Search Results - "Muma, NA"

Transglutaminase Is Linked to Neurodegenerative Diseases by Muma, Nancy A

“…Transglutaminase catalyzes a covalent bond between peptide-bound glutamine residues and either lysine-bound peptide residues or mono- or polyamines. Multiple…”
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Extra-nuclear estrogen receptor GPR30 regulates serotonin function in rat hypothalamus by Xu, H, Qin, S, Carrasco, G.A, Dai, Y, Filardo, E.J, Prossnitz, E.R, Battaglia, G, DonCarlos, L.L, Muma, N.A

“…Abstract Selective serotonin reuptake inhibitors (SSRIs), such as Prozac® , are used to treat mood disorders. SSRIs attenuate (i.e. desensitize) serotonin 1A…”
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GPR30 is necessary for estradiol-induced desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the rat hypothalamus by McAllister, C.E, Creech, R.D, Kimball, P.A, Muma, N.A, Li, Q

“…Summary Estrogen therapy used in combination with selective serotonin reuptake inhibitor (SSRI) treatment improves SSRI efficacy for the treatment of mood…”
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Chronic mild stress induces behavioral and physiological changes, and may alter serotonin 1A receptor function, in male and cycling female rats by GRIPPO, Angela J, SULLIVAN, Nicole R, DAMJANOSKA, Katerina J, CRANE, James W, CARRASCO, Gonzalo A, JU SHI, ZHUO CHEN, GARCIA, Francisca, MUMA, Nancy A, VAN DE KAR, Louis D

“…Interactions among stress, serotonin 1A (5-HT(1A)) receptors, and the hypothalamic-pituitary-adrenocortical (HPA) system have been proposed to influence the…”
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Estradiol induces partial desensitization of serotonin 1A receptor signaling in the paraventricular nucleus of the hypothalamus and alters expression and interaction of RGSZ1and Gαz by Creech, RD, Li, Q, Carrasco, GA, Van de Kar, LD, Muma, NA

“…Hyperactivity of hypothalamic-pituitary mediated hormone responses, such as to stimulation with a serotonin 1A (5-HT 1A ) receptor agonist, are a feature of…”
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Estradiol induces partial desensitization of serotonin 1A receptor signaling in the paraventricular nucleus of the hypothalamus and alters expression and interaction of RGSZ1 and Gαz by Creech, R.D., Li, Q., Carrasco, G.A., Van de Kar, L.D., Muma, N.A.

“…Hyperactivity of hypothalamic–pituitary mediated hormone responses, such as to stimulation with a serotonin 1A (5-HT1A) receptor agonist, are a feature of…”
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Protective Effects of Interrupting the Binding of Calmodulin to Mutant Huntingtin by Dudek, Nichole L, Dai, Ying, Muma, Nancy A

“…There is evidence suggesting that transglutaminase (TG) 2 plays a role in stabilizing monomeric and aggregated huntingtin, thereby contributing to the…”
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A desensitization of hypothalamic 5-HT1A receptors by repeated injections of paroxetine: reduction in the levels of G(i) and G(o) proteins and neuroendocrine responses, but not in the density of 5-HT1A receptors by Li, Q, Muma, N A, Battaglia, G, Van de Kar, L D

“…The aim of the present study was to determine whether the previously observed desensitization of hypothalamic 5-hydroxytryptamine1A (5-HT1A) receptors, during…”
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Tau Protein Is Cross-Linked by Transglutaminase in P301L Tau Transgenic Mice by Halverson, Robyn A, Lewis, Jada, Frausto, Shanti, Hutton, Mike, Muma, Nancy A

“…The microtubule-associated protein tau is highly soluble under physiological conditions. However, in tauopathies, tau protein aggregates into insoluble…”
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Activation of the JAK-STAT pathway by olanzapine is necessary for desensitization of serotonin2A receptor-stimulated phospholipase C signaling in rat frontal cortex but not serotonin2A receptor-stimulated hormone release by Singh, RK, Jia, C., Garcia, F., Carrasco, GA, Battaglia, G., Muma, NA

“…Chronic treatment with olanzapine causes desensitization of serotonin 2A receptor signaling. The purpose of the current study was to further understand the…”
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Transglutaminase Cross-Links in Intranuclear Inclusions in Huntington Disease by ZAINELLI, GINA M, ROSS, CHRISTOPHER A, TRONCOSO, JUAN C, MUMA, NANCY A

