Search Results - "Munaza Ahmed"

The avoiding late diagnosis of ovarian cancer (ALDO) project; a pilot national surveillance programme for women with pathogenic germline variants in BRCA1 and BRCA2 by Philpott, Sue, Raikou, Maria, Manchanda, Ranjit, Lockley, Michelle, Singh, Naveena, Scott, Malcolm, Evans, D Gareth, Adlard, Julian, Ahmed, Munaza, Edmondson, Richard, Woodward, Emma Roisin, Lamnisos, Athena, Balega, Janos, Brady, Angela F, Sharma, Aarti, Izatt, Louise, Kulkarni, Anjana, Tripathi, Vishakha, Solomons, Joyce S, Hayes, Kevin, Hanson, Helen, Snape, Katie, Side, Lucy, Skates, Steve, McGuire, Alistair, Rosenthal, Adam N

“…Our study aimed to establish 'real-world' performance and cost-effectiveness of ovarian cancer (OC) surveillance in women with pathogenic germline variants who…”
Get more information

ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles by Rahman, Nazneen, Renwick, Anthony, Thompson, Deborah, Seal, Sheila, Kelly, Patrick, Chagtai, Tasnim, Ahmed, Munaza, North, Bernard, Jayatilake, Hiran, Barfoot, Rita, Spanova, Katarina, McGuffog, Lesley, Evans, D Gareth, Eccles, Diana, Easton, Douglas F, Stratton, Michael R

“…We screened individuals from 443 familial breast cancer pedigrees and 521 controls for ATM sequence variants and identified 12 mutations in affected…”
Get full text

Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles by Rahman, Nazneen, Seal, Sheila, Thompson, Deborah, Renwick, Anthony, Elliott, Anna, Kelly, Patrick, Barfoot, Rita, Chagtai, Tasnim, Jayatilake, Hiran, Ahmed, Munaza, Spanova, Katarina, North, Bernard, McGuffog, Lesley, Evans, D Gareth, Eccles, Diana, Easton, Douglas F, Stratton, Michael R

“…We identified constitutional truncating mutations of the BRCA1-interacting helicase BRIP1 in 9/1,212 individuals with breast cancer from BRCA1/BRCA2…”
Get full text

Patient decision aids in mainstreaming genetic testing for women with ovarian cancer: A prospective cohort study by Sobocan, Monika, Chandrasekaran, Dhivya, Sideris, Michail, Blyuss, Oleg, Fierheller, Caitlin, Kalra, Ashwin, Sia, Jacqueline, Miller, Rowan E., Mills‐Baldock, Tina, Crusz, Shanthini M., Sun, Li, Evans, Olivia, Robbani, Sadiyah, Jenkins, Lucy A., Ahmed, Munaza, Kumar, Ajith, Quigley, Mary, Lockley, Michelle, Faruqi, Asma, Casey, Laura, Brockbank, Elly, Phadnis, Saurabh, Trevisan, Giorgia, Singh, Naveena, Legood, Rosa, Manchanda, Ranjit

“…Objective To evaluate patient preference for short (gist) or detailed/extensive decision aids (DA) for genetic testing at ovarian cancer (OC) diagnosis. Design…”
Get full text

UK consensus recommendations for clinical management of cancer risk for women with germline pathogenic variants in cancer predisposition genes: RAD51C , RAD51D , BRIP1 and PALB2 by Hanson, Helen, Kulkarni, Anjana, Loong, Lucy, Kavanaugh, Grace, Torr, Bethany, Allen, Sophie, Ahmed, Munaza, Antoniou, Antonis C, Cleaver, Ruth, Dabir, Tabib, Evans, D Gareth, Golightly, Ellen, Jewell, Rosalyn, Kohut, Kelly, Manchanda, Ranjit, Murray, Alex, Murray, Jennie, Ong, Kai-Ren, Rosenthal, Adam N, Woodward, Emma Roisin, Eccles, Diana M, Turnbull, Clare, Tischkowitz, Marc, Lalloo, Fiona

“…Germline pathogenic variants (GPVs) in the cancer predisposition genes , , , , , , , and are identified in approximately 15% of patients with ovarian cancer…”
Get more information

Decision making for health‐related research outcomes that alter diagnosis: A model from paediatric brain tumours by Pickles, Jessica C., Aquilina, Kristian, Chalker, Jane, Dahl, Christine, Devadass, Abel, Mankad, Kshitij, Merve, Ashirwad, Ahmed, Munaza, Nicoll, James A. R., Bloom, Tabitha, Hilton, David A., Sebire, Neil J., Hargrave, Darren, Jacques, Thomas S.

