Search Results - "Mund, Thomas"

Peptide and small molecule inhibitors of HECT-type ubiquitin ligases by Mund, Thomas, Lewis, Michael J., Maslen, Sarah, Pelham, Hugh R.

“…The human genome encodes several hundred E3 ubiquitin ligases containing RING domains, and around 28 containing HECT domains. These enzymes catalyze the…”
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Ubiquitination of alpha-synuclein filaments by Nedd4 ligases by Mund, Thomas, Masuda-Suzukake, Masami, Goedert, Michel, Pelham, Hugh R

“…Alpha-synuclein can form beta-sheet filaments, the accumulation of which plays a key role in the development of Parkinson's disease, dementia with Lewy bodies…”
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Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins by Mund, Thomas, Pelham, Hugh R B

“…HECT domain E3 ubiquitin ligases of the NEDD4 family control many cellular processes, but their regulation is poorly understood. They contain multiple WW…”
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Cdk-Inhibitory Activity and Stability of p27 Are Directly Regulated by Oncogenic Tyrosine Kinases by Grimmler, Matthias, Wang, Yuefeng, Mund, Thomas, Cilenšek, Zoran, Keidel, Eva-Maria, Waddell, M. Brett, Jäkel, Heidelinde, Kullmann, Michael, Kriwacki, Richard W., Hengst, Ludger

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Activity‐Based Probes for HECT E3 Ubiquitin Ligases by Byrne, Robert, Mund, Thomas, Licchesi, Julien D. F.

“…Activity‐based probes (ABPs) have been used to dissect the biochemical/structural properties and cellular functions of deubiquitinases. However, their utility…”
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Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2 by Mund, Thomas, Pelham, Hugh R. B., Brugge, Joan S.

“…Ndfip1 and Ndfip2 are related endosomal membrane proteins that bind to and activate members of the Nedd4 family of E3 ubiquitin ligases. These ligases in turn…”
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Towards accurate exclusion of neonatal bacterial meningitis: a feasibility study of a novel 16S rDNA PCR assay by Abelian, Arthur, Mund, Thomas, Curran, Martin D, Savill, Stuart A, Mitra, Nipa, Charan, Carol, Ogilvy-Stuart, Amanda L, Pelham, Hugh R. B, Dear, Paul H

“…Abstract Background PCRctic is an innovative assay based on 16S rDNA PCR technology that has been designed to detect a single intact bacterium in a specimen of…”
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Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled by Mund, Thomas, Graeb, Michael, Mieszczanek, Juliusz, Gammons, Melissa, Pelham, Hugh R. B., Bienz, Mariann

“…Dishevelled is a pivot in Wnt signal transduction, controlling both β-catenin-dependent transcription to specify proliferative cell fates, and cell polarity…”
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The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction by Albayrak, Timur, Scherhammer, Volker, Schoenfeld, Nicole, Braziulis, Erik, Mund, Thomas, Bauer, Manuel K A, Scheffler, Immo E, Grimm, Stefan

“…A genetic screen was established to clone apoptosis-inducing genes in a high-throughput format. It led to the isolation of several proapoptotic genes whose…”
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Substrate clustering potently regulates the activity of WW-HECT domain–containing ubiquitin ligases by Mund, Thomas, Pelham, Hugh R.

“…The Nedd4 family of HECT domain–containing E3 ligases ubiquitinate many transcription factors and signaling proteins, and their activity is tightly regulated…”
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Local statin therapy differentially interferes with smooth muscle and endothelial cell proliferation and reduces neointima on a drug-eluting stent platform by JASCHKE, Birgit, MICHAELIS, Cornelia, MILZ, Stefan, VOGESER, Michael, MUND, Thomas, HENGST, Ludger, KASTRATI, Adnan, SCHÖMIG, Albert, WESSELY, Rainer

“…Therapeutic strategies to provide local inhibition of mitogen mediated proliferation and migration of human coronary artery smooth muscle cells (CASMC) by…”
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Spike, a novel BH3‐only protein, regulates apoptosis at the endoplasmic reticulum by Mund, Thomas, Gewies, Andreas, Schoenfeld, Nicole, Bauer, Manuel K.A., Grimm, Stefan

“…ABSTRACT We have isolated Spike, a novel and evolutionary conserved BH3‐only protein. BH3‐only proteins constitute a family of apoptosis inducers that mediate…”
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Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases by Grimmler, Matthias, Wang, Yuefeng, Mund, Thomas, Cilensek, Zoran, Keidel, Eva-Maria, Waddell, M Brett, Jäkel, Heidelinde, Kullmann, Michael, Kriwacki, Richard W, Hengst, Ludger

“…p27Kip1 controls cell proliferation by binding to and regulating the activity of cyclin-dependent kinases (Cdks). Here we show that Cdk inhibition and p27…”
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Cdk-Inhibitory Activity and Stability of p27 Kip1 Are Directly Regulated by Oncogenic Tyrosine Kinases by Grimmler, Matthias, Wang, Yuefeng, Mund, Thomas, Cilenšek, Zoran, Keidel, Eva-Maria, Waddell, M. Brett, Jäkel, Heidelinde, Kullmann, Michael, Kriwacki, Richard W., Hengst, Ludger

“…p27 Kip1 controls cell proliferation by binding to and regulating the activity of cyclin-dependent kinases (Cdks). Here we show that Cdk inhibition and p27…”
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Cdk-Inhibitory Activity and Stability of p27 super(Kip1) Are Directly Regulated by Oncogenic Tyrosine Kinases by Grimmler, Matthias, Wang, Yuefeng, Mund, Thomas, Cilensek, Zoran, Keidel, Eva-Maria, Waddell, MBrett, Jaekel, Heidelinde, Kullmann, Michael, Kriwacki, Richard W, Hengst, Ludger

“…p27 super(Kip1) controls cell proliferation by binding to and regulating the activity of cyclin-dependent kinases (Cdks). Here we show that Cdk inhibition and…”
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Purification and assays of vasodilator-stimulated phosphoprotein by Jarchau, T, Mund, T, Reinhard, M, Walter, U

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