Search Results - "Mulvey, Bernard"

Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays by Mulvey, Bernard, Dougherty, Joseph D.

“…Family and population studies indicate clear heritability of major depressive disorder (MDD), though its underlying biology remains unclear. The majority of…”
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Molecular and Functional Sex Differences of Noradrenergic Neurons in the Mouse Locus Coeruleus by Mulvey, Bernard, Bhatti, Dionnet L., Gyawali, Sandeep, Lake, Allison M., Kriaucionis, Skirmantas, Ford, Christopher P., Bruchas, Michael R., Heintz, Nathaniel, Dougherty, Joseph D.

“…Preclinical work has long focused on male animals, though biological sex clearly influences risk for certain diseases, including many psychiatric disorders…”
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Relationship between sex biases in gene expression and sex biases in autism and Alzheimer's disease by Fass, Stuart B, Mulvey, Bernard, Chase, Rebecca, Yang, Wei, Selmanovic, Din, Chaturvedi, Sneha M, Tycksen, Eric, Weiss, Lauren A, Dougherty, Joseph D

“…Sex differences in the brain may play an important role in sex-differential prevalence of neuropsychiatric conditions. In order to understand the…”
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Distinct behavioral phenotypes in novel “fast” kindling-susceptible and “slow” kindling-resistant rat strains selected by stimulation of the hippocampal perforant path by Langberg, Tomer, Dashek, Ryan, Mulvey, Bernard, Miller, Kimberly A, Osting, Susan, Stafstrom, Carl E, Sutula, Thomas P

“…Abstract Kindling is a phenomenon of activity-dependent neural circuit plasticity induced by repeated seizures that results in progressive permanent increases…”
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23. MASSIVELY PARALLEL, IN VIVO PROFILING OF MDD SNP EFFECTS ON TRANSCRIPTION ACROSS AGE, SEX, AND CELL TYPE by Mulvey, Bernard, Dougherty, Joseph

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Sex Significantly Impacts the Function of Major Depression–Linked Variants In Vivo by Mulvey, Bernard, Selmanovic, Din, Dougherty, Joseph D.

“…Genome-wide association studies have discovered blocks of common variants—likely transcriptional-regulatory—associated with major depressive disorder (MDD),…”
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Massively Parallel Reporter Assays: Defining Functional Psychiatric Genetic Variants Across Biological Contexts by Mulvey, Bernard, Lagunas, Tomás, Dougherty, Joseph D.

“…Neuropsychiatric phenotypes have long been known to be influenced by heritable risk factors, directly confirmed by the past decade of genetic studies that have…”
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15 TOWARD AN IN VIVO METHOD FOR CELL-TYPE SPECIFIC, MULTIPLEX ASSAYS OF NEUROPSYCHIATRIC-TRAIT ASSOCIATED TRANSCRIPTIONAL ELEMENTS by Mulvey, Bernard, Cohen, Barak, Dougherty, Joseph

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Weaving New Insights for the Genetic Regulation of Human Cognitive Phenotypes by Mulvey, Bernard, Dougherty, Joseph D.

“…Psychiatric genetic studies have drawn associations between human cognitive traits and noncoding genomic variants. However, the mechanistic effects of these…”
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T29. SPATIAL-MOLECULAR SEX DIFFERENCES IN THE HUMAN VENTROMEDIAL AND ARCUATE HYPOTHALAMUS by Mulvey, Bernard, Wang, Yi, Divecha, Heena R., Bach, Svitlana, Montgomery, Kelsey D., Cinquemani, Sophia, Du, Yufeng, Miller, Ryan, Kleinman, Joel E., Page, Stephanie Cerceo, Hyde, Thomas M., Hicks, Stephanie C., Hansen, Kasper D., Martinowich, Keri, Maynard, Kristen R.

“…The hypothalamus (HYP) coordinates core physiology and behaviors, such as growth, mating, parenting, aggression, appetite, and metabolism. Given these roles,…”
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Genetic and Transcriptomic Aspects of Major Depressive Disorder: In Vivo Functional Assays of Risk-Associated Variation, Candidate Disease Cell Types, and Their Pharmacologic and Sex Interactions by Mulvey, Bernard John

“…Major depressive disorder (MDD) is a debilitating illness that affects hundreds of millions globally, with substantial personal, medical, economic, and…”
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Extended amygdala-parabrachial circuits alter threat assessment and regulate feeding by Luskin, Andrew T, Bhatti, Dionnet L, Mulvey, Bernard, Pedersen, Christian E, Girven, Kasey S, Oden-Brunson, Hannah, Kimbell, Kate, Blackburn, Taylor, Sawyer, Abbie, Gereau, 4th, Robert W, Dougherty, Joseph D, Bruchas, Michael R

“…An animal's evolutionary success depends on the ability to seek and consume foods while avoiding environmental threats. However, how evolutionarily conserved…”
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The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease by Iannitelli, Alexa F, Kelberman, Michael A, Lustberg, Daniel J, Korukonda, Anu, McCann, Katharine E, Mulvey, Bernard, Segal, Arielle, Liles, L Cameron, Sloan, Steven A, Dougherty, Joseph D, Weinshenker, David

“…The noradrenergic locus coeruleus (LC) is among the earliest sites of tau and α-synuclein pathology in Alzheimer's disease (AD) and Parkinson's disease (PD),…”
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Cnih3 Deletion Dysregulates Dorsal Hippocampal Transcription across the Estrous Cycle by Mulvey, Bernard, Frye, Hannah E, Lintz, Tania, Fass, Stuart, Tycksen, Eric, Nelson, Elliot C, Morón, Jose A, Dougherty, Joseph D

“…In females, the hippocampus, a critical brain region for coordination of learning, memory, and behavior, displays altered physiology and behavioral output…”
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Digging for Gold: Irish Builders in Post-War London - Historical Representations and Realities by Mulvey, Michael Bernard

“…This thesis explores the lived experiences of Irish male migrants who came to London during and after World War Two to work as builders in the construction and…”
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The Cohn Rule - Its Present Day Impact by Mulvey, Bernard M

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NORMATIVE VALUES IN ERNEST HEMINGWAY'S FICTION by MULVEY, JAMES BERNARD

“…Hemingway's corpus, usually subtle in technique and theme, reaffirms the Christian world view of its author, whose religious awareness encircles almost the…”
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