosine receptor switches internalization to an arrestin‐ and clathrin‐independent pathway and inhibits recycling by Mundell, SJ, Matharu, A‐L, Nisar, S, Palmer, TM, Benovic, JL, Kelly, E

“…Background and purpose:  We have investigated the effect of deletions of a postsynaptic density, disc large and zo‐1 protein (PDZ) motif at the end of the…”
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Receptor homodimerization plays a critical role in a novel dominant negative P2RY12 variant identified in a family with severe bleeding by Mundell, S. J., Rabbolini, D., Gabrielli, S., Chen, Q., Aungraheeta, R., Hutchinson, J. L., Kilo, T., Mackay, J., Ward, C. M., Stevenson, W., Morel‐Kopp, M.‐C.

“…Essentials Three dominant variants for the autosomal recessive bleeding disorder type‐8 have been described. To date, there has been no phenotype/genotype…”
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A novel mutation in the P2Y12 receptor and a function‐reducing polymorphism in protease‐activated receptor 1 in a patient with chronic bleeding by Patel, Y. M., Lordkipanidzé, M., Lowe, G. C., Nisar, S. P., Garner, K., Stockley, J., Daly, M. E., Mitchell, M., Watson, S. P., Austin, S. K., Mundell, S. J.

“…Summary Background The study of patients with bleeding problems is a powerful approach in determining the function and regulation of important proteins in…”
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Rare platelet GPCR variants: what can we learn? by Nisar, S P, Jones, M L, Cunningham, M R, Mumford, A D, Mundell, S J

“…Platelet‐expressed GPCRs are critical regulators of platelet function. Pharmacological blockade of these receptors forms a powerful therapeutic tool in the…”
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Morphine‐induced internalization of the L83I mutant of the rat μ‐opioid receptor by Cooke, A E, Oldfield, S, Krasel, C, Mundell, S J, Henderson, G, Kelly, E

“…Background and Purpose Naturally occurring single‐nucleotide polymorphisms (SNPs) within GPCRs can result in alterations in various pharmacological parameters…”
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Rapid genetic diagnosis of heritable platelet function disorders with next‐generation sequencing: proof‐of‐principle with Hermansky–Pudlak syndrome by JONES, M. L., MURDEN, S. L., BEM, D., MUNDELL, S. J., GISSEN, P., DALY, M. E., WATSON, S. P., MUMFORD, A. D.

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Regulation of G Protein-Coupled Receptor-Adenylyl Cyclase Responsiveness in Human Airway Smooth Muscle by Exogenous and Autocrine Adenosine by Mundell, Stuart J, Olah, Mark E, Panettieri, Reynold A., Jr, Benovic, Jeffrey L, Penn, Raymond B

“…Adenosine is a mediator of bronchoconstriction in asthmatics and is believed to mediate its effects through adenosine receptor activation in inflammatory…”
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Rapid resensitization of purinergic receptor function in human platelets by MUNDELL, S. J., BARTON, J. F., MAYO‐MARTIN, M. B., HARDY, A. R., POOLE, A. W.

“…Background: Adenosine diphosphate (ADP) is a critical regulator of platelet activation, mediating its actions through two G protein‐coupled receptors (GPCRs),…”
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Reciprocal regulation of platelet responses to P2Y and thromboxane receptor activation by BARTON, J. F., HARDY, A. R., POOLE, A. W., MUNDELL, S. J.

“…Background: Thromboxane A2 and ADP are two major platelet agonists that stimulate two sets of G protein‐coupled receptors to activate platelets. Although…”
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Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization by Orsini, M J, Parent, J L, Mundell, S J, Marchese, A, Benovic, J L

“…The G protein-coupled chemokine receptor CXCR4 serves as the primary coreceptor for entry of T-cell tropic human immunodeficiency virus. CXCR4 undergoes tonic…”
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Deletion of the distal COOH‐terminus of the A 2B adenosine receptor switches internalization to an arrestin‐ and clathrin‐independent pathway and inhibits recycling by Mundell, SJ, Matharu, A‐L, Nisar, S, Palmer, TM, Benovic, JL, Kelly, E

“…Background and purpose:  We have investigated the effect of deletions of a postsynaptic density, disc large and zo‐1 protein (PDZ) motif at the end of the…”
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Selective Regulation of Endogenous G Protein-coupled Receptors by Arrestins in HEK293 Cells by Mundell, Stuart J., Benovic, Jeffrey L.

“…Arrestins play an important role in regulating desensitization and trafficking of G protein-coupled receptors (GPCRs). However, limited insight into the…”
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Agonist‐induced internalization of the metabotropic glutamate receptor 1a is arrestin‐ and dynamin‐dependent by Mundell, Stuart J., Matharu, Anne‐Lise, Pula, Giordano, Roberts, Peter J., Kelly, Eamonn

“…At present, little is known regarding the mechanism of metabotropic glutamate receptor (mGluR) trafficking. To facilitate this characterization we inserted a…”
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Rapid agonist-induced desensitization and internalization of the A(2B) adenosine receptor is mediated by a serine residue close to the COOH terminus by Matharu, A L, Mundell, S J, Benovic, J L, Kelly, E

“…The G(s)-coupled rat A(2B) adenosine receptor (A(2B)-AR) was epitope-tagged at the NH(2) terminus with hemagglutinin (HA) and subjected to progressive…”
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Arrestin Specificity for G Protein-coupled Receptors in Human Airway Smooth Muscle by Penn, R B, Pascual, R M, Kim, Y M, Mundell, S J, Krymskaya, V P, Panettieri, Jr, R A, Benovic, J L

“…Despite a widely accepted role of arrestins as “uncouplers” of G protein-coupled receptor (GPCR) signaling, few studies have demonstrated the ability of…”
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Characterization of G Protein-Coupled Receptor Regulation in Antisense mRNA-Expressing Cells with Reduced Arrestin Levels by Mundell, Stuart J, Loudon, Robert P, Benovic, Jeffrey L

“…Previous studies with overexpressing wild-type or dominant negative nonvisual arrestins have established a role for these proteins in β2-adrenergic receptor…”
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The effect of inhibitors of receptor internalization on the desensitization and resensitization of three Gs‐coupled receptor responses by Mundell, Stuart J, Kelly, Eamonn

“…Many G protein‐coupled receptors (GPCRs) are known to internalize following agonist exposure, however the relative importance of this mechanism for the…”
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Evidence for co-expression and desensitization of A2a and A2b adenosine receptors in NG108-15 cells by MUNDELL, S. J, KELLY, E

“…Using receptor-selective agonists and antagonists, the possible presence of both A2a and A2b adenosine receptor subtypes coupled to activation of adenylyl…”
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