Search Results - "Mun, James J."

Genetic analysis of crawling and swimming locomotory patterns in C. elegans by Pierce-Shimomura, Jonathan T, Chen, Beth L, Mun, James J, Ho, Raymond, Sarkis, Raman, McIntire, Steven L

“…Alternative patterns of neural activity drive different rhythmic locomotory patterns in both invertebrates and mammals. The neuro-molecular mechanisms…”
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Clearance of Pseudomonas aeruginosa from a Healthy Ocular Surface Involves Surfactant Protein D and Is Compromised by Bacterial Elastase in a Murine Null-Infection Model by Mun, James J, Tam, Connie, Kowbel, David, Hawgood, Samuel, Barnett, Mitchell J, Evans, David J, Fleiszig, Suzanne M.J

“…Our previous studies showed that surfactant protein D (SP-D) is present in human tear fluid and that it can protect corneal epithelial cells against bacterial…”
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3D quantitative imaging of unprocessed live tissue reveals epithelial defense against bacterial adhesion and subsequent traversal requires MyD88 by Tam, Connie, LeDue, Jeffrey, Mun, James J, Herzmark, Paul, Robey, Ellen A, Evans, David J, Fleiszig, Suzanne M J

“…While a plethora of in vivo models exist for studying infectious disease and its resolution, few enable factors involved in the maintenance of health to be…”
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Surfactant protein D contributes to ocular defense against Pseudomonas aeruginosa in a murine model of dry eye disease by Heimer, Susan R, Evans, David J, Mun, James J, Stern, Michael E, Fleiszig, Suzanne M J

“…Dry eye disease can cause ocular surface inflammation that disrupts the corneal epithelial barrier. While dry eye patients are known to have an increased risk…”
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Cytokeratins mediate epithelial innate defense through their antimicrobial properties by Tam, Connie, Mun, James J, Evans, David J, Fleiszig, Suzanne M J

“…Epithelial cells express antimicrobial proteins in response to invading pathogens, although little is known regarding epithelial defense mechanisms during…”
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The impact of inoculation parameters on the pathogenesis of contact lens-related infectious keratitis by Tam, Connie, Mun, James J, Evans, David J, Fleiszig, Suzanne M J

“…Contact lens wear predisposes to Pseudomonas aeruginosa keratitis, but the mechanisms involved remain unclear. An in vivo model was used to study lens…”
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Factors impacting corneal epithelial barrier function against Pseudomonas aeruginosa traversal by Alarcon, Irania, Tam, Connie, Mun, James J, LeDue, Jeffrey, Evans, David J, Fleiszig, Suzanne M J

“…Mechanisms determining epithelial resistance versus susceptibility to microbial traversal in vivo remain poorly understood. Here, a novel murine model was used…”
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A novel murine model for contact lens wear reveals clandestine IL-1R dependent corneal parainflammation and susceptibility to microbial keratitis upon inoculation with Pseudomonas aeruginosa by Metruccio, Matteo M.E., Wan, Stephanie J., Horneman, Hart, Kroken, Abby R., Sullivan, Aaron B., Truong, Tan N., Mun, James J., Tam, Connie K.P., Frith, Robin, Welsh, Laurence, George, Melanie D., Morris, Carol A., Evans, David J., Fleiszig, Suzanne M.J.

“…Contact lens wear carries a risk of complications, including corneal infection. Solving these complications has been hindered by limitations of existing animal…”
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Modulation of epithelial immunity by mucosal fluid by Mun, James J., Tam, Connie, Evans, David J., Fleiszig, Suzanne M. J.

“…Mucosal epithelial cells, including those at the ocular surface, resist infection by most microbes in vivo but can be susceptible to microbial virulence in…”
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Pathogenic Phenotype and Genotype of Pseudomonas aeruginosa Isolates from Spontaneous Canine Ocular Infections by Ledbetter, Eric C, Mun, James J, Kowbel, David, Fleiszig, Suzanne M. J

“…This study was designed to determine whether the ability to adversely affect corneal epithelial cell health is a factor common to Pseudomonas aeruginosa…”
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Adenylate cyclase activity of Pseudomonas aeruginosa ExoY can mediate bleb-niche formation in epithelial cells and contributes to virulence by Hritonenko, Victoria, Mun, James J., Tam, Connie, Simon, Nathan C., Barbieri, Joseph T., Evans, David J., Fleiszig, Suzanne M.J.

“…We previously showed that ADP-ribosylation (ADP-r) activity of ExoS, a type III secreted toxin of Pseudomonas aeruginosa, enables bacterial replication in…”
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Cytokeratins mediate epithelial innate defense through their antimicrobial properties by Tam, Connie, Mun, James J, Evans, David J, Fleiszig, Suzanne M.J

“…Epithelial cells express antimicrobial proteins in response to invading pathogens, although little is known regarding epithelial defense mechanisms during…”
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Surfactant Protein D Contributes to Ocular Defense against Pseudomonas aeruginosa in a Murine Model of Dry Eye Disease. e65797 by Heimer, Susan R, Evans, David J, Mun, James J, Stern, Michael E, Fleiszig, Suzanne MJ

“…Dry eye disease can cause ocular surface inflammation that disrupts the corneal epithelial barrier. While dry eye patients are known to have an increased risk…”
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Harnessing the Anti-infective Activity of the Ocular Surface to Prevent Infection by Mun, James J

“…Bacterial keratitis, a common infection in contact lens wearers, can lead to blindness caused by pathogenic and host factors. Seventy percent of bacterial…”
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