Search Results - "Munafo', A."

QCT-based vibrational collisional models applied to nonequilibrium nozzle flows by Munafò, A., Panesi, M., Jaffe, R. L., Colonna, G., Bourdon, A., Magin, T. E.

“…Thermal and chemical nonequilibrium effects are investigated in hypersonic nozzle expanding flows by means of vibrational collisional models. The rate…”
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Application of Item Response Theory to Modeling of Expanded Disability Status Scale in Multiple Sclerosis by Novakovic, A. M., Krekels, E. H. J., Munafo, A., Ueckert, S., Karlsson, M. O.

“…ABSTRACT In this study, we report the development of the first item response theory (IRT) model within a pharmacometrics framework to characterize the disease…”
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Pharmacometric Analysis of the Relationship Between Absolute Lymphocyte Count and Expanded Disability Status Scale and Relapse Rate, Efficacy End Points, in Multiple Sclerosis Trials by Novakovic, A.M., Thorsted, A., Schindler, E., Jönsson, S., Munafo, A., Karlsson, M.O.

“…The aim of this work was to assess the relationship between the absolute lymphocyte count (ALC), and disability (as measured by the Expanded Disability Status…”
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Resistance Development: A Major Piece in the Jigsaw Puzzle of Tumor Size Modeling by Terranova, N, Girard, P, Klinkhardt, U, Munafo, A

“…Mathematical models of tumor size (TS) dynamics and tumor growth inhibition (TGI) need to place more emphasis on resistance development, given its relevant…”
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Intranasal mometasone furoate therapy for allergic rhinitis symptoms and rhinitis-disturbed sleep by Meltzer, Eli O., MD, Munafo, Dominic A., MD, Chung, Weiyuan, MS, Gopalan, Gokul, MD, Varghese, Santosh T., MD

“…Background Allergic rhinitis (AR) and related nasal congestion cause rhinitis-disturbed sleep (RDS). Intranasal corticosteroids reduce nasal congestion and…”
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Pharmacokinetics and immunoglobulin response of subcutaneous and intravenous atacicept in patients with systemic lupus erythematosus by Nestorov, I, Papasouliotis, O, Pena Rossi, C, Munafo, A

“…Atacicept, a recombinant fusion protein of the TACI receptor and human IgG, is an inhibitor of B-Lymphocyte Stimulator (BLyS) and APRIL, potent stimulators of…”
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Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development by Swat, MJ, Moodie, S, Wimalaratne, SM, Kristensen, NR, Lavielle, M, Mari, A, Magni, P, Smith, MK, Bizzotto, R, Pasotti, L, Mezzalana, E, Comets, E, Sarr, C, Terranova, N, Blaudez, E, Chan, P, Chard, J, Chatel, K, Chenel, M, Edwards, D, Franklin, C, Giorgino, T, Glont, M, Girard, P, Grenon, P, Harling, K, Hooker, AC, Kaye, R, Keizer, R, Kloft, C, Kok, JN, Kokash, N, Laibe, C, Laveille, C, Lestini, G, Mentré, F, Munafo, A, Nordgren, R, Nyberg, HB, Parra‐Guillen, ZP, Plan, E, Ribba, B, Smith, G, Trocóniz, IF, Yvon, F, Milligan, PA, Harnisch, L, Karlsson, M, Hermjakob, H, Le Novère, N

“…The lack of a common exchange format for mathematical models in pharmacometrics has been a long‐standing problem. Such a format has the potential to increase…”
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Pharmacokinetics and pharmacodynamics of recombinant human chorionic gonadotrophin in healthy male and female volunteers by Trinchard-Lugan, I, Khan, A, Porchet, HC, Munafo, A

“…The pharmacokinetics and pharmacodynamics of recombinant human chorionic gonadotrophin (rHCG) were investigated in three studies of healthy volunteers. After…”
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Comparative pharmacokinetics and pharmacodynamics of recombinant human interferon beta-1a after intramuscular and subcutaneous administration by Munafo, A., Trinchard-Lugan, I., Nguyen, T.X.Q., Buraglio, M.

“…The pharmacokinetics and pharmacodynamics of recombinant human interferon beta (IFN‐β‐la) were compared after intramuscular administration of two preparations…”
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Experimental Demonstrations of CATL, the Collaborative Autonomy Tasking Layer by van Riet, M.W.G., Alves, J., Arcieri, G., Bazzarello, L., de Sousa, J. Borges, Colin, M., Cormack, A., Dias, P., Dinale, J., Ferri, G., Fioravanti, S., Furfaro, T., Guesdon, M., Horstmann, M., Macias, M., Marshall, B., Morlando, L., Munafo, A., Newsum, V., Pailhas, Y., Payne, M., Petroccia, R., Spears, S., Tesei, A.

