Search Results - "Mundell, Cary"

Engineered viral RNA decay intermediates to assess XRN1-mediated decay by Russo, Joseph, Mundell, Cary T., Charley, Phillida A., Wilusz, Carol, Wilusz, Jeffrey

“…[Display omitted] •An XRN1 stall site is engineered as a convenient read out for RNA decay.•We demonstrate a synthetic stem loop structure that can stall…”
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The Role of Lysosomes in a Broad Disease-Modifying Approach Evaluated across Transgenic Mouse Models of Alzheimer's Disease and Parkinson's Disease and Models of Mild Cognitive Impairment by Hwang, Jeannie, Estick, Candice M, Ikonne, Uzoma S, Butler, David, Pait, Morgan C, Elliott, Lyndsie H, Ruiz, Sarah, Smith, Kaitlan, Rentschler, Katherine M, Mundell, Cary, Almeida, Michael F, Stumbling Bear, Nicole, Locklear, James P, Abumohsen, Yara, Ivey, Cecily M, Farizatto, Karen L G, Bahr, Ben A

“…Many neurodegenerative disorders have lysosomal impediments, and the list of proposed treatments targeting lysosomes is growing. We investigated the role of…”
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Development of Cathepsin B Positive Modulators to Treat Multi‐Proteinopathic Dementias: Exploiting the Lysosomal Avenue of Protein Clearance to Promote Synaptic Recovery by Pait, Morgan C, Elliott, Lyndsie, Hafner‐Ruiz, Sarah, Mundell, Cary, Patterson, Walter, Romine, Heather, Ikonne, Uzoma, Bahr, Ben A.

“…Abstract only Alzheimer's disease (AD) is characterized by pathological assembly states of Aβ42, tau aggregates, and other age‐related protein accumulations…”
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Assessing and Understanding The Generation and Function of RNA Decay Intermediates in Non-Insect Borne Flaviviruses by Mundell, Cary T

“…Cellular gene expression is an intricate process regulated on many levels that allows the cell to react correctly to stimuli or to maintain homeostasis. RNA…”
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