Search Results - "Mundel, Peter"

Cell biology and pathology of podocytes by Greka, Anna, Mundel, Peter

“…As an integral member of the filtration barrier in the kidney glomerulus, the podocyte is in a unique geographical position: It is exposed to chemical signals…”
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Podocyte-Targeted Treatment for Proteinuric Kidney Disease by Mundel, Peter, MD

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Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton by Faul, Christian, Asanuma, Katsuhiko, Yanagida-Asanuma, Etsuko, Kim, Kwanghee, Mundel, Peter

“…Podocytes of the renal glomerulus are unique cells with a complex cellular organization consisting of a cell body, major processes and foot processes. Podocyte…”
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Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53 by Yoon, Kyoung Wan, Byun, Sanguine, Kwon, Eunjeong, Hwang, So-Young, Chu, Kiki, Hiraki, Masatsugu, Jo, Seung-Hee, Weins, Astrid, Hakroush, Samy, Cebulla, Angelika, Sykes, David B., Greka, Anna, Mundel, Peter, Fisher, David E., Mandinova, Anna, Lee, Sam W.

“…The inefficient clearance of dying cells can lead to abnormal immune responses, such as unresolved inflammation and autoimmune conditions. We show that tumor…”
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Abatacept in B7-1–Positive Proteinuric Kidney Disease by Yu, Chih-Chuan, Fornoni, Alessia, Weins, Astrid, Hakroush, Samy, Maiguel, Dony, Sageshima, Junichiro, Chen, Linda, Ciancio, Gaetano, Faridi, Mohd. Hafeez, Behr, Daniel, Campbell, Kirk N, Chang, Jer-Ming, Chen, Hung-Chun, Oh, Jun, Faul, Christian, Arnaout, M. Amin, Fiorina, Paolo, Gupta, Vineet, Greka, Anna, Burke, George W, Mundel, Peter

“…This report describes five patients with treatment-resistant focal segmental glomerulosclerosis and positive B7-1 immunostaining who had a response to…”
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The role of podocytes in glomerular pathobiology by Asanuma, Katsuhiko, Mundel, Peter

“…Podocytes are unique cells with a complex cellular organization. With respect to their cytoarchitecture, podocytes may be divided into three structurally and…”
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Role of Podocyte B7-1 in Diabetic Nephropathy by FIORINA, Paolo, VERGANI, Andrea, MATTINZOLI, Deborah, IKEHATA, Masami, CORRADI, Domenico, SCHUMACHER, Valerie, BUVALL, Lisa, YU, Chih-Chuan, CHANG, Jer-Ming, LA ROSA, Stefano, FINZI, Giovanna, SOLINI, Anna, BASSI, Roberto, VINCENTI, Flavio, RASTALDI, Maria Pia, REISER, Jochen, KROLEWSKI, Andrzej S, MUNDEL, Peter H, SAYEGH, Mohamed H, NIEWCZAS, Monika A, ALTINTAS, Mehmet M, PEZZOLESI, Marcus G, D'ADDIO, Francesca, CHIN, Melissa, TEZZA, Sara, BEN NASR, Moufida

“…Podocyte injury and resulting albuminuria are hallmarks of diabetic nephropathy, but targeted therapies to halt or prevent these complications are currently…”
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The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A by Donnelly, Mary, Merscher-Gomez, Sandra, Chang, Jer-Ming, Reiser, Jochen, Campbell, Kirk N, Mundel, Peter, Faul, Christian, Choi, Hoon Young, Delfgaauw, Jacqueline, Chang, Yoon Hee, Franz, Stefan, Kim, Kwanghee

“…Currently, there are few options for treating chronic kidney disease. The immunosuppressant cyclosporine A is effective, but the mechanism has been unclear. In…”
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Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes by Brouwers, Olaf, Niessen, Petra M. G., Miyata, Toshio, Østergaard, Jakob A., Flyvbjerg, Allan, Peutz-Kootstra, Carine J., Sieber, Jonas, Mundel, Peter H., Brownlee, Michael, Janssen, Ben J. A., De Mey, Jo G. R., Stehouwer, Coen D. A., Schalkwijk, Casper G.

