Effects of carprofen, meloxicam and deracoxib on platelet function in dogs

To determine effects of anti-inflammatory doses of COX-2 selective NSAIDs carprofen, meloxicam, and deracoxib on platelet function in dogs and urine 11-dehydro-thromboxane B2. Randomized, blocked, crossover design with a 14-day washout period. Healthy intact female Walker Hounds aged 1-6 years and w...

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Bibliographic Details
Published in:	Veterinary anaesthesia and analgesia Vol. 39; no. 2; p. 206
Main Authors:	Mullins, Kathleen B, Thomason, John M, Lunsford, Kari V, Pinchuk, Lesya M, Langston, Vernon C, Wills, Robert W, McLaughlin, Ronald M, Mackin, Andrew J
Format:	Journal Article
Language:	English
Published:	United States 01-03-2012
Subjects:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Blood Platelets - drug effects Carbazoles - pharmacology Dogs Female Hemostasis - drug effects Platelet Aggregation - drug effects Sulfonamides - pharmacology Thiazines - pharmacology Thiazoles - pharmacology Thromboxane B2 - analogs & derivatives Thromboxane B2 - urine
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Summary:	To determine effects of anti-inflammatory doses of COX-2 selective NSAIDs carprofen, meloxicam, and deracoxib on platelet function in dogs and urine 11-dehydro-thromboxane B2. Randomized, blocked, crossover design with a 14-day washout period. Healthy intact female Walker Hounds aged 1-6 years and weighing 20.5-24.2 kg. Dogs were given NSAIDs for 7 days at recommended doses: carprofen (2.2 mg kg(-1), PO, every 12 hours), carprofen (4.4 mg kg(-1), PO, every 24 hours), meloxicam (0.2 mg kg(-1), PO, on the 1st day then 0.1 mg kg(-1), PO, every 24 hours), and deracoxib (2 mg kg(-1), PO, every 24 hours). Collagen/epinephrine and collagen/ADP PFA-100 cartridges were used to evaluate platelet function before and during and every other day after administration of each drug. Urine 11-dehydro-thromboxane B(2) was also measured before and during administration of each drug. All NSAIDs significantly prolonged PFA-100 closure times when measured with collagen/epinephrine cartridges, but not with collagen/ADP cartridges. The average duration from drug cessation until return of closure times (collagen/epinephrine cartridges) to baseline values was 11.6, 10.6, 11 and 10.6 days for carprofen (2.2 mg kg(-1) every 12 hours), carprofen (4.4 mg kg(-1) every 24 hours), meloxicam and deracoxib, respectively. Oral administration of some COX-2 selective NSAIDs causes detectable alterations in platelet function in dogs. As in humans, PFA-100 collagen/ADP cartridges do not reliably detect COX-mediated platelet dysfunction in dogs. Individual assessment of platelet function is advised when administering these drugs prior to surgery, particularly in the presence of other risk factors for bleeding.
ISSN:	1467-2995
DOI:	10.1111/j.1467-2995.2011.00684.x