Search Results - "Mulvihill, M."

Therapeutic potential of monoacylglycerol lipase inhibitors by Mulvihill, Melinda M., Nomura, Daniel K.

“…Marijuana and aspirin have been used for millennia to treat a wide range of maladies including pain and inflammation. Both cannabinoids, like marijuana, that…”
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Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity by Benjamin, Daniel I., Cozzo, Alyssa, Ji, Xiaodan, Roberts, Lindsay S., Louie, Sharon M., Mulvihill, Melinda M., Luo, Kunxin, Nomura, Daniel K.

“…Aberrant lipid metabolism is an established hallmark of cancer cells. In particular, ether lipid levels have been shown to be elevated in tumors, but their…”
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Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy by Dragovich, Peter S, Pillow, Thomas H, Blake, Robert A, Sadowsky, Jack D, Adaligil, Emel, Adhikari, Pragya, Chen, Jinhua, Corr, Nicholas, dela Cruz-Chuh, Josefa, Del Rosario, Geoffrey, Fullerton, Aaron, Hartman, Steven J, Jiang, Fan, Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R, Liu, Liling, Lu, Ying, Mulvihill, Melinda M, Murray, Jeremy M, O’Donohue, Aimee, Rowntree, Rebecca K, Sawyer, William S, Staben, Leanna R, Wai, John, Wang, Jian, Wei, BinQing, Wei, Wentao, Xu, Zijin, Yao, Hui, Yu, Shang-Fan, Zhang, Donglu, Zhang, Hongyan, Zhang, Shenhua, Zhao, Yongxin, Zhou, Hao, Zhu, Xiaoyu

“…Heterobifunctional compounds that direct the ubiquitination of intracellular proteins in a targeted manner via co-opted ubiquitin ligases have enormous…”
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Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties by Dragovich, Peter S, Pillow, Thomas H, Blake, Robert A, Sadowsky, Jack D, Adaligil, Emel, Adhikari, Pragya, Bhakta, Sunil, Blaquiere, Nicole, Chen, Jinhua, dela Cruz-Chuh, Josefa, Gascoigne, Karen E, Hartman, Steven J, He, Mingtao, Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R, Liu, Liang, Liu, Liling, Liu, Qi, Lu, Ying, Meng, Fanwei, Mulvihill, Melinda M, O’Donohue, Aimee, Rowntree, Rebecca K, Staben, Leanna R, Staben, Steven T, Wai, John, Wang, Jian, Wei, BinQing, Wilson, Catherine, Xin, Jianfeng, Xu, Zijin, Yao, Hui, Zhang, Donglu, Zhang, Hongyan, Zhou, Hao, Zhu, Xiaoyu

“…The biological and medicinal impacts of proteolysis-targeting chimeras (PROTACs) and related chimeric molecules that effect intracellular degradation of target…”
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Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling by Goncharov, Tatiana, Hedayati, Stefanie, Mulvihill, Melinda M., Izrael-Tomasevic, Anita, Zobel, Kerry, Jeet, Surinder, Fedorova, Anna V., Eidenschenk, Celine, deVoss, Jason, Yu, Kebing, Shaw, Andrey S., Kirkpatrick, Donald S., Fairbrother, Wayne J., Deshayes, Kurt, Vucic, Domagoj

“…Inflammatory responses mediated by NOD2 rely on RIP2 kinase and ubiquitin ligase XIAP for the activation of nuclear factor κB (NF-κB), mitogen-activated…”
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Correction of Both NBD1 Energetics and Domain Interface Is Required to Restore ΔF508 CFTR Folding and Function by Rabeh, Wael M., Bossard, Florian, Xu, Haijin, Okiyoneda, Tsukasa, Bagdany, Miklos, Mulvihill, Cory M., Du, Kai, di Bernardo, Salvatore, Liu, Yuhong, Konermann, Lars, Roldan, Ariel, Lukacs, Gergely L.

“…The folding and misfolding mechanism of multidomain proteins remains poorly understood. Although thermodynamic instability of the first nucleotide-binding…”
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Quantitative Determination of Protein–Ligand Affinity by Size Exclusion Chromatography Directly Coupled to High-Resolution Native Mass Spectrometry by Ren, Chengfeng, Bailey, Aaron O, VanderPorten, Erica, Oh, Angela, Phung, Wilson, Mulvihill, Melinda M, Harris, Seth F, Liu, Yichin, Han, Guanghui, Sandoval, Wendy

“…High throughput protein–ligand interaction screening assays employing mass spectrometric detection are widely used in early stage drug discovery. Mass…”
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A mechanistic study identifying improved technology critical metal delamination from printed circuit boards at lower power sonications in a deep eutectic solvent by Jacobson, Ben, Li, Shida, Marin Rivera, Rodolfo, Daly, Paul, Elgar, Christopher E, Mulvihill, Daniel M, Abbott, Andrew P, Feeney, Andrew, Prentice, Paul

“…Deep eutectic solvents (DESs) are an emerging class of ionic liquids that offer a solution to reclaiming technology critical metals (TCMs) from electronic…”
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Improving thermal stability of hydrolysed whey protein-based infant formula emulsions by protein–carbohydrate conjugation by Drapala, Kamil P., Auty, Mark A.E., Mulvihill, Daniel M., O'Mahony, James A.

