Search Results - "Multhaupt, Hinke A B"

Syndecans – key regulators of cell signaling and biological functions by Afratis, Nikolaos A., Nikitovic, Dragana, Multhaupt, Hinke A. B., Theocharis, Achilleas D., Couchman, John R., Karamanos, Nikos K.

“…Syndecans are a small family of four transmembrane proteoglycans in mammals. They have similar structural organization, consisting of an N‐terminal ectodomain,…”
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Mapping of matrix metalloproteinase cleavage sites on syndecan‐1 and syndecan‐4 ectodomains by Manon‐Jensen, Tina, Multhaupt, Hinke A. B., Couchman, John R.

“…Syndecans are transmembrane heparan sulfate proteoglycans with roles in cell proliferation, differentiation, adhesion, and migration. They have been associated…”
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An Epidermal MicroRNA Regulates Neuronal Migration Through Control of the Cellular Glycosylation State by Pedersen, Mikael Egebjerg, Snieckute, Goda, Kagias, Konstantinos, Nehammer, Camilla, Multhaupt, Hinke A. B., Couchman, John R., Pocock, Roger

“…An appropriate balance in glycosylation of proteoglycans is crucial for their ability to regulate animal development. Here, we report that the Caenorhabditis…”
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Rho kinases I and II regulate different aspects of myosin II activity by Yoneda, Atsuko, Multhaupt, Hinke A.B, Couchman, John R

“…The homologous mammalian rho kinases (ROCK I and II) are assumed to be functionally redundant, based largely on kinase construct overexpression. As downstream…”
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Cell-extracellular matrix and cell-cell adhesion are linked by syndecan-4 by Gopal, Sandeep, Multhaupt, Hinke A.B., Pocock, Roger, Couchman, John R.

“…Cell-extracellular matrix (ECM) and cell-cell junctions that employ microfilaments are sites of tension. They are important for tissue repair, morphogenetic…”
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Cell surface heparan sulfate proteoglycans control adhesion and invasion of breast carcinoma cells by Lim, Hooi Ching, Multhaupt, Hinke A B, Couchman, John R

“…Cell surface proteoglycans interact with numerous regulators of cell behavior through their glycosaminoglycan chains. The syndecan family of transmembrane…”
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Syndecan-1 and Syndecan-4 Are Independent Indicators in Breast Carcinoma by Lendorf, Maria E., Manon-Jensen, Tina, Kronqvist, Pauliina, Multhaupt, Hinke A. B., Couchman, John R.

“…Syndecan proteoglycans may be key regulators of tumor invasion and metastasis because this four-member family of transmembrane receptors regulates cell…”
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Transmembrane proteoglycans control stretch-activated channels to set cytosolic calcium levels by Gopal, Sandeep, Søgaard, Pernille, Multhaupt, Hinke A B, Pataki, Csilla, Okina, Elena, Xian, Xiaojie, Pedersen, Mikael E, Stevens, Troy, Griesbeck, Oliver, Park, Pyong Woo, Pocock, Roger, Couchman, John R

“…Transmembrane heparan sulfate proteoglycans regulate multiple aspects of cell behavior, but the molecular basis of their signaling is unresolved. The major…”
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Extracellular matrix component signaling in cancer by Multhaupt, Hinke A.B., Leitinger, Birgit, Gullberg, Donald, Couchman, John R.

“…Cell responses to the extracellular matrix depend on specific signaling events. These are important from early development, through differentiation and tissue…”
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Two Transient Receptor Potential Channels at Focal Adhesions by Mitsou, Ioli, Carlson, Cathrine Rein, Multhaupt, Hinke A.B., Brakebusch, Cord, Couchman, John R.

“…Recently there have been reports that identify two transient receptor potential channels in cell–matrix junctions known as focal adhesions. These are the…”
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Minireview: Syndecans and their crucial roles during tissue regeneration by Chung, Heesung, Multhaupt, Hinke A. B., Oh, Eok‐Soo, Couchman, John R.

“…Syndecans are transmembrane heparan sulfate proteoglycans, with roles in development, tumorigenesis and inflammation, and growing evidence for involvement in…”
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Proteoglycans, ion channels and cell-matrix adhesion by Mitsou, Ioli, Multhaupt, Hinke A B, Couchman, John R

“…Cell surface proteoglycans comprise a transmembrane or membrane-associated core protein to which one or more glycosaminoglycan chains are covalently attached…”
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Insights into the key roles of proteoglycans in breast cancer biology and translational medicine by Theocharis, Achilleas D., Skandalis, Spyros S., Neill, Thomas, Multhaupt, Hinke A.B., Hubo, Mario, Frey, Helena, Gopal, Sandeep, Gomes, Angélica, Afratis, Nikos, Lim, Hooi Ching, Couchman, John R., Filmus, Jorge, Sanderson, Ralph D., Schaefer, Liliana, Iozzo, Renato V., Karamanos, Nikos K.

“…Proteoglycans control numerous normal and pathological processes, among which are morphogenesis, tissue repair, inflammation, vascularization and cancer…”
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Breast and Ovarian Cancers: A Survey and Possible Roles for the Cell Surface Heparan Sulfate Proteoglycans by Yoneda, Atsuko, Lendorf, Maria E., Couchman, John R., Multhaupt, Hinke A. B.

“…Tumor markers are widely used in pathology not only for diagnostic purposes but also to assess the prognosis and to predict the treatment of the tumor. Because…”
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Syndecans in wound healing, inflammation and vascular biology by Alexopoulou, Annika N., Multhaupt, Hinke A.B., Couchman, John R.

“…Syndecans are heparan sulphate proteoglycans consisting of a type I transmembrane core protein modified by heparan sulphate and sometimes chondroitin sulphate…”
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Protein Kinase C, Focal Adhesions and the Regulation of Cell Migration by Fogh, Betina S., Multhaupt, Hinke A.B., Couchman, John R.

“…Cell adhesion to extracellular matrix is a complex process involving protrusive activity driven by the actin cytoskeleton, engagement of specific receptors,…”
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Heparan Sulfate Biosynthesis: Methods for Investigation of the Heparanosome by Multhaupt, Hinke A. B., Couchman, John R.

“…Heparan sulfate is perhaps the most complex polysaccharide known from animals. The basic repeating disaccharide is extensively modified by sulfation and uronic…”
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Keratinocytes negatively regulate the N-cadherin levels of melanoma cells via contact-mediated calcium regulation by Chung, Heesung, Jung, Hyejung, Jho, Eek-hoon, Multhaupt, Hinke A.B., Couchman, John R., Oh, Eok-Soo

“…In human skin, melanocytes and their neighboring keratinocytes have a close functional interrelationship. Keratinocytes, which represent the prevalent cell…”
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Syndecans: from peripheral coreceptors to mainstream regulators of cell behaviour by Couchman, John R, Gopal, Sandeep, Lim, Hooi Ching, Nørgaard, Steffen, Multhaupt, Hinke AB

“…In the 25 years, as the first of the syndecan family was cloned, interest in these transmembrane proteoglycans has steadily increased. While four distinct…”
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Heparan Sulfate Chain Valency Controls Syndecan-4 Function in Cell Adhesion by Gopal, Sandeep, Bober, Adam, Whiteford, James R., Multhaupt, Hinke A.B., Yoneda, Atsuko, Couchman, John R.

“…Fibroblasts null for the transmembrane proteoglycan, syndecan-4, have an altered actin cytoskeleton, compared with matching wild-type cells. They do not…”
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