“…This paper describes the continued efforts on the development of and experiments conducted with CATL (Collaborative Autonomy Tasking Layer). CATL aims to…”
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Prototropic equilibria in DNA containing one-electron oxidized GC: intra-duplex vs. duplex to solvent deprotonation by Adhikary, Amitava, Kumar, Anil, Munafo, Shawn A, Khanduri, Deepti, Sevilla, Michael D

“…By use of ESR and UV-vis spectral studies, this work identifies the protonation states of one-electron oxidized G:C (viz. G˙+:C, G(N1–H)˙:C(+H+), G(N1–H)˙:C,…”
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Boltzmann rovibrational collisional coarse-grained model for internal energy excitation and dissociation in hypersonic flows by Munafò, A, Panesi, M, Magin, T E

“…A Boltzmann rovibrational collisional coarse-grained model is proposed to reduce a detailed kinetic mechanism database developed at NASA Ames Research Center…”
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Nonequilibrium shock-heated nitrogen flows using a rovibrational state-to-state method by Panesi, M, Munafò, A, Magin, T E, Jaffe, R L

“…A rovibrational collisional model is developed to study the internal energy excitation and dissociation processes behind a strong shock wave in a nitrogen…”
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Recombinant follicle stimulating hormone: development of the first biotechnology product for the treatment of infertility

“…Genes encoding the common gonadotrophin α subunit and follicle stimulating hormone (FSH)-specific β subunit were isolated from a DNA library derived from human…”
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Typhoon at CommsNet13: Experimental experience on AUV navigation and localization by Allotta, B., Bartolini, F., Caiti, A., Costanzi, R., Di Corato, F., Fenucci, D., Gelli, J., Guerrini, P., Monni, N., Munafò, A., Natalini, M., Pugi, L., Ridolfi, A., Potter, J.R.

“…This paper presents two acoustic-based techniques for Autonomous Underwater Vehicle (AUV) navigation within an underwater network of fixed sensors. The…”
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Atacicept in patients with rheumatoid arthritis: Results of a multicenter, phase ib, double‐blind, placebo‐controlled, dose‐escalating, single‐ and repeated‐dose study by Tak, P. P., Thurlings, R. M., Rossier, C., Nestorov, I., Dimic, A., Mircetic, V., Rischmueller, M., Nasonov, E., Shmidt, E., Emery, P., Munafo, A.

“…Objective Atacicept is a recombinant fusion protein that binds and neutralizes B lymphocyte stimulator and a proliferation‐inducing ligand. The purpose of this…”
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Transcatheter edge to edge repair of functional mitral regurgitation as bridge to heart transplantation: 2-years follow up results from MitraBridge international registry by Marcelli, C, Munafo', A R, Estevez-Loureiro, R, Adamo, M, Guerin, P, Arzamendi, D, Ho, E C, Asgar, A, Petronio, A S, Grasso, C, Van Mieghem, N M, Tarantini, G, Potena, L, Saia, F, Godino, C

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CHALLENGES ENTAILED IN MANUFACTURING OF CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS FROM PATIENTS WITH CIRCULATING DISEASE: OVERALL ROBUSTNESS OF THE TCT PROCESS ON THE MILTENYI PRODIGY by Nikiforow, S., Daley, H., Rodriguez, D. Hernandez, Munafo, A., Mason, A., Desai, Z., Geary, J., Silva, M., Sturtevant, O.J., Ritz, J.

“…Background: Most CAR manufacturing starts with CD4/CD8 selection to enable accurate T-cell seeding and viral multiplicity of infection (MOI) and to minimize…”
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Safety, pharmacokinetics and pharmacodynamics of recombinant human tumour necrosis factor-binding protein-1 (Onercept) injected by intravenous, intramuscular and subcutaneous routes into healthy volunteers by Trinchard-Lugan, I, Ho-Nguyen, Q, Bilham, W M, Buraglio, M, Ythier, A, Munafo, A

“…The safety, pharmacokinetics and pharmacodynamics of recombinant human tumour necrosis factor-binding protein-1 (r-hTBP-1, Onercept) were investigated after…”
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Impact of right ventricular dysfunction after MitraClip treatment as a bridge to heart transplantation: insights from the MitraBridge registry by Munafo, A, Scotti, A, Estevez-Loureiro, R, Arzamendi, D, Fam, N.P, Maffeo, D, Adamo, M, Ooms, J.F, Potena, L, Petronio, A.S, Grasso, C, Praz, F, Crimi, G, Saia, F, Godino, C

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