“…Aims The question of how to handle clinically actionable outcomes from retrospective research studies is poorly explored. In neuropathology, this problem is…”
Get full text

Population Study of Ovarian Cancer Risk Prediction for Targeted Screening and Prevention by Gaba, Faiza, Blyuss, Oleg, Liu, Xinting, Goyal, Shivam, Lahoti, Nishant, Chandrasekaran, Dhivya, Kurzer, Margarida, Kalsi, Jatinderpal, Sanderson, Saskia, Lanceley, Anne, Ahmed, Munaza, Side, Lucy, Gentry-Maharaj, Aleksandra, Wallis, Yvonne, Wallace, Andrew, Waller, Jo, Luccarini, Craig, Yang, Xin, Dennis, Joe, Dunning, Alison, Lee, Andrew, Antoniou, Antonis C, Legood, Rosa, Menon, Usha, Jacobs, Ian, Manchanda, Ranjit

“…Unselected population-based personalised ovarian cancer (OC) risk assessment combining genetic/epidemiology/hormonal data has not previously been undertaken…”
Get full text

Implementation of Multigene Germline and Parallel Somatic Genetic Testing in Epithelial Ovarian Cancer: SIGNPOST Study by Chandrasekaran, Dhivya, Sobocan, Monika, Blyuss, Oleg, Miller, Rowan E., Evans, Olivia, Crusz, Shanthini M., Mills-Baldock, Tina, Sun, Li, Hammond, Rory F. L., Gaba, Faiza, Jenkins, Lucy A., Ahmed, Munaza, Kumar, Ajith, Jeyarajah, Arjun, Lawrence, Alexandra C., Brockbank, Elly, Phadnis, Saurabh, Quigley, Mary, El Khouly, Fatima, Wuntakal, Rekha, Faruqi, Asma, Trevisan, Giorgia, Casey, Laura, Burghel, George J., Schlecht, Helene, Bulman, Michael, Smith, Philip, Bowers, Naomi L., Legood, Rosa, Lockley, Michelle, Wallace, Andrew, Singh, Naveena, Evans, D. Gareth, Manchanda, Ranjit

“…We present findings of a cancer multidisciplinary-team (MDT) coordinated mainstreaming pathway of unselected 5-panel germline BRCA1/BRCA2/RAD51C/RAD51D/BRIP1…”
Get full text

Sporadic implementation of UK familial mammographic surveillance guidelines 15 years after original publication by Evans, D. Gareth, Edwards, Maria, Duffy, Stephen W., Tischkowitz, Marc

“…The National Institute of health and Care Excellence issued guidelines on familial breast cancer screening in 2004. Such guidelines should be uniformly…”
Get full text

Unselected Population Genetic Testing for Personalised Ovarian Cancer Risk Prediction: A Qualitative Study Using Semi-Structured Interviews by Gaba, Faiza, Oxley, Samuel, Liu, Xinting, Yang, Xin, Chandrasekaran, Dhivya, Kalsi, Jatinderpal, Antoniou, Antonis, Side, Lucy, Sanderson, Saskia, Waller, Jo, Ahmed, Munaza, Wallace, Andrew, Wallis, Yvonne, Menon, Usha, Jacobs, Ian, Legood, Rosa, Marks, Dalya, Manchanda, Ranjit

“…Unselected population-based personalised ovarian cancer (OC) risk assessments combining genetic, epidemiological and hormonal data have not previously been…”
Get full text