“…Whey protein hydrolysate (WPH) ingredients are commonly used in the manufacture of partially-hydrolysed infant formulae. The heat stability of these…”
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Ski regulates Hippo and TAZ signaling to suppress breast cancer progression by Rashidian, Juliet, Le Scolan, Erwan, Ji, Xiaodan, Zhu, Qingwei, Mulvihill, Melinda M, Nomura, Daniel, Luo, Kunxin

“…Ski, the transforming protein of the avian Sloan-Kettering retrovirus, inhibits transforming growth factor-β (TGF-β)/Smad signaling and displays both…”
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Organophosphorus Flame Retardants Inhibit Specific Liver Carboxylesterases and Cause Serum Hypertriglyceridemia by Morris, Patrick J, Medina-Cleghorn, Daniel, Heslin, Ann, King, Sarah M, Orr, Joseph, Mulvihill, Melinda M, Krauss, Ronald M, Nomura, Daniel K

“…Humans are prevalently exposed to organophosphorus flame retardants (OPFRs) contained in consumer products and electronics, though their toxicological effects…”
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N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic by Glozman, Rina, Okiyoneda, Tsukasa, Mulvihill, Cory M, Rini, James M, Barriere, Herve, Lukacs, Gergely L

“…N-glycosylation, a common cotranslational modification, is thought to be critical for plasma membrane expression of glycoproteins by enhancing protein folding,…”
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Opportunities and Challenges in Triboelectric Nanogenerator (TENG) based Sustainable Energy Generation Technologies: A Mini-Review by Walden, Ryan, Kumar, Charchit, Mulvihill, Daniel M., Pillai, Suresh C.

“…•The key advantages of TENGs are low cost and high efficiency at low frequencies.•The electrical output of TENGS remains low compared to other sustainable…”
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Controlled glycation of milk proteins and peptides: Functional properties by O'Mahony, James A., Drapala, Kamil P., Mulcahy, Eve M., Mulvihill, Daniel M.

“…Glycation of milk proteins and peptides can be achieved by Maillard-induced conjugation of reducing carbohydrates with the available amino groups of…”
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Sustainable ultra‐strong thermally conductive wood‐based antibacterial structural materials with anti‐corrosion and ultraviolet shielding by Ye, Haoran, Shi, Yang, Xu, Ben Bin, Guo, Zhanhu, Fan, Wei, Zhang, Zhongfeng, Mulvihill, Daniel M., Zhang, Xuehua, Shi, Pengju, He, Ximin, Ge, Shengbo

“…In light of the uprising global development on sustainability, an innovative and environmental friendly wood‐based material derived from natural pinewood has…”
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Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer by Kohnz, Rebecca A, Mulvihill, Melinda M, Chang, Jae Won, Hsu, Ku-Lung, Sorrentino, Antonio, Cravatt, Benjamin F, Bandyopadhyay, Sourav, Goga, Andrei, Nomura, Daniel K

“…Targeting dysregulated metabolic pathways is a promising therapeutic strategy for eradicating cancer. Understanding how frequently altered oncogenes regulate…”
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Teaching Qualitative Research: Strategies for Engaging Emerging Scholars by Swaminathan, Raji, Mulvihill, Thalia M

“…This timely resource provides a framework for teaching students how to think qualitatively and become more critical and reflexive researchers. Presented are a…”
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An elastic–plastic asperity interaction model for sliding friction by Mulvihill, D.M., Kartal, M.E., Nowell, D., Hills, D.A.

“…A finite-element model of the interaction of an elastic–plastic asperity junction based on cylindrical or spherical asperities is used to predict sliding…”
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Fetal and Neonatal Effects of N-Acetylcysteine When Used for Neuroprotection in Maternal Chorioamnionitis by Jenkins, Dorothea D., MD, Wiest, Donald B., PharmD, Mulvihill, Denise M., MD, Hlavacek, Anthony M., MD, Majstoravich, Sarah J., MD, Brown, Truman R., PhD, Taylor, Joseph J., PhD, Buckley, Jason R., MD, Turner, Robert P., MD, Rollins, Laura Grace, MS, Bentzley, Jessica P., BA, Hope, Kathryn E., MPH, Barbour, Andrew B., PhD, Lowe, Danielle W., BS, Martin, Renee H., PhD, Chang, Eugene Y., MD

“…Objective To evaluate the clinical safety of antenatal and postnatal N-acetylcysteine (NAC) as a neuroprotective agent in maternal chorioamnionitis in a…”
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Sensitivity of material failure to surface roughness: A study on titanium alloys Ti64 and Ti407 by Sneddon, Scott, Xu, Yang, Dixon, Mark, Rugg, David, Li, Peifeng, Mulvihill, Daniel M.

“…The relationship between material failure and surface roughness has been investigated using two titanium alloys: Ti64 and the more ductile Ti407. Three surface…”
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