“…Aims/hypothesis In diabetes, advanced glycation end-products (AGEs) and the AGE precursor methylglyoxal (MGO) are associated with endothelial dysfunction and…”
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Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids by Sieber, Jonas, Lindenmeyer, Maja Tamara, Kampe, Kapil, Campbell, Kirk Nicholas, Cohen, Clemens David, Hopfer, Helmut, Mundel, Peter, Jehle, Andreas Werner

“…Apoptosis of podocytes is considered critical in the pathogenesis of diabetic nephropathy (DN). Free fatty acids (FFAs) are critically involved in the…”
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Podocyte-Selective Deletion of Dicer Induces Proteinuria and Glomerulosclerosis by SHAOLIN SHI, LIPING YU, BOTTINGER, Erwin P, CHIU, Celine, YEZHOU SUN, JIN CHEN, KHITROV, Greg, MERKENSCHLAGER, Matthias, HOLZMAN, Lawrence B, WEIJIA ZHANG, MUNDEL, Peter

“…Dicer is an enzyme that generates microRNA (miRNA), which are small, noncoding RNA that function as important regulators of gene and protein expression. For…”
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Synaptopodin Is a Coincidence Detector of Tyrosine versus Serine/Threonine Phosphorylation for the Modulation of Rho Protein Crosstalk in Podocytes by Buvall, Lisa, Wallentin, Hanna, Sieber, Jonas, Andreeva, Svetlana, Choi, Hoon Young, Mundel, Peter, Greka, Anna

“…Tyrosine and serine/threonine signal-transduction pathways influence many aspects of cell behavior, including the spatial and temporal regulation of the actin…”
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Calcium Regulates Podocyte Actin Dynamics by Greka, Anna, MD, PhD, Mundel, Peter, MD

“…Summary Ca2+ -mediated remodeling of the actin cytoskeleton is a dynamic process that regulates cell motility through the modulation of rho guanosine…”
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Balancing Calcium Signals through TRPC5 and TRPC6 in Podocytes by GREKA, Anna, MUNDEL, Peter

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Modification of kidney barrier function by the urokinase receptor by Zacchigna, Serena, Xie, Liang, Schmid, Holger, Bendayan, Moïse, Mundel, Peter, Li, Jing, Rastaldi, Maria P, Kretzler, Matthias, Henger, Anna, Altintas, Mehmet M, Nikolic, Boris, Reiser, Jochen, Schwarz, Karin, Cowan, Peter, Parrilla, Roberto, Möller, Clemens C, Wei, Changli, Carmeliet, Peter, Gupta, Vineet, Kalluri, Raghu

“…Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at…”
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Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2 by Kampe, Kapil, Sieber, Jonas, Orellana, Jana Marina, Mundel, Peter, Jehle, Andreas Werner

“…Type 2 diabetes is characterized by dyslipidemia with elevated free fatty acids (FFAs). Loss of podocytes is a hallmark of diabetic nephropathy, and podocytes…”
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Yes-associated Protein (YAP) Promotes Cell Survival by Inhibiting Proapoptotic Dendrin Signaling by Campbell, Kirk N., Wong, Jenny S., Gupta, Ritu, Asanuma, Katsuhiko, Sudol, Marius, He, John Cijiang, Mundel, Peter

“…Kidney podocytes are highly specialized terminally differentiated cells that form the final barrier to urinary protein loss. Podocytes are a target for injury…”
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Glomerulosclerosis Induced by Deficiency of Membrane-Associated Guanylate Kinase Inverted 2 in Kidney Podocytes by Shirata, Naritoshi, Ihara, Kan-Ichiro, Yamamoto-Nonaka, Kanae, Seki, Takuto, Makino, Shin-Ichi, Oliva Trejo, Juan Alejandro, Miyake, Takafumi, Yamada, Hiroyuki, Campbell, Kirk Nicholas, Nakagawa, Takahiko, Mori, Kiyoshi, Yanagita, Motoko, Mundel, Peter, Nishimori, Katsuhiko, Asanuma, Katsuhiko

“…Membrane-associated guanylate kinase inverted 2 (MAGI-2) is a component of the slit diaphragm (SD) of glomerular podocytes. Here, we investigated the…”
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TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function by Reiser, Jochen, Pollak, Martin R, Polu, Krishna R, Möller, Clemens C, Kenlan, Peter, Altintas, Mehmet M, Wei, Changli, Faul, Christian, Herbert, Stephanie, Villegas, Ivan, Avila-Casado, Carmen, McGee, Mary, Sugimoto, Hikaru, Brown, Dennis, Kalluri, Raghu, Mundel, Peter, Smith, Paula L, Clapham, David E

“…Progressive kidney failure is a genetically and clinically heterogeneous group of disorders. Podocyte foot processes and the interposed glomerular slit…”
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MAGI-2 scaffold protein is critical for kidney barrier function by Balbas, Minna D., Burgess, Michael R., Murali, Rajmohan, Wongvipat, John, Skaggs, Brian J., Mundel, Peter, Weins, Astrid, Sawyers, Charles L.

“…Significance MAGUK Inverted 2 (MAGI-2) is a scaffold protein with a putative tumor-suppressor role and also interacts with nephrin in the glomerular slit…”
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