Rothmund–Thomson Syndrome: novel pathogenic mutations and frequencies of variants in the RECQL 4 and USB 1 (C16orf57) gene by Suter, Aude‐Annick, Itin, Peter, Heinimann, Karl, Ahmed, Munaza, Ashraf, Tazeen, Fryssira, Helen, Kini, Usha, Lapunzina, Pablo, Miny, Peter, Sommerlund, Mette, Suri, Mohnish, Vaeth, Signe, Vasudevan, Pradeep, Gallati, Sabina

“…Abstract Background Poikiloderma is defined as a chronic skin condition presenting with a combination of punctate atrophy, areas of depigmentation,…”
Get full text

Prostate Cancer Risks for Male BRCA1▪ and BRCA2 Mutation Carriers: A Prospective Cohort Study by Nyberg, Tommy, Frost, Debra, Barrowdale, Daniel, Evans, D. Gareth, Bancroft, Elizabeth, Adlard, Julian, Ahmed, Munaza, Barwell, Julian, Brady, Angela F., Brewer, Carole, Cook, Jackie, Davidson, Rosemarie, Donaldson, Alan, Eason, Jacqueline, Gregory, Helen, Henderson, Alex, Izatt, Louise, Kennedy, M. John, Miller, Claire, Morrison, Patrick J., Murray, Alex, Ong, Kai-Ren, Porteous, Mary, Pottinger, Caroline, Rogers, Mark T., Side, Lucy, Snape, Katie, Walker, Lisa, Tischkowitz, Marc, Eeles, Rosalind, Easton, Douglas F., Antoniou, Antonis C.

“…BRCA1 and BRCA2 mutations have been associated with prostate cancer (PCa) risk but a wide range of risk estimates have been reported that are based on…”
Get full text

Benefits for children with suspected cancer from routine whole-genome sequencing by Hodder, Angus, Leiter, Sarah M., Kennedy, Jonathan, Addy, Dilys, Ahmed, Munaza, Ajithkumar, Thankamma, Allinson, Kieren, Ancliff, Phil, Bailey, Shivani, Barnard, Gemma, Burke, G. A. Amos, Burns, Charlotte, Cano-Flanagan, Julian, Chalker, Jane, Coleman, Nicholas, Cheng, Danny, Clinch, Yasmin, Dryden, Caryl, Ghorashian, Sara, Griffin, Blanche, Horan, Gail, Hubank, Michael, May, Phillippa, McDerra, Joanna, Nagrecha, Rajvi, Nicholson, James, O’Connor, David, Pavasovic, Vesna, Quaegebeur, Annelies, Rao, Anupama, Roberts, Thomas, Samarasinghe, Sujith, Stasevich, Iryna, Tadross, John A., Trayers, Claire, Trotman, Jamie, Vora, Ajay, Watkins, James, Chitty, Lyn S., Bowdin, Sarah, Armstrong, Ruth, Murray, Matthew J., Hook, Catherine E., Tarpey, Patrick, Vedi, Aditi, Bartram, Jack, Behjati, Sam

“…Clinical whole-genome sequencing (WGS) has been shown to deliver potential benefits to children with cancer and to alter treatment in high-risk patient groups…”
Get full text

Clinical practice guidelines for the diagnosis and surveillance of BAP1 tumour predisposition syndrome by Lalloo, Fiona, Kulkarni, Anju, Chau, Cindy, Nielsen, Maartje, Sheaff, Michael, Steele, Jeremy, van Doorn, Remco, Wadt, Karin, Hamill, Monica, Torr, Beth, Tischkowitz, Marc, Hanson, Helen

“…BRCA1-associated protein-1 (BAP1) is a recognised tumour suppressor gene. Germline BAP1 pathogenic/likely pathogenic variants are associated with…”
Get full text

Surgical decision making in premenopausal BRCA carriers considering risk-reducing early salpingectomy or salpingo-oophorectomy: a qualitative study by Gaba, Faiza, Goyal, Shivam, Marks, Dalya, Chandrasekaran, Dhivya, Evans, Olivia, Robbani, Sadiyah, Tyson, Charlotte, Legood, Rosa, Saridogan, Ertan, McCluggage, W Glenn, Hanson, Helen, Singh, Naveena, Evans, D Gareth, Menon, Usha, Manchanda, Ranjit