“…Cortical and striatal perinuclear cytoplasmic aggregates and intranuclear inclusions of mutant huntingtin are neuropathological hallmarks of Huntington disease…”
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Desensitization of 5-HT1A receptors by 5-HT2A receptors in neuroendocrine neurons in vivo by Zhang, Yahong, Gray, Thackery S, D'Souza, Deborah N, Carrasco, Gonzalo A, Damjanoska, Katerina J, Dudas, Bertalan, Garcia, Francisca, Zainelli, Gina M, Sullivan Hanley, Nicole R, Battaglia, George, Muma, Nancy A, Van de Kar, Louis D

“…An imbalance between serotonin-2A (5-HT2A) and 5-HT1A receptors may underlie several mood disorders. The present studies determined whether 5-HT2A receptors…”
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Evidence That 5-HT2A Receptors in the Hypothalamic Paraventricular Nucleus Mediate Neuroendocrine Responses to (-)DOI by Zhang, Yahong, Damjanoska, Katerina J, Carrasco, Gonzalo A, Dudas, Bertalan, D'Souza, Deborah N, Tetzlaff, Julie, Garcia, Francisca, Hanley, Nicole R. Sullivan, Scripathirathan, Kumar, Petersen, Brett R, Gray, Thackery S, Battaglia, George, Muma, Nancy A, Van de Kar, Louis D

“…The present study determined whether the serotonin2A (5-HT2A) receptors in the hypothalamic paraventricular nucleus mediate the neuroendocrine responses to a…”
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Overexpression of four-repeat tau mRNA isoforms in progressive supranuclear palsy but not in Alzheimer's disease by Chambers, Christopher B., Lee, John M., Troncoso, Juan C., Reich, Stephen, Muma, Nancy A.

“…Perturbations in the microtubule‐associated protein tau occur in several human neurodegenerative diseases. In Alzheimer's disease and progressive supranuclear…”
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Mutant Huntingtin Protein: A Substrate for Transglutaminase 1, 2, and 3 by Zainelli, Gina M, Dudek, Nichole L, Ross, Christopher A, Kim, Soo-Youl, Muma, Nancy A

“…The most prominent neuropathologic hallmarks of Huntington disease (HD) are cortical and striatal perinuclear cytoplasmic aggregates and intranuclear…”
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Calmodulin Regulates Transglutaminase 2 Cross-Linking of Huntingtin by Zainelli, Gina M, Ross, Christopher A, Troncoso, Juan C, Fitzgerald, John K, Muma, Nancy A

“…Striatal and cortical intranuclear inclusions and cytoplasmic aggregates of mutant huntingtin are prominent neuropathological hallmarks of Huntington's disease…”
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Transglutaminase bonds in neurofibrillary tangles and paired helical filament tau early in Alzheimer's disease by Singer, Steven M, Zainelli, Gina M, Norlund, Maryam A, Lee, John M, Muma, Nancy A

“…Transglutaminase-catalyzed ε(γ-glutamyl)lysine cross-links exist in Alzheimer's disease (AD) paired helical filament (PHF) tau protein but not normal soluble…”
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Chronic fluoxetine differentially affects 5-hydroxytryptamine (2A) receptor signaling in frontal cortex, oxytocin- and corticotropin-releasing factor-containing neurons in rat paraventricular nucleus by Damjanoska, K J, Van de Kar, L D, Kindel, G H, Zhang, Y, D'Souza, D N, Garcia, F, Battaglia, G, Muma, N A

“…Differential adaptive changes in serotonin2A [5-hydroxytryptamine (5-HT)2A] receptor signaling during treatment may be one mechanism involved in the latency of…”
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Elevated transglutaminase-induced bonds in PHF tau in Alzheimer's disease by Norlund, Maryam A., M. Lee, John, Zainelli, Gina M., Muma, Nancy A.

“…Transglutaminase-induced ε-(γ-glutamyl)lysine bonds covalently cross-link and polymerize peptides into insoluble high molecular weight protein aggregates…”
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Chronic olanzapine activates the Stat3 signal transduction pathway and alters expression of components of the 5-HT2A receptor signaling system in rat frontal cortex by Muma, N A, Singh, R K, Vercillo, M S, D'Souza, D N, Zemaitaitis, B, Garcia, F, Damjanoska, K J, Zhang, Y, Battaglia, G, Van de Kar, L D

“…The mechanisms underlying desensitization of serotonin 2A (5-HT(2A)) receptor signaling by antagonists are unclear but may involve changes in gene expression…”
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