Search Results - "Multani, A S"

Linking genomic reorganization to tumor initiation via the giant cell cycle by Niu, N, Zhang, J, Zhang, N, Mercado-Uribe, I, Tao, F, Han, Z, Pathak, S, Multani, A S, Kuang, J, Yao, J, Bast, R C, Sood, A K, Hung, M-C, Liu, J

“…To investigate the mechanisms underlying our recent paradoxical finding that mitotically incapacitated and genomically unstable polyploid giant cancer cells…”
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Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis by Akbay, E A, Peña, C G, Ruder, D, Michel, J A, Nakada, Y, Pathak, S, Multani, A S, Chang, S, Castrillon, D H

“…Type II endometrial cancer (EMCA) represents only 10% of all EMCAs, but accounts for 40% of EMCA-related mortality. Previous studies of human tumors have shown…”
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Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis, resulting in B-cell lymphoma by Riley, M F, You, M J, Multani, A S, Lozano, G

“…Many human tumors express high levels of the p53 inhibitor Mdm2, resulting from amplification of the Mdm2 locus or aberrant post-translational regulation of…”
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Adenosine acts as an inhibitor of lymphoma cell growth: a major role for the A3 adenosine receptor by Fishman, P., Bar-Yehuda, S., Ohana, G., Pathak, S., Wasserman, L., Barer, F., Multani, A.S.

“…In this study, we demonstrated several mechanisms exploring the inhibitory effect of low-dose adenosine on lymphoma cell growth. Adenosine, a purine nucleoside…”
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Spontaneous regression of cutaneous melanoma in sinclair swine is associated with defective telomerase activity and extensive telomere erosion by Pathak, S, Multani, A S, McConkey, D J, Imam, A S, Amoss, Jr, M S

“…Recently we proposed the hypothesis that extensive telomeric association of chromosomes is an early manifestation of cell death and asked whether there are…”
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A comparative study of efficacy and safety of azithromycin and ofloxacin in uncomplicated typhoid Fever: a randomised, open labelled study by Chandey, Manish, Multani, A S

“…To compare the efficacy and safety of azithromycin with ofloxacin in patients with uncomplicated typhoid fever. Forty adult patients with bacteriologically or…”
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Can cancer cells transform normal host cells into malignant cells? by PATHAK, S, NEMETH, M. A, MULTANI, A. S, THALMANN, G. N, VON ESCHENBACH, A. C, CHUNG, L. W. K

“…A human prostate tumour cell line, LNCaP C4-2, when injected into athymic male nude mice, produced tumours containing: (1) only human cancer cells similar to…”
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DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: role of telomere repeat binding factor 2 by NARAYAN, S, JAISWAL, A. S, MULTANI, A. S, PATHAK, S

“…Treatment of colon cancer cells with MNNG causes DNA damage with reduced telomeric signals in a p53-dependent manner, but increased cell cycle arrest in…”
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Low-level c-myc amplification in human colonic carcinoma cell lines and tumors : A frequent, p53-independent mutation associated with improved outcome in a randomized multi-institutional trial by AUGENLICHT, L. H, WADLER, S, CORNER, G, RICHARDS, C, RYAN, L, MULTANI, A. S, PATHAK, S, BENSON, A, HALLER, D, HEERDT, B. G

“…Human colonic cancer is associated with multiple genetic deletions, mutations, and alterations in gene expression; in contrast, gene amplification has not been…”
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Reduction of telomeric signals in murine melanoma and human breast cancer cell lines treated with 3'-azido-2'-3'-dideoxythymidine by Multani, A S, Furlong, C, Pathak, S

“…The purpose of this study was to determine, using fluorescence in situ hybridization (FISH), whether treatment of cancer cells with…”
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Induction of apoptosis by the N-acetyl-galactosamine-specific toxic lectin from Viscum album L. is associated with a decrease of nuclear p53 and Bcl-2 proteins and induction of telomeric associations by Büssing, Arndt, Multani, Asha S, Pathak, Sen, Pfüller, Uwe, Schietzel, M

“…The ribosome-inhibiting proteins from Viscum album L., i.e. the mistletoe lectins (ML), were recognized to induce apoptosis in various tumour cell lines and…”
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Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA by Shou, Jiang, Ali-Osman, F, Multani, A S, Pathak, S, Fedi, P, Srivenugopal, K S

“…The human Dkk-1 (hDkk-1) gene, a transcriptional target of the p53 tumor suppressor, encodes a powerful inhibitor of the Wnt signaling pathway and regulates…”
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Heterochromatin and interstitial telomeric DNA homology by Multani, A S, Ozen, M, Furlong, C L, Zhao, Y J, Hsu, T C, Pathak, S

“…The purpose of this investigation was twofold. The first objective was to demonstrate that, in most of ten mammalian species commonly used in biomedical…”
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Amplification of telomeric DNA directly correlates with metastatic potential of human and murine cancers of various histological origin by Multani, A S, Ozen, M, Sen, S, Mandal, A K, Price, J E, Fan, D, Radinsky, R, Ali-Osman, F, Von Eschenbach, A C, Fidler, I J, Pathak, S

“…Telomeres, repeated DNA sequences (T2AG3)n that guard the ends of chromosomes, serve as a checkpoint for cell-cycle progression and regulate cell senescence…”
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Human tumor xenografts in nude mice are not always of human origin: a warning signal by Pathak, S, Nemeth, M A, Multani, A S

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MRI findings in methanol intoxication: a report of two cases by Arora, V, Nijjar, I B S, Multani, A S, Singh, J P, Abrol, R, Chopra, R, Attri, R

“…Methanol is a highly toxic substance and acute methanol poisoning produces severe metabolic acidosis and serious neurological symptoms, including severe visual…”
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Reduced telomeric signals and increased telomeric associations in human lung cancer cell lines undergoing p53-mediated apoptosis by MUKHOPADHYAY, T, MULTANI, A. S, ROTH, J. A, PATHAK, S

“…Transduction of a p53-negative H1299 human non-small cell lung cancer cell line with an adenoviral vector containing wild-type p53 (Ad5p53) induced apoptosis…”
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Paclitaxel and water-soluble poly (L-glutamic acid)-paclitaxel, induce direct chromosomal abnormalities and cell death in a murine metastatic melanoma cell line by Multani, A S, Li, C, Ozen, M, Yadav, M, Yu, D F, Wallace, S, Pathak, S

“…The purpose of this study was to demonstrate the effects of paclitaxel and water-soluble poly (L-glutamic acid)-paclitaxel (PG-TXL), on chromosome morphology,…”
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The A3 Adenosine Receptor as a New Target for Cancer Therapy and Chemoprotection by Fishman, Pnina, Bar-Yehuda, Sara, Barer, Faina, Madi, Lea, Multani, Asha S., Pathak, Sen

“…Adenosine, a purine nucleoside, acts as a regulatory molecule, by binding to specific G-protein-coupled A1, A2A, A2B, and A3 cell surface receptors. We have…”
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Conventional cytogenetics alone is not sufficient for identifying interspecies cell line contamination by Multani, A S, Pathak, S

“…Evidence from our laboratory suggests that conventional chromosome banding analysis alone is not sufficient for detecting interspecies contamination of cell…”
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