“…Acceptance of the role of the fallopian tube in 'ovarian' carcinogenesis and the detrimental sequelae of surgical menopause in premenopausal women following…”
Get more information

Cost-Effectiveness of Unselected Multigene Germline and Somatic Genetic Testing for Epithelial Ovarian Cancer by Manchanda, Ranjit, Sun, Li, Sobocan, Monika, Rodriguez, Isabel V, Wei, Xia, Kalra, Ashwin, Oxley, Samuel, Sideris, Michail, Fierheller, Caitlin T, Morgan, Robert D, Chandrasekaran, Dhivya, Rust, Kelly, Spiliopoulou, Pavlina, Miller, Rowan E, Crusz, Shanthini M, Lockley, Michelle, Singh, Naveena, Faruqi, Asma, Casey, Laura, Brockbank, Elly, Phadnis, Saurabh, Mills-Baldock, Tina, El-Khouly, Fatima, Jenkins, Lucy A, Wallace, Andrew, Ahmed, Munaza, Kumar, Ajith, Swisher, Elizabeth M, Gourley, Charlie, Norquist, Barbara M, Evans, D Gareth, Legood, Rosa

“…Parallel panel germline and somatic genetic testing of all patients with ovarian cancer (OC) can identify more pathogenic variants (PVs) that would benefit…”
Get more information

Surveillance recommendations for DICER1 pathogenic variant carriers: a report from the SIOPE Host Genome Working Group and CanGene-CanVar Clinical Guideline Working Group by Bakhuizen, Jette J., Hanson, Helen, van der Tuin, Karin, Lalloo, Fiona, Tischkowitz, Marc, Wadt, Karin, Jongmans, Marjolijn C. J.

“…DICER1 syndrome is a rare genetic disorder that predisposes to a wide spectrum of tumors. Developing surveillance protocols for this syndrome is challenging…”
Get full text

Prostate Cancer Risk by BRCA2 Genomic Regions by Nyberg, Tommy, Frost, Debra, Barrowdale, Daniel, Evans, D. Gareth, Bancroft, Elizabeth, Adlard, Julian, Ahmed, Munaza, Barwell, Julian, Brady, Angela F., Brewer, Carole, Cook, Jackie, Davidson, Rosemarie, Donaldson, Alan, Eason, Jacqueline, Gregory, Helen, Henderson, Alex, Izatt, Louise, Kennedy, M. John, Miller, Claire, Morrison, Patrick J., Murray, Alex, Ong, Kai-Ren, Porteous, Mary, Pottinger, Caroline, Rogers, Mark T., Side, Lucy, Snape, Katie, Tripathi, Vishakha, Walker, Lisa, Tischkowitz, Marc, Eeles, Rosalind, Easton, Douglas F., Antoniou, Antonis C.

“…A BRCA2 prostate cancer cluster region (PCCR) was recently proposed (c.7914 to 3′) wherein pathogenic variants (PVs) are associated with higher prostate cancer…”
Get full text

Oral contraceptive use and ovarian cancer risk for BRCA1/2 mutation carriers: an international cohort study by Schrijver, Lieske, Antoniou, Antonis, Olsson, Håkan, Mooij, Thea, Roos-Blom, Marie-José, Azarang, Leyla, Adlard, Julian, Ahmed, Munaza, Barrowdale, Daniel, Davidson, Rosemarie, Donaldson, Alan, Eeles, Ros, Evans, D. Gareth, Frost, Debra, Henderson, Alex, Izatt, Louise, Ong, Kai-Ren, Bonadona, Valérie, Coupier, Isabelle, Faivre, Laurence, Fricker, Jean-Pierre, Gesta, Paul, van Engelen, Klaartje, Jager, Agnes, Menko, Fred, Mourits, Marian J.E., Singer, Christian, Tan, Yen, Foretova, Lenka, Navratilova, Marie, Schmutzler, Rita, Ellberg, Carolina, Gerdes, Anne-Marie, Caldes, Trinidad, Simard, Jacques, Olah, Edith, Jakubowska, Anna, Rantala, Johanna, Osorio, Ana, Hopper, John, Phillips, Kelly-Anne, Milne, Roger, Beth Terry, Mary, Noguès, Catherine, Engel, Christoph, Kast, Karin, Goldgar, David, van Leeuwen, Flora, Easton, Douglas, Andrieu, Nadine, Rookus, Matti, Noguès, Catherine, Laborde, Lilian, Pontois, Pauline, Breysse, Emanuelle, Berline, Margot, Stoppa-Lyonnet, Dominique, Gauthier-Villars, Marion, Buecher, Bruno, Colas, Chrystelle, Caron, Olivier, Mouret-Fourme, Emmanuelle, Saule, Claire, Lasset, Christine, Dussard, Sophie, Berthet, Pascaline, Luporsi, Elisabeth, Mari, Véronique, Gladieff, Laurence, Chieze-Valéro, Stéphanie, Moretta, Jessica, Sobol, Hagay, Eisinger, François, Popovici, Cornel, Longy, Michel, Grivelli, Louise, Soubrier, Florent, Benusiglio, Patrick, Pujol, Pascal, Corsini, Carole, Morin-Meschin, Marie-Emmanuelle, Lortholary, Alain, Adenis, Claude, Maillez, Audrey, Nguyen, Tan Dat, Delnatte, Capucine, Abadie, Caroline, Tinat, Julie, Tennevet, Isabelle, Maugard, Christine, Bignon, Yves-Jean, Gay Bellile, Mathilde, Penet, Clotilde, Dreyfus, Hélène, Cohen-Haguenauer, Odile, Gilbert, Brigitte, Venat-Bouvet, Laurence, Leroux, Dominique, Legrand, Clémentine, Zattara-Cannoni, Hélène

Get full text

Whole-genome sequencing of patients with rare diseases in a national health system by Turro, Ernest, Astle, William, Megy, Karyn, Gräf, Stefan, Greene, Daniel, Shamardina, Olga, Allen, Hana Lango, Sanchis-Juan, Alba, Frontini, Mattia, Thys, Chantal, Stephens, Jonathan, Mapeta, Rutendo, Burren, Oliver, Downes, Kate, Haimel, Matthias, Tuna, Salih, Deevi, Sri, Aitman, Timothy, Bennett, David, Calleja, Paul, Carss, Keren, Caulfield, Mark, Chinnery, Patrick, Dixon, Peter, Gale, Daniel, James, Roger, Koziell, Ania, Laffan, Michael, Levine, Adam, Maher, Eamonn, Markus, Hugh, Morales, Joannella, Morrell, Nicholas, Mumford, Andrew, Ormondroyd, Elizabeth, Rankin, Stuart, Rendon, Augusto, Richardson, Sylvia, Roberts, Irene, Roy, Noemi, Saleem, Moin, Smith, Kenneth, Stark, Hannah, Tan, Rhea, Themistocleous, Andreas, Thrasher, Adrian, Watkins, Hugh, Webster, Andrew, Wilkins, Martin, Williamson, Catherine, Whitworth, James, Humphray, Sean, Bentley, David, Abbs, Stephen, Abulhoul, Lara, Adlard, Julian, Ahmed, Munaza, Alachkar, Hana, Allsup, David, Almeida-King, Jeff, Ancliff, Philip, Antrobus, Richard, Armstrong, Ruth, Arno, Gavin, Ashford, Sofie, Attwood, Anthony, Aurora, Paul, Babbs, Christian, Bacchelli, Chiara, Bakchoul, Tamam, Banka, Siddharth, Bariana, Tadbir, Barwell, Julian, Batista, Joana, Baxendale, Helen, Beales, Phil, Bierzynska, Agnieszka, Biss, Tina, Bitner-Glindzicz, Maria, Black, Graeme, Bleda, Marta, Blesneac, Iulia, Bockenhauer, Detlef, Bogaard, Harm, Bourne, Christian, Boyce, Sara, Bradley, John, Bragin, Eugene, Breen, Gerome, Brennan, Paul, Brewer, Carole, Brown, Matthew, Browning, Andrew, Browning, Michael, Buchan, Rachel, Buckland, Matthew, Bueser, Teofila, Diz, Carmen Bugarin, Burn, John, Burns, Siobhan

Get full text